Patients
The clinical characteristics of patients in the MSD-HSCT and haplo-HSCT groups are summarized in table 1 and table 2. No significant difference was observed between the PTCY groups and the control groups in terms of baseline demographics except for stem cell source. Eight patients (40%) of MSD-control group and all patients of haplo-control group received PBSCs and BM, while all patients of PTCY groups received PBSCs and UC-MSCs, except for two patients who suffered from primary graft failure received extra BM from a secondary donor in the haplo-PTCY group. There were 6 males (46.2%) and 13 males (59.1%) in the MSD-PTCY and haplo-PTCY groups and the median ages were 20 (range 9 to 35) and 14 (range 3 to 31) years respectively. One patient of each PTCY group was treated with anti-human lymphocyte immunoglobulin pretransplantation. The remaining patients had previously received treatment with CSA and/or steroids. In addition, two patients (9.1%) had hospital admissions for pulmonary infection requiring treatments prior to admission in the haplo-PTCY group, and one of the two patients had additional fungal sinus infections. Fortunately, the infections of the two patients were controlled after engraftment.
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)
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)
Engraftment
In the MSD-PTCY group, all patients successfully engrafted. The median numbers of infused MNCs and CD34+ cells between the MSD-PTCY and control groups were similar (MNCs: 16.36 (range 12.57 to 23.91) x108/kg vs 14.04 (range 6.33 to 24.95) x108/kg; CD34+ cells: 7.39 (range 4.35 to 18.4) x106/kg vs 5.39 (range 1.02 to 13.37) x106/kg). However, We observed that the times to neutrophil and platelet engraftment were shorter in the MSD-PTCY group than in the control group (11 days (range 10 to 14) vs 13 days (range 10 to 23) and 12 days (range 9 to 15) vs 14 days (range 10 to 45)). The difference in graft rejection between the MSD-PTCY and control groups was not significant(7.7% vs 15.0%). The rates of chimerism at day +30 in the MSD-PTCY and control groups were 100% and 90% respectively, and there was no significant difference.
In the haplo-HSCT groups, the median numbers of infused MNCs and CD34+ cells between the haplo-PTCY and control groups were similar (MNCs: 18.73 (8.41-32.35) x108/kg vs 23.43 (2.02-31.72) x108/kg; CD34+ cells: 7.60 (4.21-19.45) x106/kg vs 8.95 (1.76-22.53) x106/kg). Two patients who suffered from primary graft failure experienced successful engraftment after receiving transplants from haploidentical donors in the haplo-PTCY group. In the haplo-control group, secondary graft failure developed in one patient at 1.5 months after transplantation, and this patient sustained engraftment after undergoing MMUD-HSCT. The times to neutrophil and platelet engraftment were shorter in the haplo-PTCY group than in the control group (12 days (range 9 to 15) vs 13 days (range 11 to 19) and 11.5 days (range 9 to 17) vs 14 days (range 11 to 62)). One patient from each group suffered graft rejection.
Acute and chronic GVHD
The cumulative incidence of aGVHD at day +100 in the MSD-PTCY group was 15.4% (95% CI: 2.2-39.9) compared to 50.0% (95% CI: 26.3-69.8) in the control group (P=0.050) (Fig. 1a). The cumulative incidence of grade II-IV aGVHD in the MSD-PTCY group was lower than that in the control group, 7.7% (95% CI: 0.4-30.3) vs 30.0% (95% CI: 11.8-50.7), but the difference did not reach statistical significance (P=0.122) (Table 3). No patient developed cGVHD in the MSD-PTCY group. In contrast, the 1-year cumulative incidence of cGVHD in the control group was 15.0% (95% CI: 3.5-34.1)(Fig. 1b).
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)
The cumulative incidence of aGVHD at day +100 in the haplo-PTCY group was lower than that in the control group(Table 4), 31.8% (95% CI: 13.8-51.6) vs 60.0% (95% CI: 29.9-80.6), but we observed no significant difference (P=0.165) (Fig. 2a). The cumulative incidences of grade II-IV aGVHD in the haplo-PTCY group was 27.3% (95% CI: 10.8-46.9) compared to 53.3% (95% CI: 24.8-75.3) in the control group(P=0.170). Notably, one patient with grade IV liver aGVHD had intracranial aGVHD, and one patient with aGVHD developed skin cGVHD in the haplo-PTCY group. The 1-year cumulative incidence of cGVHD in the haplo-PTCY and the haplo-control groups was no difference(P=0.600), 18.2% (95% CI: 5.5-36.8) vs 26.7% (95% CI: 7.7-50.7) (Fig. 2b). There was no extensive cGVHD in the haplo-PTCY group, while one patient developed extensive cGVHD in the control group.
