Ailawadi, G., Moehle, C.W., Pei, H., Walton, S.P., Yang, Z., Kron, I.L., Lau, C.L., and Owens, G.K. (2009). Smooth muscle phenotypic modulation is an early event in aortic aneurysms. J Thorac Cardiovasc Surg 138, 1392-1399.
Bennett, M.R., Sinha, S., and Owens, G.K. (2016). Vascular Smooth Muscle Cells in Atherosclerosis. Circ Res 118, 692-702.
Byon, C.H., Sun, Y., Chen, J., Yuan, K., Mao, X., Heath, J.M., Anderson, P.G., Tintut, Y., Demer, L.L., Wang, D., and Chen, Y. (2011). Runx2-upregulated receptor activator of nuclear factor kappaB ligand in calcifying smooth muscle cells promotes migration and osteoclastic differentiation of macrophages. Arterioscler Thromb Vasc Biol 31, 1387-1396.
Carreira, A.C., Alves, G.G., Zambuzzi, W.F., Sogayar, M.C., and Granjeiro, J.M. (2014). Bone Morphogenetic Proteins: structure, biological function and therapeutic applications. Arch Biochem Biophys 561, 64-73.
Daugherty, A., Manning, M.W., and Cassis, L.A. (2000). Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 105, 1605-1612.
Dihlmann, S., Erhart, P., Mehrabi, A., Nickkholgh, A., Lasitschka, F., Bockler, D., and Hakimi, M. (2014). Increased expression and activation of absent in melanoma 2 inflammasome components in lymphocytic infiltrates of abdominal aortic aneurysms. Mol Med 20, 230-237.
Fernandes-Alnemri, T., Yu, J.W., Datta, P., Wu, J., and Alnemri, E.S. (2009). AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature 458, 509-513.
Freise, C., Kretzschmar, N., and Querfeld, U. (2016). Wnt signaling contributes to vascular calcification by induction of matrix metalloproteinases. BMC Cardiovasc Disord 16, 185.
Gardner, S.E., Humphry, M., Bennett, M.R., and Clarke, M.C. (2015). Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1alpha-Dependent Senescence-Associated Secretory Phenotype. Arterioscler Thromb Vasc Biol 35, 1963-1974.
Golledge, J. (2019). Abdominal aortic aneurysm: update on pathogenesis and medical treatments. Nat Rev Cardiol 16, 225-242.
Hakimi, M., Peters, A., Becker, A., Bockler, D., and Dihlmann, S. (2014). Inflammation-related induction of absent in melanoma 2 (AIM2) in vascular cells and atherosclerotic lesions suggests a role in vascular pathogenesis. J Vasc Surg 59, 794-803 e792.
Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D.R., Latz, E., and Fitzgerald, K.A. (2009). AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 458, 514-518.
Hortells, L., Sur, S., and St Hilaire, C. (2018). Cell Phenotype Transitions in Cardiovascular Calcification. Front Cardiovasc Med 5, 27.
Jiang, Y., Wang, M., Huang, K., Zhang, Z., Shao, N., Zhang, Y., Wang, W., and Wang, S. (2012). Oxidized low-density lipoprotein induces secretion of interleukin-1beta by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation. Biochem Biophys Res Commun 425, 121-126.
Johnston, W.F., Salmon, M., Pope, N.H., Meher, A., Su, G., Stone, M.L., Lu, G., Owens, G.K., Upchurch, G.R., Jr., and Ailawadi, G. (2014). Inhibition of interleukin-1beta decreases aneurysm formation and progression in a novel model of thoracic aortic aneurysms. Circulation 130, S51-59.
Johnston, W.F., Salmon, M., Su, G., Lu, G., Stone, M.L., Zhao, Y., Owens, G.K., Upchurch, G.R., Jr., and Ailawadi, G. (2013). Genetic and pharmacologic disruption of interleukin-1beta signaling inhibits experimental aortic aneurysm formation. Arterioscler Thromb Vasc Biol 33, 294-304.
Karsenty, G. (1999). The genetic transformation of bone biology. Genes & development 13, 3037-3051.
