Chung et al30. (2021)
|
RCT. Single-center
|
I - III
|
16
|
13
|
T 52.4 ± 8.9
C: 50.3 ± 7.7
|
AC
|
Aerobic exercise modality: Continuous. Time: 40 min/ sessions. Frequency: 2–3 sessions /w. Duration: 3m. Intensity:70–75% VO2max.
|
Linear
|
⑤㉒
|
De Luca et al31. (2016)
|
RCT. Single-center
|
I - III
|
10
|
10
|
T: 50.2 ± 9.7
C:46.0 ± 2.8
|
Chemotherapy, radiation, hormonal therapy
|
Aerobic exercise modality: Continuous. Time: 30 min/ sessions. Frequency: 2 sessions /w. Duration: 24w. Intensity:70–75% HR max.
|
Linear
|
⑤⑫
|
Lee et al32. (2020)
|
RCT. Single-center
|
0 to 3
|
48
|
45
|
T: 52.8 ± 10.6
C: 53.6 ± 10.1
|
Chemotherapy
|
Aerobic exercise modality: Continuous. Time: 5 minutes every 3–4 weeks resulting in a total of 45 minutes per session by week 16. Frequency: 3 sessions /w. Duration: 16w. Intensity:65–80% HR max.
|
Nonlinear
|
⑦⑱⑳㉑
|
Hornsby et al33. (2013)
|
RCT. Single-center
|
IIB - IIIC
|
10
|
10
|
T: 51 ± 6
C: 46 ± 11
|
AC, neoadjuvant chemotherapy
|
Aerobic exercise modality: Continuous & Interval. Time:1st w: 15–20 min/ sessions. 2nd -4th w: 30min/ sessions.5th -6th w: 30-45min/sessions. 7th -9th w: 20min/ sessions. 10th -12th w: 20min / sessions. Frequency: 3 sessions /w. Duration: 12w. Intensity: 1st – 4th w: 60% VO2max. 5th -6th w: 60–65% VO2max; 7th -9th w: 60–70% VO2max; 10th -12th w: 60–70%VO2max& 100%VO2max
|
Nonlinear
|
⑤㉒
|
Dieli-Conwright et al34. (2018)
|
RCT. Single-center
|
I - III
|
48
|
45
|
T: 52.8 ± 10.6
C: 53.6 ± 10.1
|
Chemotherapy, radiotherapy
|
Aerobic exercise modality: Continuous. Time: 5 minutes every 3–4 weeks resulting in a total of 45 minutes per session by week 16. Frequency: 3 sessions /w. Duration: 16w. Intensity: 65–80% HR max.
|
Nonlinear
|
⑥⑧⑩⑪⑫⑬⑭
|
Dieli-Conwright et al35. (2018)
|
RCT. Single-center
|
I - III
|
48
|
45
|
T: 52.8 ± 10.6
C: 53.6 ± 10.1
|
Chemotherapy, radiotherapy
|
Aerobic exercise modality: Continuous. Time: 5 minutes every 3–4 weeks resulting in a total of 45 minutes per session by week 16. Frequency: 3 sessions /w. Duration: 16w. Intensity: 65–80% HR max.
|
Nonlinear
|
⑤
|
Lee et al36. (2019)
|
RCT. Single-center
|
I - III
|
48
|
45
|
T: 52.8 ± 10.6
C: 53.6 ± 10.1
|
Chemotherapy, radiotherapy
|
Aerobic exercise modality: Continuous. Time: 5 minutes every 3–4 weeks resulting in a total of 45 minutes per session by week 16. Frequency: 3 sessions /w. Duration: 16w. Intensity: 65–80% HR max.
|
Nonlinear
|
⑨⑲
|
Cornette et al37. (2016)
|
RCT. Single-center
|
I - IIIB
|
20
|
22
|
T: 49
C: 52
|
3 FEC100, 3
|
Aerobic exercise modality: Continuous. Time: Start with 20 minutes, increase by 5 minutes per 6 weeks. Frequency: 3 sessions /w. Duration: 27w. Intensity: 18 ± 2 maximum rated perceived exertion.
|
Nonlinear
|
⑤
|
Ochi et al38. (2022)
|
RCT. Single-center
|
early-stage
|
21
|
23
|
|
Hormone therapy
|
Aerobic exercise modality: High Intensity Aerobic Interval. Time: NA. Frequency: 3 sessions /w. Duration: 12w. Intensity: Maximum rated perceived exertion 18 ± 2.