![](data:image/png;base64,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)
Regimen-Related Toxicities
The incidence of pulmonary infection in the MSD-PTCY group was obviously lower than that in the control group (P=0.022), 7.7% vs 50.0%. Similarly, the incidences of CMV and EBV reactivation in the MSD-PTCY group were significantly lower than those in the control group (CMV: 23.1% vs 65.0%; EBV: 0 vs 60.0%), and there were significant differences between the two groups (P: 0.032 and 0.001, respectively). Although the incidence of hemorrhagic cystitis was lower in the MSD-PTCY group than in the control group (7.7% vs 35.0%), the difference was not significant (P=0.108). One patient suffered from pure red cell aplasia (PRCA) after ABO-compatible HSCT, and hematopoietic recovery occurred eighteen months after transplantation. In the control group, four of twelve patients with EBV reactivation developed posttransplantation lymphoproliferative disorders (PTLD) and three patients were cured through combination therapy with immunosuppressor withdrawal, rituximab and donor lymphocyte infusion (DLI). Another patient experienced an epileptic seizure because of intracranial EBV infection. Furthermore, two patients developed unexplained seizures that were relieved after expectant treatment. Cardiotoxicity and thrombotic microangiopathy (TMA) each developed in one patient. No patient had veno-occlusive disease (VOD).
The incidence of pulmonary infection in the haplo-PTCY group was lower than that in the control group (40.1% vs 60.0%), while the incidence of CMV reactivation in the haplo-HSCT group was higher than that in the control group (81.8% vs 53.3%), but the differences were not statistically significant (P: 0.325, 0.080). The median times to CMV infection were +37 days (range 29 to 46) and +35 days (range 25 to 53) in the haplo-HSCT and the control groups respectively. Two of eighteen patients with CMV infection in the haplo-HSCT group and one of eight patients with CMV infection in the control group developed cytomegalovirus retinitis. The incidence of EBV reactivation in the haplo-HSCT group (22.7%) was obviously lower than that in the control group (80.0%), and the difference was significant (P=0.001). There were no PTLD in the haplo-PTCY group, but three patients developed PTLD based on their seropositive EBV status in the control group. The incidences of hemorrhagic cystitis with BKV seropositivity were similar between the haplo-HSCT group and the control group (31.8% and 26.7%). In the haplo-PTCY group, one of seven patients who were seropositive for BKV progressed to BKV encephalitis and suffered from intracranial fungal infection. In addition, one patient had TMA at day +50. Moreover, posterior reversible encephalopathy syndrome (PRES) developed in four patients in the haplo-PTCY group and in two patients in the control group. None of all patients developed VOD in the two groups.
Survival
The median follow-up time of the MSD-PTCY group was similar to that in the control group, 22 months (range 10 to 36) vs 21.5 months (range 2 to 36). The median follow-up of the haplo-HSCT and the control groups were 11.5 months (range 3 to 27) and 12 months (range 1.5 to 36), respevtively.
All thirteen (100%) patients in the MSD-PTCY group are now alive with normal hematopoiesis. Interestingly, one female is now three months pregnant. The 1-year OS of the MSD-PTCY group was 100% compared to 75.0% (95% CI: 50.0-88.7)% in the MSD-control group (P=0.057) (Fig. 3a). The 1-year EFS of the MSD-PTCY group was 92.3% (95% CI: 56.6-98.9)% compared to 65.0% (95% CI: 40.3-81.5)% in the MSD-control group (P=0.071) (Fig. 3b). In the control group, three patients died from serious pulmonary infection at 2, 3 and 5 months, one patient died of intracranial EBV infection at day +70, and one patient died of TMA at 4 months. In the MSD-PTCY group, twelve of thirteen patients had a follow-up period of more than 12 months at the time of writing. All the patients began to reduce immunosuppressor treatment at 6 months and these agents were withdrawn before 9 months except for the patient with PRCA.
In the haplo-PTCY group, two patients died from intractable pulmonary infection at 3 and 9 months, one patient died of cerebral hemorrhage at 3 months, and one patient died of intestinal GVHD at 7 months. In the control group, two patients died from pulmonary infection at 4 and 6 months, and one patient died of severe intestinal GVHD at 12 months. The cumulative incidence of 1-year OS was 81.8% (95% CI: 58.5-92.8) in the haplo-PTCY group compared to 77.1% (95% CI: 44.2-92.1) in the haplo-control group (Fig. 4a). The 1-year EFS in the haplo-PTCY group vs the control group was 66.9% (95% CI: 39.1-84.2) vs 40.8% (95% CI: 20.5-71.2) (Fig. 4b). However, there was no significant difference in 1-year OS or EFS between the groups. In the haplo-PTCY group, eleven of eighteen living patients had a follow-up period of more than 12 months at the time of writing, those patients began to reduce immunosuppressor treatment at 9 months after HSCT.