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Research Article
Tobias Braun
Department of Neurology, University Hospital Giessen and Marburg Campus Giessen
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Dysphagia is common in neurological disease. However, our understanding of swallowing and its central nervous control is limited. Sensory information plays a vital role in the initiation of the swallowing reflex and is often reduced in stroke patients. We hypothesized that the sensitivity threshold of the anterior faucial pillar could be facilitated by either electrical stimulation (ES) or taste and smell information.
Methods
The sensitivity threshold was measured by ES in the anterior faucial pillar region. The measurement was repeated 5 minutes after baseline. Thirty minutes after baseline, the participants underwent a test for taste and smell. Immediately after the test, the ES was repeated.
Results
Thirty healthy volunteers with a mean age of 27±5.1 participated in the trial. Mean sensitivity threshold at baseline was 1.9mA ± 0.59mA. The values 5 minutes after baseline (1.74mA ± 0.56mA, p=0.027) and 30 minutes after baseline (1.67mA ± 0.58mA, p=0.011) were significantly lower compared to the baseline, but there was no difference between the latter (p=0.321).
Conclusion
After 5 minutes, a potentially facilitating effect was found on oral sensitivity by ES of the faucial pillar area. Thirty minutes later, this effect was still present.
Keywords
meausurement, electrical stimulation, oral sensitivity, anterior faucial pillar, taste and smell, facilitation
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CURRENT STATUS: Under Revision
Version 1
Posted 15 Mar, 2021
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Editorial decision: Major revision
On 09 Apr, 2021
Review #3 received
Received 24 Mar, 2021
Review #4 received
Received 24 Mar, 2021
Review #2 received
Received 24 Mar, 2021
Review #1 received
Received 24 Mar, 2021
Reviewer #2 agreed
On 08 Mar, 2021
Reviewer #7 agreed
On 08 Mar, 2021
Reviewer #8 agreed
On 08 Mar, 2021
Reviewer #4 agreed
On 08 Mar, 2021
Reviewer #6 agreed
On 08 Mar, 2021
Reviewer #3 agreed
On 08 Mar, 2021
Reviewer #1 agreed
On 08 Mar, 2021
Reviewer #5 agreed
On 08 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Editor assigned
On 08 Mar, 2021
Editor invited
On 03 Mar, 2021
Submission checks complete
On 03 Mar, 2021
First submitted
On 26 Feb, 2021
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This preprint is under consideration at Scientific Reports. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Tobias Braun
Department of Neurology, University Hospital Giessen and Marburg Campus Giessen
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 15 Mar, 2021
No community comments so far
Editorial decision: Major revision
On 09 Apr, 2021
Review #3 received
Received 24 Mar, 2021
Review #4 received
Received 24 Mar, 2021
Review #2 received
Received 24 Mar, 2021
Review #1 received
Received 24 Mar, 2021
Reviewer #2 agreed
On 08 Mar, 2021
Reviewer #7 agreed
On 08 Mar, 2021
Reviewer #8 agreed
On 08 Mar, 2021
Reviewer #4 agreed
On 08 Mar, 2021
Reviewer #6 agreed
On 08 Mar, 2021
Reviewer #3 agreed
On 08 Mar, 2021
Reviewer #1 agreed
On 08 Mar, 2021
Reviewer #5 agreed
On 08 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Editor assigned
On 08 Mar, 2021
Editor invited
On 03 Mar, 2021
Submission checks complete
On 03 Mar, 2021
First submitted
On 26 Feb, 2021
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
Dysphagia is common in neurological disease. However, our understanding of swallowing and its central nervous control is limited. Sensory information plays a vital role in the initiation of the swallowing reflex and is often reduced in stroke patients. We hypothesized that the sensitivity threshold of the anterior faucial pillar could be facilitated by either electrical stimulation (ES) or taste and smell information.
Methods
The sensitivity threshold was measured by ES in the anterior faucial pillar region. The measurement was repeated 5 minutes after baseline. Thirty minutes after baseline, the participants underwent a test for taste and smell. Immediately after the test, the ES was repeated.
Results
Thirty healthy volunteers with a mean age of 27±5.1 participated in the trial. Mean sensitivity threshold at baseline was 1.9mA ± 0.59mA. The values 5 minutes after baseline (1.74mA ± 0.56mA, p=0.027) and 30 minutes after baseline (1.67mA ± 0.58mA, p=0.011) were significantly lower compared to the baseline, but there was no difference between the latter (p=0.321).
Conclusion
After 5 minutes, a potentially facilitating effect was found on oral sensitivity by ES of the faucial pillar area. Thirty minutes later, this effect was still present.
Figure 1
Figure 2
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