|
Linear
|
⑤
|
Courneya et al39. (2003)
|
RCT. Single-center
|
I - IIIA
|
24
|
28
|
T: 59 ± 5
C: 58 ± 6
|
|
Aerobic exercise modality: Continuous. Time: Start with 15 minutes and increase by 5 minutes every 3 weeks. Frequency: 3 sessions /w. Duration: 15w. Intensity: 70%-75% VO2max.
|
Nonlinear
|
⑤⑥ ⑩
|
Scott et al25. (a) (2019)
|
RCT. Single-center
|
I - III
|
58
|
57
|
T: 59 ± 9
C: 58 ± 9
|
Surgery, chemotherapy, radiotherapy, endocrine therapy
|
Aerobic exercise modality: Continuous. Time:1st -4th w:30–40 min; 5th -16th w: 40. Frequency: 1st – 3rd w: 3 sessions /w; 4th -16th w: 4 sessions /w. Duration: 16w. Intensity: 1st – 3rd w: 55%-60% VO2max, 4th -16th w: 60% − 70% VO2max.
|
Linear
|
⑤
|
Scott et al25. (b) (2019)
|
RCT. Single-center
|
I - III
|
59
|
57
|
T: 58 ± 9
C: 58 ± 9
|
Surgery, chemotherapy, radiotherapy, endocrine therapy
|
Aerobic exercise modality: Interval. Time: 120 min/week. Duration: 16w. Intensity: alternated between five different dose intensities (55%, 65%, 75%, 80%, and > 95%) of VO2max
|
Nonlinear
|
⑤
|
Vincent et al40. (2019)
|
RCT. Single-center
|
I - III
|
55
|
26
|
-
|
FEC & TZB & TAX
|
Aerobic exercise modality: Continuous. Time: 30 min/week. Frequency: 2 sessions /w. Duration: 6m. Intensity: 60% − 70% VO2peak
|
Linear
|
⑤⑥⑪
|
Hojan et al41. (2020)
|
RCT. Single-center
|
IB - IIIA
|
26
|
21
|
T: 54.44 ± 6.29
C: 54.64 ± 5.26
|
TZB
|
Aerobic exercise modality: Continuous. Time: 45–50 min/week. Frequency: 5 sessions /w. Duration: 9w. Intensity: 80% HR max
|
Linear
|
㉑㉒
|
Murtezani et al42. (2014)
|
RCT. Single-center
|
I - IIIA
|
30
|
32
|
T: 53 ± 11
C: 51 ± 11
|
Surgery
|
Aerobic exercise modality: Continuous. Time: Start with 15 minutes, increase by 2 minutes per week. Frequency: 3 sessions /w. Duration: 10 w. Intensity: 50% -75%HRR
|
Nonlinear
|
⑥⑩
|
Lee et al36. (2019)
|
RCT. Single-center
|
I - III
|
15
|
15
|
T: 47.1 ± 7.9
C: 44.7 ± 11.2
|
AC
|
Aerobic exercise modality: High Intensity Aerobic Interval. Time: 20 minutes. Frequency: 3 sessions /w. Duration: 8 w. Intensity: 7 times of a 1- min interval performed at 90% PPO; followed by a 2 – min interval performed at 10% PPO
|
Linear
|
⑤
|
Courneya et al43. (2007)
|
RCT. Single-center
|
I - IIIA
|
71
|
73
|
T: 49
C: 49
|
AC & TAX & FEC100C, CE120F
|
Aerobic exercise modality: Continuous. Time: Start with 15 minutes and increase by 5 minutes every 3 weeks. Frequency: 3 sessions /w. Duration: 8 w. Intensity: 60% -80% VO2max
|
Nonlinear
|
⑤⑩⑪ ⑫⑬
|
Jones et al44. (2013)
|
RCT. Single-center
|
IIB - IIIC
|
10
|
10
|
T: 51 ± 6
C: 46 ± 11
|
AC
|
Aerobic exercise modality: Continuous & Interva. Time: 1st w: 15–20 min/ sessions. 2nd -4th w: 30min/ sessions. 5th -6th w: 30-45min/ sessions. 7th -9th w: 20min/ sessions. 10th -12th w: 20min / sessions. Frequency: 3 sessions /w. Duration: 12 w. Intensity: 1st – 4th w: 60% VO2max. 5th -6th w: 60–65%VO2max. 7th -9th w: 60–70%VO2amx. 10th -12th w: 60–70%VO2max & 100%VO2max
