Hemodilution is Associated with Underestimation of Serum Creatinine in Cardiac Surgery Patients: A retrospective analysis
Background: Fluid overload is related to the development and prognosis of cardiac surgery-associated acute kidney injury (CSA-AKI). The study is to investigate the influence of serum creatinine (SCr) corrected by fluid balance on the prognosis of patients with cardiac surgery.
Methods: A retrospective study was conducted in 1334 patients who underwent elective cardiac surgery from January 1 to December 31, 2015. Kidney Disease: Improving Global Outcomes (KDIGO) criteria for AKI were applied to identify CSA-AKI. SCr was measured every 24 hours during ICU period and was accordingly adjusted for cumulative fluid balance. Changes in SCr, defined as ∆Crea, were determined by difference between before and after adjustment for cumulative fluid balance. All patients were then divided into three groups: underestimation group (∆Crea ≥ P75), normal group (P25 < ∆Crea < P75) and overestimation group (∆Crea ≤ P25).
Results: The incidence of AKI increased from 29.5% to 31.8% after adjustment for fluid balance. Patients in underestimation group showed prolonged length of ICU stay compared with normal group and overestimation group (3.2[1.0-4.0] vs 2.1[1.0-3.0] d, P < 0.001; 3.2[1.0-4.0] vs 2.3[1.0-3.0] d, P < 0.001). Length of hospital stay and mechanical ventilation dependent days in underestimation group were significantly longer than normal group (P < 0.001). Multivariate analysis showed age, baseline SCr and left ventricular ejection fraction were independently associated with underestimation of creatinine.
Conclusions: Cumulative fluid balance after cardiac surgery disturbs accurate measurement of serum creatinine. Patients with underestimation of SCr were associated with poor prognosis.
Figure 1
Posted 31 Dec, 2020
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Received 28 Dec, 2020
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On 04 May, 2020
On 04 May, 2020
Hemodilution is Associated with Underestimation of Serum Creatinine in Cardiac Surgery Patients: A retrospective analysis
Posted 31 Dec, 2020
Invitations sent on 28 Dec, 2020
On 28 Dec, 2020
Received 28 Dec, 2020
On 15 Dec, 2020
On 15 Dec, 2020
On 15 Dec, 2020
On 06 Dec, 2020
Received 29 Nov, 2020
Received 26 Nov, 2020
On 09 Nov, 2020
Invitations sent on 09 Nov, 2020
On 09 Nov, 2020
On 12 Oct, 2020
On 11 Oct, 2020
On 11 Oct, 2020
On 27 Aug, 2020
Received 12 Aug, 2020
On 05 Aug, 2020
Received 17 Jun, 2020
On 02 Jun, 2020
Invitations sent on 31 May, 2020
On 05 May, 2020
On 04 May, 2020
On 04 May, 2020
On 04 May, 2020
Background: Fluid overload is related to the development and prognosis of cardiac surgery-associated acute kidney injury (CSA-AKI). The study is to investigate the influence of serum creatinine (SCr) corrected by fluid balance on the prognosis of patients with cardiac surgery.
Methods: A retrospective study was conducted in 1334 patients who underwent elective cardiac surgery from January 1 to December 31, 2015. Kidney Disease: Improving Global Outcomes (KDIGO) criteria for AKI were applied to identify CSA-AKI. SCr was measured every 24 hours during ICU period and was accordingly adjusted for cumulative fluid balance. Changes in SCr, defined as ∆Crea, were determined by difference between before and after adjustment for cumulative fluid balance. All patients were then divided into three groups: underestimation group (∆Crea ≥ P75), normal group (P25 < ∆Crea < P75) and overestimation group (∆Crea ≤ P25).
Results: The incidence of AKI increased from 29.5% to 31.8% after adjustment for fluid balance. Patients in underestimation group showed prolonged length of ICU stay compared with normal group and overestimation group (3.2[1.0-4.0] vs 2.1[1.0-3.0] d, P < 0.001; 3.2[1.0-4.0] vs 2.3[1.0-3.0] d, P < 0.001). Length of hospital stay and mechanical ventilation dependent days in underestimation group were significantly longer than normal group (P < 0.001). Multivariate analysis showed age, baseline SCr and left ventricular ejection fraction were independently associated with underestimation of creatinine.
Conclusions: Cumulative fluid balance after cardiac surgery disturbs accurate measurement of serum creatinine. Patients with underestimation of SCr were associated with poor prognosis.
Figure 1