The SARS-CoV-2 origin is linked to the acquisition by its closest progenitor of a positive insert in the spike glycoprotein. Itwas the PRRA polybasic motif atthe furin cleavage site. This furin recognition motif has no analogy with other B-lineage beta-coronaviruses, nor with the known Laos bat closest relatives. An hypothesis for probable PRRA human origin includes recombination between a SARS-CoV-2 progenitor genome and mRNA transcripts within human infected cells (previous study). However, whether during the pandemic PRRA-like insertions had occurred in the spike glycoprotein is unknown. Here I show a computational analysis of many large multiple sequence alignments involving 2,315,308SARS-CoV-2 spike glycoprotein sequences downloaded from NCBI Virus database (collection date January 2020 - April 2023). I found theN-terminal domain SRWM insert in 331 sequences from SARS-CoV-2clinical isolates with15 different submitters and organizations, lineages BE.1.1, BQ.1, BQ.1.28, FD.4; USA, 26 states, andcollection date November 2022 up to the analysis period. Both the SRWM S gene 12-nt coding insertand its reverse complement 100% matchedto several human mRNA RefSeq transcripts. The related genes were ubiquitous and highly expressed or specific of virustarget organs or tissues. I have also identified other 50 inserts of four amino acids or more in different structural domains of the protein fromdifferent SARS-CoV-2 clinical isolates. All with the similarcharacteristics. Inconclusion, these SARS-CoV-2 spike glycoprotein inserts seem not to be of viral origin. SARS-CoV-2 is a human virus. Human isthe host. The origin cannot be from another virus. It can be stated that a recombination between SARS-CoV-2 genome and human mRNA transcripts within infected cells would bethe origin of the inserts. The PRRA insert has the same features as those described here. This strongly support the hypothesis that the 12 nucleotides insert imprinted in the S gene encoding PRRA does not have a viral origin either, ratherhuman mRNA transcripts. In this case, SARS-CoV-2 must be changed by its closest ancestor. Viruses swap chunks of RNA through recombination: thus SARS-CoV-2 emerged - thus it also evolves.