|
Nonlinear
|
⑤
|
Irwin et al45. (2009)
|
RCT. Single-center
|
I - IIIA
|
37
|
38
|
T: 56.5 ± 9.5
C: 55.1 ± 7.7
|
Radiation and chemotherapy
|
Aerobic exercise modality: Continuous. Time: 15–30 min/ sessions. Frequency: 3 sessions /w. Duration: 6m. Intensity: 50% increased to 60–80% HRmax
|
Nonlinear
|
⑥⑩⑫⑬⑭⑮
|
Northey et al26. (a) (2019)
|
RCT. Single-center
|
I - III
|
5
|
6
|
T: 67.8 ± 7.0
C: 61.5 ± 7.8
|
Surgery, chemotherapy, radiation. Aromatase inhibitor
|
Aerobic exercise modality: Continuous. Time: 20 min/ sessions. Frequency: 3 sessions /w. Duration: 12w. Intensity: 55–65%VO2max
|
Linear
|
⑤
|
Northey et al26. (b) (2019)
|
RCT. Single-center
|
I - III
|
6
|
6
|
T: 60.3 ± 8.1
C: 61.5 ± 7.8
|
Surgery. Radiation. Aromatase inhibitor
|
Aerobic exercise modality: High Intensity Aerobic Interval. Time: 20 min/ sessions. Frequency: 3 sessions /w. Duration: 12w. Intensity: 4 intervals in 1st w, increased by one each week until the target of 7 intervals was achieved in 4th w 50–90% VO2max.
|
Nonlinear
|
⑤
|
Fairey et al46. (2005)
|
RCT. Single-center
|
I - IIIA
|
24
|
28
|
T: 59 ± 5
C: 58 ± 6
|
Surgery, radiation, chemotherapy
|
Aerobic exercise modality: Continuous. Time: 15min for weeks 1 through 3, and then systematically increased by 5min every three weeks thereafter to 35 min for weeks 13 through 15. Frequency: 3 sessions /w. Duration: 15w. Intensity: 70–75% VO2max
|
Nonlinear
|
⑰⑱⑲⑳㉑
|
Irwin et al47. (2015)
|
RCT. Single-center
|
0 - III .
|
45
|
38
|
T: 62 ± 7.0
C: 60.5 ± 7.0
|
Radiation, chemotherapy
|
Aerobic exercise modality: Continuous. Time: 150 min/w. Frequency: 2 sessions /w. Duration: 12m Intensity: started at 50% of HRmax and increased over the 1st month to 60–80% of HRmax
|
Linear
|
⑤
|
de Paulo et al48. (2018)
|
RCT. Single-center
|
I - III
|
18
|
18
|
T: 63.2 ± 7.1
C: 66.6 ± 9.6
|
Aromatase inhibitor therapy
|
Aerobic exercise modality: Continuous. Time: 1-2nd week: 20min. 3-36th week: 30min. Frequency: 3 sessions /w. Duration: 36w. Intensity: 1-2nd w: 50–60% HRmax. 3-10th w: 60–65% HRmax. 11-18th w: 65–70% HRmax. 19-28th w: 70–75% HRmax. 20-36th w: 75–80% HRmax
|
Linear
|
⑩⑪⑫⑬⑰⑲⑳㉑
|
Møller et al27. (a) (2015)
|
RCT. Single-center
|
I - III
|
9
|
10
|
T:57.17 ± 10.51
C: 46.95 ± 9.19
|
AC & TAX & CYC
|
Aerobic exercise modality: Continuous & Interval. Time: 60–90 min/ sessions. Frequency: 3 sessions /w. Duration: 12w. Intensity: 95–95% HRmax
|
Nonlinear
|
⑤⑥⑪⑫⑬
|
Møller et al27. (b) (2015)
|
RCT. Single-center
|
I - III
|
10
|
10
|
T: 48.49 ± 8.41
C:46.95 ± 9.19
|
AC & TAX & CYC
|
Aerobic exercise modality: Continuous. Time: 30 min/ sessions. Frequency: 5 sessions /w. Duration: 12w. Intensity: 70–75% HRmax
|
Linear
|
⑤⑥⑪⑫⑬
|
Ma et al49. (2018)
|
RCT. Single-center
|
-
|
31
|
33
|
T: 44 ± 6
C: 44 ± 6
|
AC
|
