Objective: Glioma is the most common primary intracranial tumor. The proteins encoded by the Chromobox (CBX) family genes are essential components of the epigenetic regulatory complexes, which have been proved to be related to tumor progression in many cancers. However, little is known about the expression and prognostic value of CBX in human glioma.
Methods: The transcription and survival data of CBXs in glioma patients were explored from the online databases: Oncomine, Gene Expression Profiling Interactive Analysis (GEPIA), Chinese Glioma Genome Atlas (CGGA), GeneMANIA, DAVID, cBioPortal and TIMER.
Results: The expression levels of CBX3, CBX6, CBX7, and CBX8 were significantly related to glioma classification. CBX4 was significantly associated with glioma recurrence. Survival analysis showed that the expression levels of CBX3, CBX6, CBX7 and CBX8 were significantly related to the prognosis of patients. Moreover, the expression levels of CBXs were related to the infiltration of neutrophils, macrophages, B cells, CD4 + T cells, CD8 + T cells and dendritic cells (DCs) in glioma tissues.
Conclusions: Our study showed that CBXs were significantly related to the progression, recurrence, prognosis and immune status of glioma. It indicated that CBXs may become a potential insight for epigenetic therapy, immunotherapy, and precision therapy of glioma.