Kelly, M.J., Igari, K., and Yamanouchi, D. (2019). Osteoclast-Like Cells in Aneurysmal Disease Exhibit an Enhanced Proteolytic Phenotype. Int J Mol Sci 20.
Krishna, S.M., Seto, S.W., Jose, R.J., Li, J., Morton, S.K., Biros, E., Wang, Y., Nsengiyumva, V., Lindeman, J.H., Loots, G.G., et al. (2017). Wnt Signaling Pathway Inhibitor Sclerostin Inhibits Angiotensin II-Induced Aortic Aneurysm and Atherosclerosis. Arterioscler Thromb Vasc Biol 37, 553-566.
Li, X., Deroide, N., and Mallat, Z. (2014). The role of the inflammasome in cardiovascular diseases. J Mol Med (Berl) 92, 307-319.
Lindholt, J.S. (2008). Aneurysmal wall calcification predicts natural history of small abdominal aortic aneurysms. Atherosclerosis 197, 673-678.
Nakayama, A., Morita, H., Hayashi, N., Nomura, Y., Hoshina, K., Shigematsu, K., Ohtsu, H., Miyata, T., and Komuro, I. (2016). Inverse Correlation Between Calcium Accumulation and the Expansion Rate of Abdominal Aortic Aneurysms. Circ J 80, 332-339.
Owens, G.K., Kumar, M.S., and Wamhoff, B.R. (2004). Molecular regulation of vascular smooth muscle cell differentiation in development and disease. Physiol Rev 84, 767-801.
Petsophonsakul, P., Furmanik, M., Forsythe, R., Dweck, M., Schurink, G.W., Natour, E., Reutelingsperger, C., Jacobs, M., Mees, B., and Schurgers, L. (2019). Role of Vascular Smooth Muscle Cell Phenotypic Switching and Calcification in Aortic Aneurysm Formation. Arterioscler Thromb Vasc Biol 39, 1351-1368.
Raghavan, M.L., Kratzberg, J., Castro de Tolosa, E.M., Hanaoka, M.M., Walker, P., and da Silva, E.S. (2006). Regional distribution of wall thickness and failure properties of human abdominal aortic aneurysm. J Biomech 39, 3010-3016.
Reimerink, J.J., van der Laan, M.J., Koelemay, M.J., Balm, R., and Legemate, D.A. (2013). Systematic review and meta-analysis of population-based mortality from ruptured abdominal aortic aneurysm. Br J Surg 100, 1405-1413.
Ren, X.S., Tong, Y., Ling, L., Chen, D., Sun, H.J., Zhou, H., Qi, X.H., Chen, Q., Li, Y.H., Kang, Y.M., and Zhu, G.Q. (2017). NLRP3 Gene Deletion Attenuates Angiotensin II-Induced Phenotypic Transformation of Vascular Smooth Muscle Cells and Vascular Remodeling. Cell Physiol Biochem 44, 2269-2280.
Riches, K., Clark, E., Helliwell, R.J., Angelini, T.G., Hemmings, K.E., Bailey, M.A., Bridge, K.I., Scott, D.J.A., and Porter, K.E. (2018). Progressive Development of Aberrant Smooth Muscle Cell Phenotype in Abdominal Aortic Aneurysm Disease. J Vasc Res 55, 35-46.
Sampson, U.K., Norman, P.E., Fowkes, F.G., Aboyans, V., Yanna, S., Harrell, F.E., Jr., Forouzanfar, M.H., Naghavi, M., Denenberg, J.O., McDermott, M.M., et al. (2014). Global and regional burden of aortic dissection and aneurysms: mortality trends in 21 world regions, 1990 to 2010. Global heart 9, 171-180 e110.
Sharma, B.R., Karki, R., and Kanneganti, T.D. (2019). Role of AIM2 inflammasome in inflammatory diseases, cancer and infection. Eur J Immunol.
Sun, H.J., Ren, X.S., Xiong, X.Q., Chen, Y.Z., Zhao, M.X., Wang, J.J., Zhou, Y.B., Han, Y., Chen, Q., Li, Y.H., et al. (2017). NLRP3 inflammasome activation contributes to VSMC phenotypic transformation and proliferation in hypertension. Cell Death Dis 8, e3074.