Aerobic exercise modality: Interval. Time: 50 min/ sessions. Frequency: 3 sessions/w. Duration: 16w. Intensity: Work: 90–95% HRmax. Rest: 50 − 70% HRmax
|
Linear
|
⑤㉒
|
Al-Majid et al50. (2015)
|
RCT. Single-center
|
I - II
|
6
|
7
|
T: 52.7 ± 10.7
C: 47.9 ± 10.4
|
Adjuvant chemotherapy
|
Aerobic exercise modality: Continuous. Time: 20–40 min/ sessions. Frequency: 1st w: 2 sessions, 2nd -12th w: 3 sessions/w. Duration: 12w. Intensity: 1st w: 40% − 50% HRR. 2nd -3rd w: 50% − 70% HRR. 4th -12th w: 70% − 80% HRR
|
Nonlinear
|
⑤
|
Jones et al51. (2013)
|
RCT. Single-center
|
0 to IIIA
|
36
|
31
|
T: 56.4 ± 9.6
C: 55.4 ± 7.6
|
Adjuvant chemotherapy
|
Aerobic exercise modality: Continuous. Time: 15min for week 1, and then gradually increased minutes of exercise per week to 30 min for weeks 5 through 12. Frequency: 5 sessions/w. Duration: 6m. Intensity: started at 50% HRmax to 60% − 80% HRmax
|
Nonlinear
|
㉑
|
Rogers et al52. (2009)
|
RCT. Single-center
|
I, II, or IIIA
|
20
|
19
|
T: 52 ± 15
C: 54 ± 8
|
Aromatase inhibitors or selective estrogen receptor modulators
|
Aerobic exercise modality: Continuous. Time: 40–45 min / sessions. Frequency: 1st -2nd week: 3 sessions/w. 3rd -6th week: 4 sessions/w. 7th -12th week: 5 sessions/w. Duration: 12w. Intensity: moderate intensity
|
Nonlinear
|
⑥⑫⑯
|
Dieli-Conwright et al28. (a) (2021)
|
RCT. Single-center
|
I - III; Hispanic ethnicity
|
28
|
24
|
T: 46.9 ± 10.2
C: 46.7 ± 10
|
Surgery, radiation, chemotherapy
|
Aerobic exercise modality: Continuous. Time: 5 minutes every 3–4 weeks resulting in a total of 45 minutes of aerobic exercise per session by 16th w. Frequency: 3 sessions/w. Duration: 16w. Intensity: 65–80% HR max
|
Nonlinear
|
⑤
|
Dieli-Conwright et al28. (b) (2021)
|
RCT. Single-center
|
I - III; Non-Hispanic ethnicity
|
19
|
22
|
T: 55.6 ± 10.5
C: 55.9 ± 10.3
|
Surgery, radiation, chemotherapy
|
Aerobic exercise modality: Continuous. Time: 5 minutes every 3–4 weeks resulting in a total of 45 minutes of aerobic exercise per session by 16th w. Frequency: 3 sessions/w. Duration: 16w. Intensity: 65–80% HR max
|
Nonlinear
|
⑤
|
Nuri et al53. (2012)
|
RCT. Single-center
|
I to IIIB
|
14
|
15
|
T: 58.27 ± 6.31
C: 58.27 ± 6.31
|
Hormone therapy
|
Aerobic exercise modality: Continuous. Time: Start with 25 minutes and increase by 10 minutes every 5 weeks. Frequency: 2 sessions/w. Duration: 15w. Intensity: 45–65% HR max
|
Nonlinear
|
⑤⑥⑩⑭⑮⑯⑰⑳
|
Lahart et al54. (2018)
|
RCT. Single-center
|
I - III
|
16
|
16
|
T: 52.5 ± 10.7
C: 52 ± 8.6
|
|
Aerobic exercise modality: Continuous. Time: 1st -3rd month: 30 min/sessions. 4th -6th month: >30 min/sessions. Frequency: 1st -3rd m: 3–5 sessions /w. 4th -6th m: 5–7 sessions /w. Duration: 24w. Intensity: Moderate -vigorous
|
Nonlinear
|
⑤
|
Rogers et al55. (2013)
|
RCT. Single-center
|
I, II or IIIA
|
11
|
9
|
T: 58 ± 6.1
C: 53.7 ± 13.9
|
|
