Background Recent scientific reports brought into light a new concept of goal-directed perfusion (GDP) that aims to recreate physiological conditions in which the risk of end-organ malperfusion is minimalized. The aim of our study was to analyse patient’s interim physiology while on cardiopulmonary bypass based on the haemodynamic and tissue oxygen delivery measurements. We also aimed to create a universal formula that may help in the further implementation of the GDP concept. Methods We retrospectively analysed patients operated at Wroclaw University Hospital between June 2017 and December 2018. Since our observations provided a huge amount of data, including the patient's demographics, surgery details, and the perfusion-related data, the Data Science methodology was applied. Results A total of 272 (mean age 62.5±12.4, 74% male) cardiac surgery patients were included in the study. To study the relationship between haemodynamic and tissue oxygen parameters, the data for three different values of DO2i (280 ml/min/m2, 330 ml/min/m2 and 380ml/min/m2), were evaluated. Each set of those lines showed a descending function of CI in Hb concentration for the set DO2i. Conclusions Modern calculation tools make it possible to create a common data platform from a very large database. Using that methodology, we created models of haemodynamic compounds describing tissue oxygen delivery. The obtained unique patterns may both allow the adaptation of the flow in relation to the patient’s unique morphology that changes in time and contributes to the wider and safer implementation of tailored to individual patient’s needs perfusion strategy.