This preprint is under consideration at Breast Cancer Research and Treatment. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research Article
Xiaoshuang Feng
Fudan University Shanghai Cancer Center
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7933-3996
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: To examine the differences in long-term survival between male and matched female breast cancer cases based on data from the Shanghai Cancer Registry (SCR).
Methods: Every male breast cancer case was matched with four female cases according to the year of diagnosis, age, tumor stage, and histological subtype. Cumulative observed overall survival (OS) and cancer-specific survival (CSS) rates were calculated using Kaplan-Meier survival estimates, and log-rank tests were applied to compare the survival rates of male and female cases. Cox proportional-hazards regression models were used to assess the hazard ratios (HR) and 95% confidence intervals (CI) for the association between sex and the risk of death.
Results: 50,958 patients with breast cancer (0.85% male) were registered in the SCR between 2002 and 2013. After matching, 434 male and 1736 female patients were included in the study. With a median follow-up time of 10 years, men with breast cancer showed significantly worse OS (P < 0.0001) and CSS (P < 0.0001) than women. The 5- and 10-year OS rates for male and female patients were 67.27% and 77.75%, and 45.95% and 62.60%, respectively; the 5- and 10-year CSS rates for male and female patients were 70.19% and 79.79%, and 50.57% and 67.20%, respectively. Compared with women, men had 65% increased risk of overall death (95% CI: 1.42-1.92) and 70% increased risk of cancer-specific death (95% CI: 1.44-2.00).
Conclusion: The study provided evidence at the population level that male patients with breast cancer had lower survival rates than women in China.
Keywords
Male breast cancer, female breast cancer, long-term survival, matched-pair analysis
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This preprint is under consideration at Breast Cancer Research and Treatment. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Xiaoshuang Feng
Fudan University Shanghai Cancer Center
Corresponding Author
ORCiD: https://orcid.org/0000-0002-7933-3996
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 09 Mar, 2021
No community comments so far
Reviewers invited
Invitations sent on 01 Mar, 2021
First submitted
On 24 Feb, 2021
Editor assigned
On 23 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Purpose: To examine the differences in long-term survival between male and matched female breast cancer cases based on data from the Shanghai Cancer Registry (SCR).
Methods: Every male breast cancer case was matched with four female cases according to the year of diagnosis, age, tumor stage, and histological subtype. Cumulative observed overall survival (OS) and cancer-specific survival (CSS) rates were calculated using Kaplan-Meier survival estimates, and log-rank tests were applied to compare the survival rates of male and female cases. Cox proportional-hazards regression models were used to assess the hazard ratios (HR) and 95% confidence intervals (CI) for the association between sex and the risk of death.
Results: 50,958 patients with breast cancer (0.85% male) were registered in the SCR between 2002 and 2013. After matching, 434 male and 1736 female patients were included in the study. With a median follow-up time of 10 years, men with breast cancer showed significantly worse OS (P < 0.0001) and CSS (P < 0.0001) than women. The 5- and 10-year OS rates for male and female patients were 67.27% and 77.75%, and 45.95% and 62.60%, respectively; the 5- and 10-year CSS rates for male and female patients were 70.19% and 79.79%, and 50.57% and 67.20%, respectively. Compared with women, men had 65% increased risk of overall death (95% CI: 1.42-1.92) and 70% increased risk of cancer-specific death (95% CI: 1.44-2.00).
Conclusion: The study provided evidence at the population level that male patients with breast cancer had lower survival rates than women in China.
Figure 1
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