Sun, W., Pang, Y., Liu, Z., Sun, L., Liu, B., Xu, M., Dong, Y., Feng, J., Jiang, C., Kong, W., and Wang, X. (2015). Macrophage inflammasome mediates hyperhomocysteinemia-aggravated abdominal aortic aneurysm. Journal of molecular and cellular cardiology 81, 96-106.
Takei, Y., Tanaka, T., Kent, K.C., and Yamanouchi, D. (2016). Osteoclastogenic Differentiation of Macrophages in the Development of Abdominal Aortic Aneurysms. Arterioscler Thromb Vasc Biol 36, 1962-1971.
Tanaka, T., Kelly, M., Takei, Y., and Yamanouchi, D. (2018). RANKL-mediated osteoclastogenic differentiation of macrophages in the abdominal aorta of angiotensin II-infused apolipoprotein E knockout mice. J Vasc Surg 68, 48S-59S e41.
Tang, Z., Wang, A., Yuan, F., Yan, Z., Liu, B., Chu, J.S., Helms, J.A., and Li, S. (2012). Differentiation of multipotent vascular stem cells contributes to vascular diseases. Nat Commun 3, 875.
Towler, D.A. (2017). "Osteotropic" Wnt/LRP Signals: High-Wire Artists in a Balancing Act Regulating Aortic Structure and Function. Arterioscler Thromb Vasc Biol 37, 392-395.
Usui, F., Shirasuna, K., Kimura, H., Tatsumi, K., Kawashima, A., Karasawa, T., Yoshimura, K., Aoki, H., Tsutsui, H., Noda, T., et al. (2015). Inflammasome activation by mitochondrial oxidative stress in macrophages leads to the development of angiotensin II-induced aortic aneurysm. Arterioscler Thromb Vasc Biol 35, 127-136.
Wen, C., Yang, X., Yan, Z., Zhao, M., Yue, X., Cheng, X., Zheng, Z., Guan, K., Dou, J., Xu, T., et al. (2013). Nalp3 inflammasome is activated and required for vascular smooth muscle cell calcification. Int J Cardiol 168, 2242-2247.
Wortmann, M., Skorubskaya, E., Peters, A.S., Hakimi, M., Bockler, D., and Dihlmann, S. (2019a). Necrotic cell debris induces a NF-kappaB-driven inflammasome response in vascular smooth muscle cells derived from abdominal aortic aneurysms (AAA-SMC). Biochem Biophys Res Commun 511, 343-349.
Wortmann, M., Xiao, X., Wabnitz, G., Samstag, Y., Hakimi, M., Bockler, D., and Dihlmann, S. (2019b). AIM2 levels and DNA-triggered inflammasome response are increased in peripheral leukocytes of patients with abdominal aortic aneurysm. Inflamm Res 68, 337-345.
Wu, D., Ren, P., Zheng, Y., Zhang, L., Xu, G., Xie, W., Lloyd, E.E., Zhang, S., Zhang, Q., Curci, J.A., et al. (2017). NLRP3 (Nucleotide Oligomerization Domain-Like Receptor Family, Pyrin Domain Containing 3)-Caspase-1 Inflammasome Degrades Contractile Proteins: Implications for Aortic Biomechanical Dysfunction and Aneurysm and Dissection Formation. Arterioscler Thromb Vasc Biol 37, 694-706.
Wu, X., Cakmak, S., Wortmann, M., Hakimi, M., Zhang, J., Bockler, D., and Dihlmann, S. (2016). Sex- and disease-specific inflammasome signatures in circulating blood leukocytes of patients with abdominal aortic aneurysm. Mol Med 22.
Wu, X., Hakimi, M., Wortmann, M., Zhang, J., Bockler, D., and Dihlmann, S. (2015). Gene expression of inflammasome components in peripheral blood mononuclear cells (PBMC) of vascular patients increases with age. Immunity & ageing : I & A 12, 15.