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Research Article
Jin Seok Heo
Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
The latest guidelines from the Enhanced Recovery After Surgery (ERAS®) Society stated that early drain removal after pancreatoduodenectomy (PD) is beneficial in decreasing the complications including postoperative pancreatic fistulas (POPFs). This study aimed to ascertain the actual benefits of early drain removal after PD.
The data of 450 patients who underwent PD between 2018 and 2020 were retrospectively reviewed. The surgical outcomes were compared between patients whose drains were removed within postoperative 3 days (early removal group) and after 5 days (late removal group). Logistic regression analysis was performed to identify the risk factors for clinically relevant POPFs (CR-POPFs).
Among 338 patients with drain fluid amylase levels of less than 5000 IU on the first day after surgery, the early removal group (n=81) had fewer complications and shorter hospital stays than the late removal group (n=257) (30.9% vs 54.5%, p < 0.001; 9.8 days vs 12.5 days, p = 0.030, respectively). The incidence rates of specific complications including CR-POPFs were comparable between the two groups. Risk factor analysis showed that early drain removal did not increase the risk of CR-POPFs (p = 0.163).
Although early drain removal after PD has not been identified as apparently beneficial, this study showed that it may contribute to an early return to normal life without increasing complications.
Keywords
pancreatoduodenectomy, postoperative pancreatic fistula, surgical drain, perianastomotic drain, the Enhanced Recovery After Surgery
No competing interests reported.
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Jin Seok Heo
Division of Hepatobiliary-Pancreatic Surgery, Department of Surgery, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Mar, 2021
No community comments so far
Editor invited
On 05 Mar, 2021
Submission checks complete
On 04 Mar, 2021
First submitted
On 23 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
The latest guidelines from the Enhanced Recovery After Surgery (ERAS®) Society stated that early drain removal after pancreatoduodenectomy (PD) is beneficial in decreasing the complications including postoperative pancreatic fistulas (POPFs). This study aimed to ascertain the actual benefits of early drain removal after PD.
The data of 450 patients who underwent PD between 2018 and 2020 were retrospectively reviewed. The surgical outcomes were compared between patients whose drains were removed within postoperative 3 days (early removal group) and after 5 days (late removal group). Logistic regression analysis was performed to identify the risk factors for clinically relevant POPFs (CR-POPFs).
Among 338 patients with drain fluid amylase levels of less than 5000 IU on the first day after surgery, the early removal group (n=81) had fewer complications and shorter hospital stays than the late removal group (n=257) (30.9% vs 54.5%, p < 0.001; 9.8 days vs 12.5 days, p = 0.030, respectively). The incidence rates of specific complications including CR-POPFs were comparable between the two groups. Risk factor analysis showed that early drain removal did not increase the risk of CR-POPFs (p = 0.163).
Although early drain removal after PD has not been identified as apparently beneficial, this study showed that it may contribute to an early return to normal life without increasing complications.
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