A sudden surge in malaria cases was observed in the district of Riaba, Bioko Island, at the start of 2019. Between January and April, confirmed malaria cases and malaria incidence increased about three-fold compared to the same period in 2018. Concurrently, anopheline human biting rate (HBR) increased 2.1-fold. During the outbreak, 82.2% of the district population was tested for malaria with a rapid diagnostic test and 37.2% were found positive and treated according to national guidelines. Vector control interventions, including indoor residual spraying and larval source management were scaled-up in response. After the interventions, the number of confirmed cases decreased by 70% and the overall parasite prevalence in the communities by 43.8%. Observed prevalence in a follow up malaria indicator survey, however, was significantly higher than elsewhere on the island and higher than in previous years. There was no significant reduction in HBR, which remained high for the rest of the year. The surge was attributed to various factors, chiefly increased rainfall and a large number of anthropogenic anopheline breeding sites created by construction works. This case study illustrates the need for sustained vector control interventions and multi-sector participation, particularly in malaria control settings with persistently high receptivity to local transmission.