Predictor
|
Odds-Ratio (95% CI)
|
p-value
|
Age (years)
|
0.53 (0.19, 1.47)
|
p=0.221
|
Body Mass Index (kg/m2)
|
1.19 (0.38, 3.73)
|
p=0.761
|
log NT-proBNP (pg/mL)
|
1.06 (0.36, 3.12)
|
p=0.910
|
Glomerular Filtration Rate (mL/min)
|
0.18 (0.05, 0.66)
|
p=0.010*
|
Hemoglobin (g/dL)
|
0.51 (0.15, 1.81)
|
p=0.300
|
International Normalized Ratio
|
2.77 (1.28, 6.00)
|
p=0.010*
|
Platelets
|
0.79 (0.24, 2.66)
|
p=0.707
|
Creatinine (mg/dL)
|
3.71 (1.63, 8.46)
|
p=0.002*
|
C-Reactive Protein
|
2.49 (1.09, 5.72)
|
p=0.031*
|
Prealbumin (mg/L)
|
0.21 (0.05, 0.85)
|
p=0.029*
|
Sodium
|
1.33 (0.41, 4.30)
|
p=0.638
|
Albumin(mg/dL)
|
0.22 (0.07, 0.69)
|
p=0.010*
|
ALT
|
1.80 (1.02, 3.17)
|
p=0.041*
|
AST
|
2.08 (0.94, 4.58)
|
p=0.070
|
Total Bilirubin (mg/d)
|
1.93 (1.03, 3.59)
|
p=0.039*
|
Total Cholesterol (mg/dL)
|
3.46 (1.27, 9.40)
|
p=0.015*
|
High Density Lipoprotein (mg/dL)
|
1.01 (0.32, 3.23)
|
p=0.981
|
White Blood Cell Count
|
2.31 (1.01, 5.28)
|
p=0.047*
|
Partial thromboplastin time
|
1.65 (0.73, 3.75)
|
p=0.228
|
log NT-proBNP (pg/mL)
|
1.06 (0.36, 3.12)
|
p=0.910
|
Heart Rate (beats/min)
|
1.22 (0.39, 3.82)
|
p=0.736
|
Diastolic Blood Pressure (mmHg)
|
0.73 (0.25, 2.19)
|
p=0.578
|
Ejection Fraction (percent)
|
2.10 (0.74, 5.94)
|
p=0.161
|
Left ventricular End Diastolic Dimension (cm)
|
0.85 (0.27, 2.69)
|
p=0.776
|
Left ventricular End Systolic Dimension (cm)
|
0.62 (0.19, 1.97)
|
p=0.417
|
International normalized ratio
|
2.77 (1.28, 6.00)
|
p=0.010*
|
Mean Arterial Pressure (mmHg)
|
0.55 (0.20, 1.54)
|
p=0.256
|
Systolic Blood Pressure (mmHg)
|
0.51 (0.18, 1.47)
|
p=0.215
|
Cardiac Output (L/min)
|
1.34 (0.43, 4.13)
|
p=0.615
|
Right Atrial Pressure (mmHg)
|
1.04 (0.33, 3.31)
|
p=0.949
|
Pulmonary Artery Systolic Pressure (mmHg)
|
0.21 (0.06, 0.77)
|
p=0.019*
|
Pulmonary Capillary Wedge Pressure (mmHg)
|
0.40 (0.12, 1.34)
|
p=0.140
|
Pulmonary Artery Diastolic Pressure (mmHg)
|
0.48 (0.14, 1.63)
|
p=0.239
|
Pulmonary Pulse Pressure (mmHg)
|
0.22 (0.06, 0.76)
|
p=0.016*
|
Pulmonary Artery Elastance (mmHg/mL)
|
0.49 (0.12, 2.04)
|
p=0.327
|
Pulmonary Artery Compliance (mL∙mmHg-1)
|
1.66 (0.77, 3.55)
|
p=0.193
|
Pulmonary Artery Pulsatility Index
|
0.21 (0.02, 2.53)
|
p=0.218
|
Right atrial: Wedge Pressure Ratio
|
1.51 (0.56, 4.07)
|
p=0.415
|
Right Ventricular End Diastolic Pressure (mmHg)
|
1.76 (0.57, 5.48)
|
p=0.327
|
Systolic Blood Pressure (mmHg)
|
0.51 (0.18, 1.47)
|
p=0.215
|
Stroke Volume (mL)
|
1.10 (0.36, 3.31)
|
p=0.870
|
EUROMACS Score
|
6.88 (2.31, 20.45)
|
P=0.001
|
Legend: Each odds ratio estimate reflects a 2 standard deviation change in the corresponding variable.
Table2b: Odds-ratios of each binary risk factor for early right heart failure based on Univariate Logistic Regression Models
Predictor
|
Odds-Ratio (95% CI)
|
p-value
|
Sex
|
2.51 (0.32, 19.96)
|
p=0.384
|
Bridge to Transplant LVAD
|
0.68 (0.21, 2.2)
|
p=0.520
|
Diabetes Mellitus
|
0.51 (0.15, 1.73)
|
p=0.280
|
Non-Ischemic Cardiomyopathy Type
|
0.28 (0.07, 1.07)
|
p=0.063
|
Coronary Artery Disease
|
0.39 (0.12, 1.29)
|
p=0.123
|
Atrial Fibrillation
|
0.83 (0.26, 2.68)
|
p=0.755
|
History of Coronary Artery Bypass Surgery
|
0.77 (0.16, 3.62)
|
p=0.739
|
Chronic Obstructive Pulmonary Disease
|
0.62 (0.13, 2.91)
|
p=0.545
|
Hypercholesterolemia
|
1.14 (0.36, 3.64)
|
p=0.823
|
Hypertension
|
0.85 (0.27, 2.7)
|
p=0.779
|
Implanted Cardiac Defibrillator
|
0.55 (0.16, 1.89)
|
p=0.340
|
History of Smoking
|
0.85 (0.18, 4.02)
|
p=0.840
|
Ventilator Use
|
4.34 (1.22, 15.45)
|
p=0.023*
|
Continuous renal replacement therapy
|
0 (0, Inf)
|
p=0.992
|
Inotropes
|
2.76 (0.73, 10.45)
|
p=0.135
|
Multiple Inotropes
|
10.52 (3.12, 35.53)
|
p<0.001*
|
Extra corporal membrane oxygenation
|
5.87 (1.42, 24.32)
|
p=0.015*
|
Impella
|
10.91 (0.92, 129.67)
|
p=0.058
|
Intra-aortic balloon pump (Non-Elective)
|
3.25 (1.01, 10.46)
|
p=0.049*
|
Table 2c: Likelihood ratio test p-value corresponding to each categorical risk factor for early right heart based on univariate logistic regression models. (Omitting odd-ratios as there are multiple per variable)
|
Predictor
|
Odds-Ratio (95% CI)
|
p-value
|
Race
|
--
|
p=0.523
|
INTERMACS Profile
|
--
|
p=0.142
|
Right Ventricle Function
|
--
|
p=0.307
|
Right Ventricle Size
|
--
|
p=0.890
|
Tricuspid Regurgitation Grade
|
--
|
p=0.293
|
Legend INTERMACS: Interagency Registry for Mechanical Circulatory Support
|