Biopolymers are naturally occurring molecules and are also found in form of a chemical block of long length. The primary components of raw materials are presented by biopolymers which are used to produce food such as proteins, lipids, starch, and fiber. The alterations of biopolymers occurred during the processing of food, thus affecting the quality of food (Pilli & Alessandrino, 2020). Hence, various kinds of physical forces appeared during processing and affected biopolymer modifications on microscopic, nanoscopic and molecular scales (Paulik, Jekle, & Becker, 2019). Natural and artificial biopolymers are making their way in many fields like science, bio-interface engineering, tissue engineering, drug delivery and material science. In the market, attention is also paid towards synthetic-based biopolymers as a new class of materials. The basic purpose is to give an initial step based on design parameters techniques, and characterization methodologies for biopolymers. In 2019, the most critical issue of biopolymers i-e biodegradability was irrespective of many useful aspects in the synthetic and protein industry. Nowadays, natural biopolymers are replacing them due to their unique properties of biodegradability and eco-friendly. Peptide-based biopolymers have great applications in protein purification and also many other useful applications. The peptide-based materials are very biocompatible. The peptides and protein drugs are very immunogenic and it is very important to consider their immunogenicity. In the recent era, carbohydrate based polymers are considered to be the replacement. Cellulose, collagen, hyaluronic acid, and fibrin gels are examples of natural biopolymers. Cellulose is biodegradable as well as biorenewable and a stiff material having a very low specific weight. It is foreseen to be an excellent replacement for synthetic materials as well as protein based polymers. Biotechnology is very useful for the modification of the polymer structure for achieving the desirable characteristics. The inborn OH functionality of cellulose is very interesting property that render cellulose a very promising material for utilization in any way, such as chromatography and protein purification. Proteins are considered an important food component and also play an important role in the structural and functional development of living organisms (Zhou, et al., 2018). Proteins have a not only critical role in human lives but also have a significant place in the food and pharmaceutical industries (Fu, et al., 2018). The protein has many good attributes for industrial applications (Rashid, Hussain, & ZaheerAhmed, 2018). In the study and analysis processes of proteins, the most important aspect is to evaluate the purification of protein. Purification is the most fundamental step as many diseases are associated with protein malfunction. There are many kinds of purification strategies based on the desired scale, throughput, and various applications (MagneGST, 2022). Kasuri Methi was utilized for the isolation and purification of galactomannan from local fenugreek is a water-soluble heteropolysaccharide. Recently nanoparticles have been introduced for the distillation of proteins (Zhou, et al., 2018). The separation, modification, and disinfection have now become necessary Traditional particle gel packed column is used nowadays for protein purification. By now, several membrane chromatographic materials including inorganic fibrous adsorbents, natural polymeric adsorbents, and synthetic polymeric adsorbents have been introduced. The electro spinning technique is a very effective method to assemble nanofibrous chromatographic materials with fast adsorption equilibrium, low pressure, high adsorption capacity, and high solution throughput (Fu, et al., 2018). However, there are many limitations concerning this procedure. Therefore, different low-pressure chromatographic materials with high adsorption rates and capacity are needed. Numerous research have been performed on exploring chromatographic materials with low-pressure qualities (Fu, et al.,2018). The scientists are still trying to improve the material in the sense of the cost of the material itself and the binding capacities. We have the contribution in the downstream processing and various materials were synthesized having high binding capacities (Bibi et al. 2011, Bibi et al. 2012, Bibi et al. 2012, Bibi et al. 2013, Naveen et. al. 2015 and Poondi et. al. 2015). To put our efforts in this stream, it is planned that a new material would be synthesized for the downstream processing of proteins, which is believed to have the ability to integrate few steps and would be a comparatively economical source. The locally available material, polyester and cellulosic will be chemically modified to cation exchanger in the first step to see the viability of the idea.