Background:
The vasoconstricting peptide endothelin-1 (ET-1) is associated with endothelial dysfunction. The aim of this paper was to investigate whether circulating ET-1 levels predicts chronic kidney disease (CKD) in a prospective population study.
Methods:
In 2002-2005, 2816 participants (30-74 years) were randomly selected from two municipalities in South-Western Sweden and followed up in a representative sample of 1327 individuals after ten years. Endothelin-1 levels were assessed at baseline. Outcome was defined as CKD stage 3 or above based on eGFR < 60 mL/min/1.73m2. Those 1314 participants with successful analysis of ET-1 were further analyzed using binary logistic regression.
Results:
At follow-up, 47 (7.2%) men and 63 (9.6%) women had CKD stage 3 and above. The level of ET-1 was divided into quintiles showing that women in the highest quintile (n=132) had a significantly increased risk of developing CKD during the follow up period (OR=2.379, 95% CI:1.23-4.61, p<0.01) compared with the other quintiles (1-4), even when adjusted for age, physical activity, current smoking, alcohol consumption, hypertension, diabetes, BMI, high- sensitive CRP and LDL-cholesterol (OR=2.66, 95% CI:1.29-5.49, p<0.01). No significant differences were observed between quintiles of ET-1 and development of CKD in men (NS).
Conclusions:
High levels of ET-1 are associated with development of CKD in women but not in men.
Figure 1
Figure 2
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Posted 18 Mar, 2021
Received 26 Mar, 2021
Received 26 Mar, 2021
On 24 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
Invitations sent on 11 Mar, 2021
On 11 Mar, 2021
On 11 Mar, 2021
On 11 Mar, 2021
On 08 Mar, 2021
Posted 18 Mar, 2021
Received 26 Mar, 2021
Received 26 Mar, 2021
On 24 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
On 20 Mar, 2021
Invitations sent on 11 Mar, 2021
On 11 Mar, 2021
On 11 Mar, 2021
On 11 Mar, 2021
On 08 Mar, 2021
Background:
The vasoconstricting peptide endothelin-1 (ET-1) is associated with endothelial dysfunction. The aim of this paper was to investigate whether circulating ET-1 levels predicts chronic kidney disease (CKD) in a prospective population study.
Methods:
In 2002-2005, 2816 participants (30-74 years) were randomly selected from two municipalities in South-Western Sweden and followed up in a representative sample of 1327 individuals after ten years. Endothelin-1 levels were assessed at baseline. Outcome was defined as CKD stage 3 or above based on eGFR < 60 mL/min/1.73m2. Those 1314 participants with successful analysis of ET-1 were further analyzed using binary logistic regression.
Results:
At follow-up, 47 (7.2%) men and 63 (9.6%) women had CKD stage 3 and above. The level of ET-1 was divided into quintiles showing that women in the highest quintile (n=132) had a significantly increased risk of developing CKD during the follow up period (OR=2.379, 95% CI:1.23-4.61, p<0.01) compared with the other quintiles (1-4), even when adjusted for age, physical activity, current smoking, alcohol consumption, hypertension, diabetes, BMI, high- sensitive CRP and LDL-cholesterol (OR=2.66, 95% CI:1.29-5.49, p<0.01). No significant differences were observed between quintiles of ET-1 and development of CKD in men (NS).
Conclusions:
High levels of ET-1 are associated with development of CKD in women but not in men.
Figure 1
Figure 2
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