This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Xiao-Li Shen
second Hospital of Nanchang university
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9541-3462
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This work is licensed under a CC BY 4.0 License. Read Full License
Low-grade gliomas (LGGs) are slow-growing brain cancer in central nervous system neoplasms. EMILIN2 is an extracellular matrix (ECM) protein which could influence the progress of some tumour which is unclear in LGG. In our study, the methylation, expression, prognosis and immune value of EMILIN2 were analysed in LGG through bioinformatics analysis. we first analysed the LGG data from TCGA and discovered that the EMILIN2 expression, negatively correlated to the EMILIN2 methylation could predict a poor prognosis and associated with different clinical parameters. Moreover, univariate and multivariate Cox regression were performed in CGGA showed that the EMILIN2 could be an independent prognostic biomarker in LGG. Finally, EMILIN2 expression showed a correlation with gene makers in some immune cells which identified the significance of EMILIN2 in immune infiltration. In conclusion, EMILIN2 could act as an independent prognostic biomarker which might be associated with the malignancy and development of gliomas and play a crucial role in glioma in immune infiltration.
Keywords
EMILIN2, methylation, immune, prognostic biomarker, LGG
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research
Xiao-Li Shen
second Hospital of Nanchang university
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9541-3462
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 04 Mar, 2021
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Translational Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Low-grade gliomas (LGGs) are slow-growing brain cancer in central nervous system neoplasms. EMILIN2 is an extracellular matrix (ECM) protein which could influence the progress of some tumour which is unclear in LGG. In our study, the methylation, expression, prognosis and immune value of EMILIN2 were analysed in LGG through bioinformatics analysis. we first analysed the LGG data from TCGA and discovered that the EMILIN2 expression, negatively correlated to the EMILIN2 methylation could predict a poor prognosis and associated with different clinical parameters. Moreover, univariate and multivariate Cox regression were performed in CGGA showed that the EMILIN2 could be an independent prognostic biomarker in LGG. Finally, EMILIN2 expression showed a correlation with gene makers in some immune cells which identified the significance of EMILIN2 in immune infiltration. In conclusion, EMILIN2 could act as an independent prognostic biomarker which might be associated with the malignancy and development of gliomas and play a crucial role in glioma in immune infiltration.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5
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