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Research Article
Akira Kodama
Hiroshima University
Corresponding Author
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Carbon Nanotubes (CNTs) are cylindrical nanostructures, and have unique combination of properties including flexibility, electrical conductivity, and biocompatibility. We focused on CNTs fabricated with the carbon nanotube yarns (cYarn®) as a possible substrate that could promote peripheral nerve regeneration with these properties. We bridged a 15mm rat sciatic nerve defect with five different density of cYarn®. Eight weeks after the surgery, the density of regenerated axons crossing the CNTs, electromyographical findings, and muscle weight ratio of the lower leg showed recovery of the motor function by the interfacing with cYarn®. Our results indicated that a 2% CNT density tended to be most effective for nerve regeneration as measured by both histological axonal regeneration and motor function. We confirmed that CNT yarn, used as a scaffold bridging nerve gaps, promotes peripheral nerve regeneration. Our results support the future clinical application of CNTs for bridging nerve gaps as an off-the-shelf material.
Keywords
Carbon Nanotubes, carbon nanotube yarns, axonal regeneration
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Competing interest reported. The authors (Takahiro Ueda, Marcio DE. Lima, Takeshi Kondo) employed by Lintec of America Inc., where cYarn is producted. Other authors don't have any competing interests / conflict of interests to declare.
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CURRENT STATUS: Under Revision
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Posted 04 Mar, 2021
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On 25 Mar, 2021
Review #4 received
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Reviewer #3 agreed
On 08 Mar, 2021
Reviewer #7 agreed
On 06 Mar, 2021
Reviewer #1 agreed
On 06 Mar, 2021
Reviewer #11 agreed
On 06 Mar, 2021
Reviewer #9 agreed
On 06 Mar, 2021
Reviewer #13 agreed
On 06 Mar, 2021
Reviewer #5 agreed
On 06 Mar, 2021
Reviewer #4 agreed
On 06 Mar, 2021
Reviewer #6 agreed
On 06 Mar, 2021
Reviewer #10 agreed
On 06 Mar, 2021
Reviewer #8 agreed
On 06 Mar, 2021
Reviewer #2 agreed
On 06 Mar, 2021
Reviewer #12 agreed
On 06 Mar, 2021
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Akira Kodama
Hiroshima University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 04 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 25 Mar, 2021
Review #4 received
Received 08 Mar, 2021
Review #2 received
Received 08 Mar, 2021
Review #6 received
Received 08 Mar, 2021
Review #3 received
Received 08 Mar, 2021
Review #1 received
Received 08 Mar, 2021
Review #5 received
Received 08 Mar, 2021
Reviewer #3 agreed
On 08 Mar, 2021
Reviewer #7 agreed
On 06 Mar, 2021
Reviewer #1 agreed
On 06 Mar, 2021
Reviewer #11 agreed
On 06 Mar, 2021
Reviewer #9 agreed
On 06 Mar, 2021
Reviewer #13 agreed
On 06 Mar, 2021
Reviewer #5 agreed
On 06 Mar, 2021
Reviewer #4 agreed
On 06 Mar, 2021
Reviewer #6 agreed
On 06 Mar, 2021
Reviewer #10 agreed
On 06 Mar, 2021
Reviewer #8 agreed
On 06 Mar, 2021
Reviewer #2 agreed
On 06 Mar, 2021
Reviewer #12 agreed
On 06 Mar, 2021
Reviewers invited
Invitations sent on 05 Mar, 2021
Editor assigned
On 25 Feb, 2021
Editor invited
On 25 Feb, 2021
Submission checks complete
On 25 Feb, 2021
First submitted
On 23 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Carbon Nanotubes (CNTs) are cylindrical nanostructures, and have unique combination of properties including flexibility, electrical conductivity, and biocompatibility. We focused on CNTs fabricated with the carbon nanotube yarns (cYarn®) as a possible substrate that could promote peripheral nerve regeneration with these properties. We bridged a 15mm rat sciatic nerve defect with five different density of cYarn®. Eight weeks after the surgery, the density of regenerated axons crossing the CNTs, electromyographical findings, and muscle weight ratio of the lower leg showed recovery of the motor function by the interfacing with cYarn®. Our results indicated that a 2% CNT density tended to be most effective for nerve regeneration as measured by both histological axonal regeneration and motor function. We confirmed that CNT yarn, used as a scaffold bridging nerve gaps, promotes peripheral nerve regeneration. Our results support the future clinical application of CNTs for bridging nerve gaps as an off-the-shelf material.
Figure 1
Figure 2
Figure 3
Figure 4
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