East African countries (Uganda, Kenya, Tanzania, Rwanda, and Burundi) are prone to weather extreme events. In this regard; the past occurrence of extreme rainfall events is analyzed for 25 stations following the Expert Team on Climate Change Detection and Indices (ETCCDI) regression method. Detrended Fluctuation Analysis (DFA) is used to show the future development of extreme events. Pearson’s correlation analysis is performed to show the relationship of extreme events between different rainfall zones and their association with El Niño -Southern Oscillation (ENSO and Indian Ocean dipole (IOD) IOD-DMI indices. Results revealed that the consecutive wet day's index (CWD) was decreasing trend in 72% of the stations analyzed, moreover consecutive dry days (CDD) index also indicated a positive trend in 44% of the stations analyzed. Heavy rainfall days index (R10mm) showed a positive trend at 52% of the stations and was statistically significant at a few stations. In light of the extremely heavy rainfall days (R25mm) index, 56% of the stations revealed a decreasing trend for the index and statistically significant trend at some stations. Further, a low correlation coefficient of extreme rainfall events in the regions; and between rainfall extreme indices with the atmospheric teleconnection indices (Dipole Mode Index-DMI and Nino 3.4) (r = -0.1 to r = 0.35). Most rainfall zones showed a positive correlation between the R95p index and DMI, while 5/8 of the rainfall zones experienced a negative correlation between Nino 3.4 index and the R95p. In light of the highly variable trends of extremes events, we recommend planning adaptation and mitigation measures that consider the occurrence of such high variability. Measures such as rainwater harvesting, stored and used during needs, planned settlement, and improved drainage systems management supported by accurate climate and weather forecasts is highly advised.