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Protocol
Karina Berner
Stellenbosch University Faculty of Medicine and Health Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2255-371X
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
A fifth of adults in low-income and middle-income countries (LMICs) have multimorbid conditions, which are linked to socio-economic deprivation and aging. Multimorbidity is associated with high rates of functional problems and disability, increased healthcare utilization and lower quality of life. Literature on multimorbidity and associations with function is mostly from high-income countries (HICs) and focused among adults. Data regarding patterns and their impact on person-centered outcomes are limited. There is need for research into understanding common patterns of multimorbidity, and their association with functional impairment, particularly in LMICs. Therefore, the need for evidence-based, and context-relevant strategic policy, planning and delivery models for health and rehabilitation services is imperative in attaining Universal Health Coverage (UHC). The planned scoping review aims to provide an overview of the scope and nature of existing literature on multimorbidity patterns and function among adults in LMICs.
Methods
A scoping review will be conducted according to a five-step framework guidance. The PRISMA-ScR guidelines will be followed in reporting. A comprehensive electronic search of PubMed, Scopus, EBSCOhost (including MEDLINE and the Cumulative Index to Nursing and Allied Health Literature [CINAHL]), Scielo, Cochrane and Google Scholar will be conducted from January 1976 onwards. Studies will be included if they are primary or secondary, qualitative or quantitative research reported in English, published (between January 1976 and the search date) in a peer-reviewed journal, and describe multimorbidity patterns and associations with physical functional impairments, activity limitations or participation restrictions among adults in LMICs. Search results will be independently screened by two reviewers and data extraction will cover; study characteristics, participants’ characteristics, multimorbidity measures, patterns analysis and functional measures. Descriptive statistics and narrative synthesis will be used to synthesize and summarize the findings.
Discussion
Patients with multimorbidity have unique and cross-cutting needs, hence the need for an integrated and person-centered approaches to policy, planning and delivery of medical and rehabilitation services. Considering the shift towards primary healthcare-led management of chronic diseases and UHC, the proposed scoping review is timely and the findings will provide insights into the current extent and scope of multimorbidity research, and guide future inquiry in the field.
Protocol registration
Open Science Framework (OSF), osf.io/gcy7z
Keywords
Multimorbidity patterns, chronic diseases, functional impairment, activity limitation, participation restriction, physical function, low-resource settings, LMIC
This is a list of supplementary files associated with this preprint. Click to download.
- Additionalfile1Glossaryofkeyterms1.docx
Title of data: Glossary of key terms relevant to the scoping review protocol Description of data: A list of definitions of important concepts referred to in the main manuscript.
- AdditionalFile2PRISMAPchecklist08March2021.docx
Title of data: PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) 2015 checklist Description of data: Completed PRISMA-P Checklist for the review protocol, indicating (where applicable at the stage of a protocol) where relevant sections are addressed.
- Additionalfile3Keywordsclean1.docx
Title of data: Proposed keywords to be used in the search syntax. Description of data: A list of proposed keywords for the pilot PubMed-based search strategy, including a list of low-income and middle-income countries as classified by the World Bank.
- CopyofAdditionalfile4Pilotdataextractionform1.xlsx
Title of data: Pilot data extraction form. Description of data: Pilot data extraction categories developed for the scoping review.
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Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 16 Mar, 2021
No community comments so far
Reviews received
Received 30 Jan, 2022
Reviewers invited
Invitations sent on 20 Jan, 2022
Editor assigned
On 11 Oct, 2021
Editor invited
On 10 Oct, 2021
Submission checks complete
On 14 Mar, 2021
First submitted
On 09 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Health Economics & Outcomes Research
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A new preprint design is coming!
We have improved readability, clarity, accessibility, and opportunities for engagement.
This preprint is under consideration at Systematic Reviews. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Protocol
Karina Berner
Stellenbosch University Faculty of Medicine and Health Sciences
Corresponding Author
ORCiD: https://orcid.org/0000-0002-2255-371X
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 16 Mar, 2021
No community comments so far
Reviews received
Received 30 Jan, 2022
Reviewers invited
Invitations sent on 20 Jan, 2022
Editor assigned
On 11 Oct, 2021
Editor invited
On 10 Oct, 2021
Submission checks complete
On 14 Mar, 2021
First submitted
On 09 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Health Economics & Outcomes Research
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background
A fifth of adults in low-income and middle-income countries (LMICs) have multimorbid conditions, which are linked to socio-economic deprivation and aging. Multimorbidity is associated with high rates of functional problems and disability, increased healthcare utilization and lower quality of life. Literature on multimorbidity and associations with function is mostly from high-income countries (HICs) and focused among adults. Data regarding patterns and their impact on person-centered outcomes are limited. There is need for research into understanding common patterns of multimorbidity, and their association with functional impairment, particularly in LMICs. Therefore, the need for evidence-based, and context-relevant strategic policy, planning and delivery models for health and rehabilitation services is imperative in attaining Universal Health Coverage (UHC). The planned scoping review aims to provide an overview of the scope and nature of existing literature on multimorbidity patterns and function among adults in LMICs.
Methods
A scoping review will be conducted according to a five-step framework guidance. The PRISMA-ScR guidelines will be followed in reporting. A comprehensive electronic search of PubMed, Scopus, EBSCOhost (including MEDLINE and the Cumulative Index to Nursing and Allied Health Literature [CINAHL]), Scielo, Cochrane and Google Scholar will be conducted from January 1976 onwards. Studies will be included if they are primary or secondary, qualitative or quantitative research reported in English, published (between January 1976 and the search date) in a peer-reviewed journal, and describe multimorbidity patterns and associations with physical functional impairments, activity limitations or participation restrictions among adults in LMICs. Search results will be independently screened by two reviewers and data extraction will cover; study characteristics, participants’ characteristics, multimorbidity measures, patterns analysis and functional measures. Descriptive statistics and narrative synthesis will be used to synthesize and summarize the findings.
Discussion
Patients with multimorbidity have unique and cross-cutting needs, hence the need for an integrated and person-centered approaches to policy, planning and delivery of medical and rehabilitation services. Considering the shift towards primary healthcare-led management of chronic diseases and UHC, the proposed scoping review is timely and the findings will provide insights into the current extent and scope of multimorbidity research, and guide future inquiry in the field.
Protocol registration
Open Science Framework (OSF), osf.io/gcy7z
This is a list of supplementary files associated with this preprint. Click to download.
- Additionalfile1Glossaryofkeyterms1.docx
Title of data: Glossary of key terms relevant to the scoping review protocol Description of data: A list of definitions of important concepts referred to in the main manuscript.
- AdditionalFile2PRISMAPchecklist08March2021.docx
Title of data: PRISMA-P (Preferred Reporting Items for Systematic review and Meta-Analysis Protocols) 2015 checklist Description of data: Completed PRISMA-P Checklist for the review protocol, indicating (where applicable at the stage of a protocol) where relevant sections are addressed.
- Additionalfile3Keywordsclean1.docx
Title of data: Proposed keywords to be used in the search syntax. Description of data: A list of proposed keywords for the pilot PubMed-based search strategy, including a list of low-income and middle-income countries as classified by the World Bank.
- CopyofAdditionalfile4Pilotdataextractionform1.xlsx
Title of data: Pilot data extraction form. Description of data: Pilot data extraction categories developed for the scoping review.
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