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Research Article
Shaoqiang Huang
Obstetrics and Gynecology Hospital of Fudan University
Corresponding Author
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Background：Hypotension after neuraxial anaesthesia is one of the most common complications during caesarean section. Vasopressors are generally agreed to be the most effective way to improve hypotension, but it is unclear which of these drugs is best for caesarean section. We assessed the effects of vasopressors on the contractile response of uterine arteries and superior mesenteric arteries in pregnant rats, with the goal of identifying a drug that raises the blood pressure of the systemic circulation while minimally affecting the uterine and placental circulation.
Methods： Isolated ring segments from the uterine and superior mesenteric arteries of pregnant rats were mounted in organ baths, and their contractile responses to several vasopressor agents were studied. Concentration-response curves for norepinephrine, phenylephrine, metaraminol and vasopressin were constructed.
Results：The experimental results showed that the contractile response of the mesenteric artery to norepinephrine, as measured by the pEC50 of the drug, was stronger than that of the uterine artery (5.617 ± 0.11 vs. 4.493 ± 1.35, p=0.009), and the contractile response of the uterine artery to metaraminol was stronger than that of the mesenteric artery (pEC50: 5.084±0.17 vs 4.92±0.10, p=0.007). There was no statistically significant difference in the pEC50 of phenylephrine or vasopressin between the two blood vessels.
Conclusion： In vitro experiments show that compared with phenylephrine, metaraminol , vasopressin, norepinephrine can contract peripheral blood vessel more strongly, while having the least effect on the contraction of uterine artery. These findings provide some support for the use of norepinephrine in mothers between the time of neuraxial anaesthesia and the delivery of the foetus.
Keywords
Vasopressor, Mesenteric artery, Uterine artery, Contraction
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Reviewer #5 agreed
On 06 Apr, 2021
Reviewer #3 agreed
On 04 Apr, 2021
Reviewer #1 agreed
On 04 Apr, 2021
Reviewer #6 agreed
On 04 Apr, 2021
Reviewer #2 agreed
On 04 Apr, 2021
Reviewer #4 agreed
On 04 Apr, 2021
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Invitations sent on 04 Apr, 2021
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Editor invited
On 16 Mar, 2021
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Subject Areas
Anesthesiology & Pain Medicine
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This preprint is under consideration at BMC Anesthesiology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research Article
Shaoqiang Huang
Obstetrics and Gynecology Hospital of Fudan University
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 17 Mar, 2021
No community comments so far
Review #1 received
Received 06 Apr, 2021
Review #4 received
Received 06 Apr, 2021
Review #2 received
Received 06 Apr, 2021
Reviewer #5 agreed
On 06 Apr, 2021
Reviewer #3 agreed
On 04 Apr, 2021
Reviewer #1 agreed
On 04 Apr, 2021
Reviewer #6 agreed
On 04 Apr, 2021
Reviewer #2 agreed
On 04 Apr, 2021
Reviewer #4 agreed
On 04 Apr, 2021
Reviewers invited
Invitations sent on 04 Apr, 2021
Editor assigned
On 02 Apr, 2021
Editor invited
On 16 Mar, 2021
Submission checks complete
On 16 Mar, 2021
First submitted
On 27 Feb, 2021
Subject Areas
Anesthesiology & Pain Medicine
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background：Hypotension after neuraxial anaesthesia is one of the most common complications during caesarean section. Vasopressors are generally agreed to be the most effective way to improve hypotension, but it is unclear which of these drugs is best for caesarean section. We assessed the effects of vasopressors on the contractile response of uterine arteries and superior mesenteric arteries in pregnant rats, with the goal of identifying a drug that raises the blood pressure of the systemic circulation while minimally affecting the uterine and placental circulation.
Methods： Isolated ring segments from the uterine and superior mesenteric arteries of pregnant rats were mounted in organ baths, and their contractile responses to several vasopressor agents were studied. Concentration-response curves for norepinephrine, phenylephrine, metaraminol and vasopressin were constructed.
Results：The experimental results showed that the contractile response of the mesenteric artery to norepinephrine, as measured by the pEC50 of the drug, was stronger than that of the uterine artery (5.617 ± 0.11 vs. 4.493 ± 1.35, p=0.009), and the contractile response of the uterine artery to metaraminol was stronger than that of the mesenteric artery (pEC50: 5.084±0.17 vs 4.92±0.10, p=0.007). There was no statistically significant difference in the pEC50 of phenylephrine or vasopressin between the two blood vessels.
Conclusion： In vitro experiments show that compared with phenylephrine, metaraminol , vasopressin, norepinephrine can contract peripheral blood vessel more strongly, while having the least effect on the contraction of uterine artery. These findings provide some support for the use of norepinephrine in mothers between the time of neuraxial anaesthesia and the delivery of the foetus.
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This preprint is available for download as a PDF.
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