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Research note
IBE MICHAEL USMAN
Kampala International University - Western Campus
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6624-1286
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective:
This was to determine levels of heavy metal expression following Tamarindus indica activity in neonatal rats. Pregnant timed rats were divided into 5 groups (n =4) and neonatal rats were used. Group 1 (negative control), Groups II-V were experimental groups treated with 100 mg/kg of AlCl3 s/c. Group II (positive control), Groups III and IV receiving 400mg/kg and 800mg/kg of Tamarindus indica respectively, and Group 5 receiving 30mg/kg of Vitamin E (comparative control) for 3 weeks. Brain metal; copper, zinc, iron, and calcium (Cu, Zn, Fe, and Ca respectively) quantification was done using atomic absorption spectrophotometer.
Results:
Tamarindus indica contained 61.6% Oleic Acid, n-Hexadecanoic acid 11.03%, Phenol, 3,5-bis (1,1-dimethyl ethyl)- 8.48 %, and cis-9-Hexadecenal 7.79% as the main components in Tamarindus indica. The differential expression of brain metals in the treatment groups on post gestation day 7 and 21 revealed significantly high mean Zn, Fe, and Cu and lower Ca expression in the positive control compared to the negative control; but significantly lower mean Zn, Fe, and Cu and higher Ca expression was observed in the group treated with 400 and 800mg/kg bw of EATI and comparative control when compared to values observed in positive control.
Keywords
Tamarindus indica, Phytochemical, Brain metals, Neurochemicals, Aluminum toxicity, Aluminum chloride
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CURRENT STATUS: Under Review
Version 1
Posted 22 Mar, 2021
No community comments so far
Review #2 received
Received 30 Mar, 2021
Reviewer #2 agreed
On 13 Mar, 2021
Reviewer #1 agreed
On 11 Mar, 2021
Reviewers invited
Invitations sent on 09 Mar, 2021
Editor assigned
On 08 Mar, 2021
Submission checks complete
On 08 Mar, 2021
Editor invited
On 08 Mar, 2021
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Subject Areas
Toxicology
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This preprint is under consideration at BMC Research Notes. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research note
IBE MICHAEL USMAN
Kampala International University - Western Campus
Corresponding Author
ORCiD: https://orcid.org/0000-0001-6624-1286
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 1
Posted 22 Mar, 2021
No community comments so far
Review #2 received
Received 30 Mar, 2021
Reviewer #2 agreed
On 13 Mar, 2021
Reviewer #1 agreed
On 11 Mar, 2021
Reviewers invited
Invitations sent on 09 Mar, 2021
Editor assigned
On 08 Mar, 2021
Submission checks complete
On 08 Mar, 2021
Editor invited
On 08 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Toxicology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Objective:
This was to determine levels of heavy metal expression following Tamarindus indica activity in neonatal rats. Pregnant timed rats were divided into 5 groups (n =4) and neonatal rats were used. Group 1 (negative control), Groups II-V were experimental groups treated with 100 mg/kg of AlCl3 s/c. Group II (positive control), Groups III and IV receiving 400mg/kg and 800mg/kg of Tamarindus indica respectively, and Group 5 receiving 30mg/kg of Vitamin E (comparative control) for 3 weeks. Brain metal; copper, zinc, iron, and calcium (Cu, Zn, Fe, and Ca respectively) quantification was done using atomic absorption spectrophotometer.
Results:
Tamarindus indica contained 61.6% Oleic Acid, n-Hexadecanoic acid 11.03%, Phenol, 3,5-bis (1,1-dimethyl ethyl)- 8.48 %, and cis-9-Hexadecenal 7.79% as the main components in Tamarindus indica. The differential expression of brain metals in the treatment groups on post gestation day 7 and 21 revealed significantly high mean Zn, Fe, and Cu and lower Ca expression in the positive control compared to the negative control; but significantly lower mean Zn, Fe, and Cu and higher Ca expression was observed in the group treated with 400 and 800mg/kg bw of EATI and comparative control when compared to values observed in positive control.
Figure 1
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