This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Tingzhong Wang
First Affiliated Hospital of Xi'an Jiaotong University
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: Numerous patients with ST-segment elevation myocardial infarction (STEMI), especially in developing countries, undergo late percutaneous coronary intervention (PCI), defined as time of PCI > 24 hours from symptom onset. This study is aimed to identify the predictive value of admission blood urea nitrogen/creatinine ratio (BUN/Cr) on long-term all-cause mortality and cardiac mortality in STEMI patients receiving late PCI.
Methods: Eligible STEMI patients who received late PCI between 2009 and 2011 were consecutively enrolled. They were classified into two groups based on the median BUN/Cr: low BUN/Cr group and high BUN/Cr group. Patients were followed up by phone or face to face interviews and medical records review. The primary endpoint was defined as all-cause mortality and cardiac mortality.
Results: 780 STEMI patients were enrolled finally. The median BUN/Cr was 14.29. The median follow-up period was 41 months, with 37 all-cause deaths and 25 cardiac deaths. Compared to the low BUN/Cr group, high BUN/Cr group had higher all-cause mortality (6.4% vs. 3.1%, P=0.029), and cardiac mortality (6.3% vs. 1.5%, P<0.001). The Cox proportional hazard analysis revealed that high BUN/Cr at admission was an independent predictor of long-term cardiac mortality (P=0.003), but not of all-cause mortality (P=0.077).
Conclusions: High BUN/Cr ratio at admission was an independent predictor of cardiac mortality in STEMI patients receiving late PCI.
Brief Summary: In a retrospective study of STEMI patients receiving late PCI, we found that high BUN/Cr ratio (BUN/Cr>14.29) at admission was an independent predictor of long-term cardiac mortality, but not of all-cause mortality. The study showed that BUN/Cr ratio could be a potential indicator of risk stratification models for STEMI patients undergoing late PCI.
Keywords
blood urea nitrogen/creatinine ratio, long-term prognosis, ST-segment elevation myocardialinfarction,latepercutaneouscoronaryintervention
Figure 1
Figure 2
Figure 3
Figure 4
Loading...
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Mar, 2021
No community comments so far
Review #1 received
Received 18 Mar, 2021
Review #3 received
Received 18 Mar, 2021
Review #4 received
Received 18 Mar, 2021
Reviewer #2 agreed
On 08 Mar, 2021
Reviewer #6 agreed
On 08 Mar, 2021
Reviewer #8 agreed
On 08 Mar, 2021
Reviewer #3 agreed
On 08 Mar, 2021
Reviewer #9 agreed
On 08 Mar, 2021
Reviewer #4 agreed
On 08 Mar, 2021
Reviewer #1 agreed
On 08 Mar, 2021
Reviewer #5 agreed
On 08 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Editor assigned
On 06 Mar, 2021
Editor invited
On 04 Mar, 2021
Submission checks complete
On 04 Mar, 2021
First submitted
On 25 Feb, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Cardiac & Cardiovascular Systems
Learn more about our company.
This preprint is under consideration at BMC Cardiovascular Disorders. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Tingzhong Wang
First Affiliated Hospital of Xi'an Jiaotong University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 11 Mar, 2021
No community comments so far
Review #1 received
Received 18 Mar, 2021
Review #3 received
Received 18 Mar, 2021
Review #4 received
Received 18 Mar, 2021
Reviewer #2 agreed
On 08 Mar, 2021
Reviewer #6 agreed
On 08 Mar, 2021
Reviewer #8 agreed
On 08 Mar, 2021
Reviewer #3 agreed
On 08 Mar, 2021
Reviewer #9 agreed
On 08 Mar, 2021
Reviewer #4 agreed
On 08 Mar, 2021
Reviewer #1 agreed
On 08 Mar, 2021
Reviewer #5 agreed
On 08 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Editor assigned
On 06 Mar, 2021
Editor invited
On 04 Mar, 2021
Submission checks complete
On 04 Mar, 2021
First submitted
On 25 Feb, 2021
Subject Areas
Cardiac & Cardiovascular Systems
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: Numerous patients with ST-segment elevation myocardial infarction (STEMI), especially in developing countries, undergo late percutaneous coronary intervention (PCI), defined as time of PCI > 24 hours from symptom onset. This study is aimed to identify the predictive value of admission blood urea nitrogen/creatinine ratio (BUN/Cr) on long-term all-cause mortality and cardiac mortality in STEMI patients receiving late PCI.
Methods: Eligible STEMI patients who received late PCI between 2009 and 2011 were consecutively enrolled. They were classified into two groups based on the median BUN/Cr: low BUN/Cr group and high BUN/Cr group. Patients were followed up by phone or face to face interviews and medical records review. The primary endpoint was defined as all-cause mortality and cardiac mortality.
Results: 780 STEMI patients were enrolled finally. The median BUN/Cr was 14.29. The median follow-up period was 41 months, with 37 all-cause deaths and 25 cardiac deaths. Compared to the low BUN/Cr group, high BUN/Cr group had higher all-cause mortality (6.4% vs. 3.1%, P=0.029), and cardiac mortality (6.3% vs. 1.5%, P<0.001). The Cox proportional hazard analysis revealed that high BUN/Cr at admission was an independent predictor of long-term cardiac mortality (P=0.003), but not of all-cause mortality (P=0.077).
Conclusions: High BUN/Cr ratio at admission was an independent predictor of cardiac mortality in STEMI patients receiving late PCI.
Brief Summary: In a retrospective study of STEMI patients receiving late PCI, we found that high BUN/Cr ratio (BUN/Cr>14.29) at admission was an independent predictor of long-term cardiac mortality, but not of all-cause mortality. The study showed that BUN/Cr ratio could be a potential indicator of risk stratification models for STEMI patients undergoing late PCI.
Figure 1
Figure 2
Figure 3
Figure 4
Loading...