The term menopause (from Greek: men - month, pausis - termination), denotes the end of ovulation cycles, 1 occurs in women between 45 and 50 years of age, and denotes the persistent absence of menstruation for more than a year, caused by a permanent ovarian insufficiency. Menopause is associated with the gradual, irreversible cessation of hormonal functions of the ovaries following the disappearance of the hormonal interaction system between the hypothalamus, pituitary and ovaries. The age at which menopause occurs is to a large extent genetically determined. A significant increase in gonadotropins concentration and a decrease in estrogen concentration occur, along with a sensation of heat, paroxysmal facial flushing, mood and sleep disorders, depression, and atrophic changes in estrogen-dependent tissues. 2 Menopause is divided into: premenopause (around the age of 40), when an increase in the concentration of gonadotropic hormone in the serum, perimenopause (decrease in estrogen and progesterone levels), proper menopause and after menopause. This process is a consequence of a disruption in the feedback on the hypothalamic-pituitary-ovarian axis. At this stage, progesterone and estrogen concentrations are low, whereas as a result of peripheral aromatization of androstenedione, estrone concentrations increase and estradiol concentrations decrease. Thus, although the ovaries are capable of producing androstenedione, its synthesis is lower compared to the premenopausal period. Additionally, in the peri-menopausal period, the concentration of dehydroepiandrostendione decreases. 3 Menopause, as well as perimenopause represent periods in women’s life which involve changes to the skin. Due to aging and hypoestrogenism, this organ is subject to structural changes, as estrogen plays a key role in collagen growth and skin hydration. Lower levels of 17-β estradiol negatively impact its protective function in both keratinocytes and fibroblasts, which coupled with oxidative stress, result in dry skin. The observed changes include loss of collagen, elastin, fibroblast function and vascularization. The spontaneous reaction of non-enzymatic attachment of hexoses to the free amino groups of collagen proteins results in shortening, disorganization of collagen fibers, and consequently a decrease in viscoelastic properties of tissues and loss of skin elasticity. Decreased estrogen levels increase the enzymatic activity of matrix metalloproteinases, causing degradation of extracellular matrix (ECM) proteins, i.e. collagen, laminin, proteoglycans and fibronectin. 4,5,6 At the cellular level, keratinocyte proliferation is impaired, atrophic processes dominate over regeneration, and degenerative changes are exacerbated. Paroxysmal erythema of the face, neck and décolleté appears, along with a reduction of adipose tissue, excessive keratinization of the epidermis, hirsutism and diffuse, frontal and scarring alopecia. The aforementioned ailments are also accompanied by diaphoresis, hot flushes, tachycardia and anxiety. During menopause, the impact of hypoestrogenism on the skin is manifested by a decrease in the hydroxyproline content of type I collagen, as well as in the number of immature cross-links, and highly hygroscopic glycosaminoglycans, which results in poorer skin hydration. Furthermore, a decreased adhesion of the stratum corneum cells and a flattening of the epidermal-dermal boundary is observed, along with an impaired exchange of nutrients and metabolites between the epidermis and dermis. 7As a hormone-dependent organ, the skin is affected by sex hormones, mediated by receptors. The greatest accumulation of receptors is found in the estrogen-dependent areas (i.e., face, genitals, lower limbs), whereas the fewest are found in the brain tissue, mammary glands, bones, as well as in the cardiovascular and genitourinary system. 8 Estrogens are formed in the pathway of synthesis, an enzyme-catalyzed reaction of androgen aromatization, in the organs of the reproductive system. Moreover, the extra-genital tissues possessing the ability to aromatize androgens to estrogens also constitute an additional source of hormones. Estrogens include estrone, estradiol, and estriol, 9 with estradiol representing the most active estrogen, while estrone and estriol are weak. 10 One of the non-invasive treatments enhancing women’s self-esteem is mono-, or bipolar radiofrequency. The method improves the skin tone by remodeling it via the process of neocollagenesis and elastogenesis following deep volumetric heating. The energy emitted generates thermal energy which results in conformational changes, without causing ablation. 11