Aerobic exercise modality: Continuous. Time: 150 min/w. Duration: 12w. Intensity: Moderate intensity
|
Linear
|
⑤⑥⑫ ⑯
|
Guinan et al56. (2013)
|
RCT. Single-center
|
I - III
|
16
|
10
|
T: 50.05 ± 8.27
C: 45.05 ± 9.04
|
Adjuvant hormone therapy and anti-Her2 directed therapy
|
Aerobic exercise modality: Continuous. Time: 21-42min /sessions. Frequency: 21-42min /sessions. Duration: 8w. Intensity: 30% − 75% HRR
|
Nonlinear
|
⑮⑰⑱⑲⑳
|
Herrero et al57. (2011)
|
RCT. Single-center
|
I - II
|
8
|
8
|
T: 50.05 ± 8.27
C:45.05 ± 9.04
|
CFM
|
Aerobic exercise modality: Continuous. Time: Gradually increased from 20min to 30min per session. Frequency: 2 sessions /w. Duration: 8w. Intensity: Gradually increased from 30–75% HRR
|
Nonlinear
|
⑤⑩⑪⑫
|
Ligibel et al58. (2008)
|
RCT. Single-center
|
I - III
|
42
|
40
|
T: 52 ± 9
C:53 ± 9
|
chemotherapy and/or radiation therapy
|
Aerobic exercise modality: Continuous. Time: 90 min / sessions. Frequency: 2 sessions /w. Duration: 16w. Intensity: Moderate intensity
|
Linear
|
⑥⑩⑫⑭⑮⑯
|
Lahart et al59. (2016)
|
RCT. Single-center
|
I - III
|
40
|
40
|
T: 52.4 ± 10.3
C: 54.7 ± 8.3
|
Radiation therapy and/or chemotherapy
|
Aerobic exercise modality: Continuous. Time: 30 min / sessions. Frequency: 5 sessions /w. Duration: 12w. Intensity: Moderate intensity
|
Linear
|
⑥⑩⑫ ⑰⑱⑲⑳
|
DeNysschen et al60. (2010)
|
RCT. Single-center
|
I - III
|
36
|
30
|
T: 48.7 ± 8.4
C: 49.5 ± 9.5
|
Chemotherapy
|
Aerobic exercise modality: Continuous. Time: 20–30 min / sessions. Frequency: 3–5 sessions /w. Duration: 4-6m. Intensity: 60–80% VO2peak
|
Nonlinear
|
⑩⑫⑬
|
Kim et al23. (a) (2021)
|
Cohort trial. Single-center
|
-
|
11154
|
7410
|
T: 50.9 ± 9.6
C: 53.1 ± 10.1
|
Radiotherapy, cardiotoxic chemotherapy, aromatase inhibitor, Tamoxifen
|
Aerobic exercise modality: Continuous. Time: 1-499 MET-mins/week. Duration: 5 year. Intensity: Low
|
Linear
|
①②③
|
Kim et al23. (b) (2021)
|
11110
|
7410
|
T: 50.9 ± 9.4
C: 53.1 ± 10.1
|
Aerobic exercise modality: Continuous. Time: 1-499 MET-mins/week. Duration: 5 year. Intensity: Medium
|
Linear
|
①②③
|
Kim et al23. (c) (2021)
|
10101
|
7410
|
T: 50.6 ± 8.4
C: 53.1 ± 10.1
|
Aerobic exercise modality: Continuous. Time: 1-499 MET-mins/week. Duration: 5 year. Intensity: High
|
Linear
|
①②③
|
Jones et al24. (a) (2016)
|
Cohort trial. Single-center
|
I - III
|
747
|
741
|
T: 56.6 ± 10.5
C: 58.7 ± 10.4
|
Surgery, chemotherapy, radiotherapy, tamoxifen or aromatase inhibitor
|
Aerobic exercise modality: Continuous. Duration: 5 year. Intensity-Time: 5.4 MET-h/week
|
Linear
|
①②④
|
Jones et al24. (b) (2016)
|
741
|
741
|
T: 57.2 ± 10.3
C: 58.7 ± 10.4
|
Aerobic exercise modality: Continuous. Duration: 5 year. Intensity-Time: 16.3 MET-h/week
|
Linear
|
①②④
|
Jones et al24. (c) (2016)
|
744
|
741
|
T: 55.4 ± 10.5
C: 58.7 ± 10.4
|
Aerobic exercise modality: Continuous. Duration: 5 year. Intensity-Time: 40 MET-h/week
|
Linear
|
① ②④
|