This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Dandan Yan
Shanghai Sixth Peoples Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9799-3325
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Our study aimed to analyse the characteristics of glucose and lipid metabolism in a healthy Han and Kazakh population in Barkol Kazakh Autonomous County.
Methods: We enrolled 4,400 subjects in Barkol Kazakh Autonomous County. The patients’ basic characteristics were recorded, chemical parameters were tested, and the characteristics of glucose and lipid metabolism between the Han and Kazakh ethnic groups were evaluated.
Results: We found significant differences in glucose and lipid metabolism between Han and Kazakh people; individuals of the Han ethnicity had higher FPG and TGs but lower BMI, blood pressure, TC and LDL-C than those of the Kazakh ethnicity. Similar results remained after the participants were divided by sex. Regarding the detection rate of metabolic disorders, we observed higher rates of glucose and TG disorders but lower rates of TC, HDL-C and LDL-C disorders in individuals of the Han ethnicity than in those of the Kazakh ethnicity. For atherosclerotic cardiovascular disease (ASCVD) risk, the detection rate of an LDL-C level ≥ 4.1 mmol/L was significantly higher in Kazakh individuals than in Han individuals. However, regarding hyperglycaemic patients aged 40 years orolder with 1.8 ≤ LDL-C ≤ 4.9 mmol/L, the detection rate was higher in the Han individuals than in the Kazakh individuals. Similar results were also observed after we divided these participants by sex.
Conclusion: Our study evaluated metabolic disorders in the Han and Kazakh people in Balikun County and found that metabolic disorders showed sex, ethnic and metabolite component heterogeneity.
Keywords
Metabolism disorder, Han ethnicity, Kazakh ethnicity, ASCVD risk
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Research article
Dandan Yan
Shanghai Sixth Peoples Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0001-9799-3325
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 18 May, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Our study aimed to analyse the characteristics of glucose and lipid metabolism in a healthy Han and Kazakh population in Barkol Kazakh Autonomous County.
Methods: We enrolled 4,400 subjects in Barkol Kazakh Autonomous County. The patients’ basic characteristics were recorded, chemical parameters were tested, and the characteristics of glucose and lipid metabolism between the Han and Kazakh ethnic groups were evaluated.
Results: We found significant differences in glucose and lipid metabolism between Han and Kazakh people; individuals of the Han ethnicity had higher FPG and TGs but lower BMI, blood pressure, TC and LDL-C than those of the Kazakh ethnicity. Similar results remained after the participants were divided by sex. Regarding the detection rate of metabolic disorders, we observed higher rates of glucose and TG disorders but lower rates of TC, HDL-C and LDL-C disorders in individuals of the Han ethnicity than in those of the Kazakh ethnicity. For atherosclerotic cardiovascular disease (ASCVD) risk, the detection rate of an LDL-C level ≥ 4.1 mmol/L was significantly higher in Kazakh individuals than in Han individuals. However, regarding hyperglycaemic patients aged 40 years orolder with 1.8 ≤ LDL-C ≤ 4.9 mmol/L, the detection rate was higher in the Han individuals than in the Kazakh individuals. Similar results were also observed after we divided these participants by sex.
Conclusion: Our study evaluated metabolic disorders in the Han and Kazakh people in Balikun County and found that metabolic disorders showed sex, ethnic and metabolite component heterogeneity.
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