Regional lymph node involvement is rare in patients with malignant bone tumors. We aimed to analyze the prevalence and prognostic implications in the lymph-involved patients with malignant bone tumors.
Materials and Methods
From 1988 to 2016, 9582 patients with primary malignant bone tumors in the SEER database were enrolled. Overall survival (OS) was computed using the Kaplan-Meier method. A multivariate analysis was performed using the Cox regression.
346 (3.63%) patients exhibited regional lymph node involvement. Lymph-involved patients had larger tumor size and more metastasis than patients without. Ewing sarcoma most frequently developed lymph node involvement. Lymph-involved patients (0.31 95% CI (0.26–0.37)) had lower 5-year OS rates than patients without lymph node involvement (0.66 95% CI (0.65–0.68)) (p<0.001).
Lymph node involvement is rare in patients with malignant bone tumors. They had a large tumor size, more distant metastasis and poor survival.