In this work, a drained bed reactor (TBR) was analyzed for the hydrotreatment process, using a commercial catalyst CoMo/\(\gamma\)-Al2O3, vegetable oil from Jatropha Curcas L. was used as raw material. The mode of operation of the reactor was considered in countercurrent. The operating conditions that were considered for the CFD simulation were temperature 320–380 ° C, pressure 8 MPag, LHSV 0.8–8.0 h− 1. The reactor model considers a single hydrocracking reaction of triglycerides to renewable fuels. The CFD simulation was carried out in Ansys Fluent 16.0 in transient state and in 3 dimensions, considering the turbulence model \(k- ϵ\) standard, Eulerian multiphase model for 3 phases and the porous medium model, obtaining results very similar to the experimental ones, a good approximation with the experimental results which can be applied to the industrial scale was shown.