The results of the cyclopeptide self-assembly fluorescence curve showed that, on the one hand, the aromatic amino acid groups in the cyclopeptide molecules, namely tryptophan, tyrosine and phenylalanine, were in microenvironments with different concentrations. Due to the non-covalent weak force, the absorption peaks of different aromatic amino acid groups showed a bimodal pattern. This non-covalent weak force molecular simulation explained that the epidemic transmission curve might show a bimodal pattern. It has been reported that a bimodal pattern might occur with different time delays of epidemic transmission between the two layers, which further proved that the basic component was caused by weak coupling conditions between the layers 2. On the other hand, the concentration of cyclopeptide molecules and free diffusion dominated the fluorescence sequential curve, and the change of solvent polar environment determined the fluorescence synchronous curve. The fluorescence synchronous curve was the result of molecular transformation from free diffusion to molecular polymerization. The results showed that the regulation of cyclopeptide self-assembly was related to the change of molecular concentration and solvent polarity. Nanofibers and nanospheres could be assembled through hydrogen bonding, π-π stacking, hydrophobic interaction, van der Waals interaction, etc. When the solution environment changed rapidly, the hydrophobic interaction becomed very strong instantly, which led to the self-assembly behavior and rapid phase transition of cyclopeptide. Through the characteristics of cyclopeptide self-assembly behavior changes, the sequential and synchronous complex models of epidemics could be simulated. The intensity and wavelength of the cyclic peptide self-assembly fluorescence curve reflected the number of cases and time of epidemic curve. The change of solvent polarity environment did not significantly change the self-assembly of low-concentration cyclic peptides, and the self-assembly of fluorescence detection of low-concentration cyclic peptides showed a synchronization curve (S1 and S2), and the synchronization curve flattened significantly, reflecting that if the number of epidemic patients is not large, it is easier to control the epidemic growth synchronously and quickly, and flatten the curve. The formation of disordered nanospheres with high concentration of cyclopeptides was accompanied by rapid self-assembly, which was observed by electron microscopy to form nanosphere aggregates. Fluorescence detection showed that the sequential and synchronous curves were significantly different from the results of low concentration cyclopeptide, reflecting the complexity of the epidemic. However, in the cyclopeptide self-assembly, the low concentration synchronous curve was consistent with the high concentration synchronous curve. The results showed that regardless of the degree of outbreak, as long as the global synchronous action was taken, the epidemic would be controlled earlier. The experimental results here were consistent with the "whole society as one" and "whole government as one" as the most important measures4. Molecular simulations elucidated why the global pandemic required global solidarity and synchronization.