1 Mayol-Llinas, J., Nelson, A., Farnaby, W. & Ayscough, A. Assessing molecular scaffolds for CNS drug discovery. Drug Discov. Today 22, 965-969 (2017).
2 Stütz, A. Allylamine derivatives—a new class of active substances in antifungal chemotherapy. Angew. Chem. Int. Ed. 26, 320-328 (1987).
3 Petranyi, G., Ryder, N. & Stutz, A. Allylamine derivatives: new class of synthetic antifungal agents inhibiting fungal squalene epoxidase. Science 224, 1239-1241 (1984).
4 JA, B. & D, F. Terbinafine. a review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in superficial mycoses. Drugs. 43, 259-284 (1992).
5 World Health Organization Model List of Essential Medicines, 21st List, 2019. Geneva: World Health Organization; 2019.
6 Park, C.-M. et al. Discovery of an orally bioavailable small molecule inhibitor of prosurvival B-cell lymphoma 2 proteins. J. Med. Chem. 51, 6902-6915 (2008).
7 Roberts, A. W. et al. Targeting BCL2 with venetoclax in relapsed chronic lymphocytic leukemia. N. Engl. J. Med. 374, 311-322 (2015).
8 Johannsen, M. & Jørgensen, K. A. Allylic amination. Chem. Rev. 98, 1689-1708 (1998).
9 Bayeh, L., Le, P. Q. & Tambar, U. K. Catalytic allylic oxidation of internal alkenes to a multifunctional chiral building block. Nature 547, 196-200 (2017).
10 Teh, W. P., Obenschain, D. C., Black, B. M. & Michael, F. E. Catalytic metal-free allylic C-H amination of terpenoids. J. Am. Chem. Soc. 142, 16716-16722 (2020).
11 Liang, C. et al. Toward a synthetically useful stereoselective C-H amination of hydrocarbons. J. Am. Chem. Soc. 130, 343-350 (2008).
12 Harvey, M. E., Musaev, D. G. & Du Bois, J. A diruthenium catalyst for selective, intramolecular allylic C-H amination: reaction development and mechanistic insight gained through experiment and theory. J. Am. Chem. Soc. 133, 17207-17216 (2011).
13 Reed, S. A., Mazzotti, A. R. & White, M. C. A catalytic, Bronsted base strategy for intermolecular allylic C-H amination. J. Am. Chem. Soc. 131, 11701-11706 (2009).
14 Pattillo, C. C. et al. Aerobic linear allylic C-H amination: overcoming benzoquinone inhibition. J. Am. Chem. Soc. 138, 1265-1272 (2016).
15 Yin, G., Wu, Y. & Liu, G. Scope and mechanism of allylic C-H amination of terminal alkenes by the Palladium/PhI(OPiv)2 catalyst system: insights into the effect of naphthoquinone. J. Am. Chem. Soc. 132, 11978-11987 (2010).
16 Lei, H. & Rovis, T. A site-selective amination catalyst discriminates between nearly identical C-H bonds of unsymmetrical disubstituted alkenes. Nat. Chem. 12, 725-731 (2020).
17 Burman, J. S. & Blakey, S. B. Regioselective intermolecular allylic C-H amination of disubstituted olefins via Rhodium/π-allyl intermediates. Angew. Chem. Int. Ed. 56, 13666-13669 (2017).
18 Trowbridge, A., Walton, S. M. & Gaunt, M. J. New strategies for the transition-metal catalyzed synthesis of aliphatic amines. Chem. Rev. 120, 2613-2692 (2020).
19 Mao-Lin Li, J.-H. Y., Yi-Hao Li, Shou-Fei Zhu, Qi-Lin Zhou. Highly enantioselective carbene insertion into N–H bonds of aliphatic amines. Science 366, 990-994 (2019).
20 Ramirez, T. A., Zhao, B. & Shi, Y. Recent advances in transition metal-catalyzed sp3 C-H amination adjacent to double bonds and carbonyl groups. Chem. Soc. Rev. 41, 931-942 (2012).
21 Park, Y., Kim, Y. & Chang, S. Transition metal-catalyzed C–H amination: scope, mechanism, and applications. Chem. Rev. 117, 9247-9301 (2017).
22 Wang, H., Gao, X., Lv, Z., Abdelilah, T. & Lei, A. Recent advances in oxidative R(1)-H/R(2)-H cross-coupling with hydrogen evolution via photo-/electrochemistry. Chem. Rev. 119, 6769−6787 (2019).
23 Musacchio, A. J. et al. Catalytic intermolecular hydroaminations of unactivated olefins with secondary alkyl amines. Science 355, 727-730 (2017).
24 Ruffoni, A. et al. Practical and regioselective amination of arenes using alkyl amines. Nat. Chem. 11, 426-433 (2019).
25 Cheng, Q., Chen, J., Lin, S. & Ritter, T. Allylic amination of alkenes with iminothianthrenes to afford alkyl allylamines. J. Am. Chem. Soc. 142, 17287-17293 (2020).
26 Ganley, J. M., Murray, P. R. D. & Knowles, R. R. Photocatalytic generation of aminium radical cations for C-N Bond Formation. ACS Catal. 10, 11712-11738 (2020).
27 Li, J. et al. Site-specific allylic C-H bond functionalization with a copper-bound N-centred radical. Nature 574, 516-521 (2019).
28 Li, G., Han, A., Pulling, M. E., Estes, D. P. & Norton, J. R. Evidence for formation of a Co-H bond from (H2O)2Co(dmgBF2)2 under H2: application to radical cyclizations. J. Am. Chem. Soc. 134, 14662-14665 (2012).
29 Vitaku, E., Smith, D. T. & Njardarson, J. T. Analysis of the structural diversity, substitution patterns, and frequency of nitrogen heterocycles among U.S. FDA approved pharmaceuticals. J. Med. Chem. 57, 10257-10274 (2014).
30 Vasseur, A., Bruffaerts, J. & Marek, I. Remote functionalization through alkene isomerization. Nat .Chem. 8, 209-219 (2016).
31 Burcul, F., Blazevic, I., Radan, M. & Politeo, O. Terpenes, phenylpropanoids, sulfur and other essential oil constituents as inhibitors of cholinesterases. Curr. Med. Chem. 27, 4297-4343 (2020).