Objective: To explore the early clinical characteristics of coronavirus disease 2019 (COVID-19) and provide a reference for the early prevention and treatment of the disease.
Methods: We collected and analyzed demographic data, medical history, exposure history, underline diseases, symptoms, signs, laboratory data, chest computed tomographic (CT) scans, and treatment measures of COVID-19 patients admitted to the Sixth People's Hospital of Hangzhou from January 20 to February 23, 2020.
Results: Among 51 confirmed COVID-19 patients included in this study, 7.8% (4/51) patients were severe and 45.1% (23/51) were male. Median age was 43 years (IQR, 23). Fever (54.9%, 28/51) and cough (52.9%, 27/51) were the main symptoms. 74.5% (38/51) patients had a history of exposure and 17.6% (9/51) patients had a history of hypertension. Importantly, most (60.8%, 31/51) patients had an increase of urine β2 microglobulin. In addition, the inflammation indexes (C-reactive protein and serum amyloid A) of patients with elevated urine β2 microglobulin were significantly increased (p = 0.017 and p = 0.049) and lymphocytes count was significantly reduced (p = 0.012), compared with patients with normal urine β2 microglobulin. Correlation analysis showed that urine β2 microglobulin was positively correlated with C-reactive protein and serum amyloid A; but negatively correlated with lymphocytes count.
Conclusions: COVID-19 patients have obvious symptoms of lung injury, but the occurrence of early renal tubular injuries has to be monitored vigilantly.