This preprint is under consideration at Cardiovascular Ultrasound. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Lina SUN
China-Japan Union Hospital of Jilin University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2210-7063
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
The novel noninvasive pressure-strain loop (PSL) is a reliable tool that reflects myocardial work (MW). Systolic blood pressure (SBP) is the only independent factor for MW indices. However, afterload-related reference values have not been previously reported. The aim of the present study was to establish reference values for MW parameters by SBP grading over a wide range.
Methods
We prospectively selected healthy individuals and subjects with SBP ≥ 140mmHg at the time of study without myocardial remodeling. MW parameters were collected and the reference values achieved were grouped by SBP in 10-mmHg.
Results
Significant differences were noted among the SBP-groups for global work index (GWI) and global constructive work (GCW). The majority of statistical comparisons of the differences in GWI and GCW were significant at each SBP-group. With SBP ranging from 90 to 189mmHg, the parameters GWI and GCW tended to increase linearly with afterload. Overall, the global wasted work (GWW) tended to rise as SBP was increased, but not all of the differences noted in GWW were significant for each SBP-group. Global work efficiency (GWE) remained stable across all SBP-groups, with the exception of a slight drop noted when it exceeded 160 mmHg.
Conclusions
Keywords
myocardial work, afterload, reference values
Figure 1
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 04 Mar, 2021
No community comments so far
Editorial decision: Minor revision
On 21 Mar, 2021
Review #2 received
Received 15 Mar, 2021
Review #1 received
Received 05 Mar, 2021
Reviewer #2 agreed
On 01 Mar, 2021
Reviews received
Received 01 Mar, 2021
Reviewers invited
Invitations sent on 01 Mar, 2021
Reviewer #1 agreed
On 01 Mar, 2021
Submission checks complete
On 27 Feb, 2021
Editor invited
On 27 Feb, 2021
Editor assigned
On 24 Feb, 2021
First submitted
On 24 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
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This preprint is under consideration at Cardiovascular Ultrasound. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Lina SUN
China-Japan Union Hospital of Jilin University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2210-7063
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 04 Mar, 2021
No community comments so far
Editorial decision: Minor revision
On 21 Mar, 2021
Review #2 received
Received 15 Mar, 2021
Review #1 received
Received 05 Mar, 2021
Reviewer #2 agreed
On 01 Mar, 2021
Reviews received
Received 01 Mar, 2021
Reviewers invited
Invitations sent on 01 Mar, 2021
Reviewer #1 agreed
On 01 Mar, 2021
Submission checks complete
On 27 Feb, 2021
Editor invited
On 27 Feb, 2021
Editor assigned
On 24 Feb, 2021
First submitted
On 24 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
The novel noninvasive pressure-strain loop (PSL) is a reliable tool that reflects myocardial work (MW). Systolic blood pressure (SBP) is the only independent factor for MW indices. However, afterload-related reference values have not been previously reported. The aim of the present study was to establish reference values for MW parameters by SBP grading over a wide range.
Methods
We prospectively selected healthy individuals and subjects with SBP ≥ 140mmHg at the time of study without myocardial remodeling. MW parameters were collected and the reference values achieved were grouped by SBP in 10-mmHg.
Results
Significant differences were noted among the SBP-groups for global work index (GWI) and global constructive work (GCW). The majority of statistical comparisons of the differences in GWI and GCW were significant at each SBP-group. With SBP ranging from 90 to 189mmHg, the parameters GWI and GCW tended to increase linearly with afterload. Overall, the global wasted work (GWW) tended to rise as SBP was increased, but not all of the differences noted in GWW were significant for each SBP-group. Global work efficiency (GWE) remained stable across all SBP-groups, with the exception of a slight drop noted when it exceeded 160 mmHg.
Conclusions
Figure 1
Figure 2
Figure 3
This is a list of supplementary files associated with this preprint. Click to download.
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