The aim of the study was to investigate the quality of life of Rzeszow residents aged 18-75 using a WHOQOL-BREF questionnaire which consists of 26 questions and analyses 4 basic domains of quality of life: physical, psychological, social relationships, functional environment of the respondent and a global quality of life and self-assessment of one’s health. The survey was conducted on a representative sample of 618 adult residents of Rzeszow. Respondents were randomly selected through systematic random sampling with latent layer division from the population register shared by Rzeszow Municipal Office. The analysis of factors differentiating the residents’ assessment of quality of life was based on socio-demographic variables such as gender, age and education and variables representing social factors - financial situation and body mass index (BMI). The results indicate that gender does not differentiate the quality of life of Rzeszow residents. However, the quality of life is affected by age, education, financial situation, and body mass index.