In the 19th century, Cantor created the infinite cardinal number theory based on the "1-1 correspondence" principle. The continuum hypothesis is proposed under this theoretical framework. In 1900, Hilbert made it the first problem in his famous speech on mathematical problems, which shows the importance of this question. We know that the infinitesimal problem triggered the second mathematical crisis in the 17-18th centuries. The Infinity problem is no less important than the infinitesimal problem. In the 21st century, Sergeyev introduced the Grossone method from the principle of "whole is greater than part", and created another ruler for measuring infinite sets. Grossone theory shows that there is neither the largest infinity and infinitesimal, nor the smallest infinity and infinitesimal.