This preprint is under consideration at World Journal of Surgical Oncology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
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Research
Gu Lei
Renji hospital
Corresponding Author
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: To explore the pathological characteristics of lymph nodes around inferior mesenteric artery in rectal cancer, and to explore its risk factors and its impact on tumor staging.
Methods: Cases of rectal cancer patients underwent proctectomy surgery were collected in this study. Clinical features of patients, including gender, age, BMI, tumor size, pathological type, differentiation, nerve invasion, lymph nodes, tumor marker and pathological examinations were analyzed.
Results: A total of 485 cases were included in this study. There were 29 cases with IMA-LN metastasis, the metastasis rate was 5.98% (29/485). Positive IMA-LNs were associated with distance from anal verge, CEA, pathological type, differentiation, nerve invasion, T stage and N stage. Multivariate analysis showed that distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs.
Conclusion: Distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs. No skip metastasis occurred in IMA-LNs. We should choose the appropriate surgical methods to achieve better oncological results and reduce the incidence of postoperative complications.
Keywords
Rectal cancer, Lymph nodes metastasis, High ligation, Inferior mesenteric artery, Pathological features
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CURRENT STATUS: Under Revision
Version 1
Posted 10 Mar, 2021
No community comments so far
Editorial decision: Major Revision
On 04 Apr, 2021
Review #3 received
Received 22 Mar, 2021
Review #1 received
Received 19 Mar, 2021
Reviewer #4 agreed
On 16 Mar, 2021
Review #2 received
Received 14 Mar, 2021
Reviewer #3 agreed
On 13 Mar, 2021
Reviewer #2 agreed
On 13 Mar, 2021
Review #? received
Received 10 Mar, 2021
Reviewer #1 agreed
On 10 Mar, 2021
Reviewers invited
Invitations sent on 07 Mar, 2021
Submission checks complete
On 07 Mar, 2021
Editor assigned
On 06 Mar, 2021
Editor invited
On 06 Mar, 2021
First submitted
On 28 Feb, 2021
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This preprint is under consideration at World Journal of Surgical Oncology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research
Gu Lei
Renji hospital
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Revision
Version 1
Posted 10 Mar, 2021
No community comments so far
Editorial decision: Major Revision
On 04 Apr, 2021
Review #3 received
Received 22 Mar, 2021
Review #1 received
Received 19 Mar, 2021
Reviewer #4 agreed
On 16 Mar, 2021
Review #2 received
Received 14 Mar, 2021
Reviewer #3 agreed
On 13 Mar, 2021
Reviewer #2 agreed
On 13 Mar, 2021
Review #? received
Received 10 Mar, 2021
Reviewer #1 agreed
On 10 Mar, 2021
Reviewers invited
Invitations sent on 07 Mar, 2021
Submission checks complete
On 07 Mar, 2021
Editor assigned
On 06 Mar, 2021
Editor invited
On 06 Mar, 2021
First submitted
On 28 Feb, 2021
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective: To explore the pathological characteristics of lymph nodes around inferior mesenteric artery in rectal cancer, and to explore its risk factors and its impact on tumor staging.
Methods: Cases of rectal cancer patients underwent proctectomy surgery were collected in this study. Clinical features of patients, including gender, age, BMI, tumor size, pathological type, differentiation, nerve invasion, lymph nodes, tumor marker and pathological examinations were analyzed.
Results: A total of 485 cases were included in this study. There were 29 cases with IMA-LN metastasis, the metastasis rate was 5.98% (29/485). Positive IMA-LNs were associated with distance from anal verge, CEA, pathological type, differentiation, nerve invasion, T stage and N stage. Multivariate analysis showed that distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs.
Conclusion: Distance from anal verge, CEA level, differentiation, and T stage were independent risk factors for positive IMA-LNs. No skip metastasis occurred in IMA-LNs. We should choose the appropriate surgical methods to achieve better oncological results and reduce the incidence of postoperative complications.
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