This paper introduces an approach that combines macroeconomic forecasts with the input-output analysis methods to produce long-term projections of input-output tables (IOTs), with an emphasis on key targets of Saudi Vision 2030, Saudi Arabia’s blueprint for economic diversification and sustainable growth. A significant advantage of the input-output framework is its high sectoral granularity, allowing it to capture the impacts of adjustments to final demand or government policies with respect to individual sectors. Our hybrid approach enables the introduction of different sectoral growth paths, so that Vision 2030’s transformation plan is reflected appropriately in the projected IOTs. The framework is flexible enough to accommodate sudden adjustments with relative ease, such as the introduction of new technologies or entire sectors into the economy. Saudi Vison 2030 includes a set of targets relating to economic diversification into non-oil sectors, improved energy efficiency, the introduction of new technologies, social transformation, and the support of selected emerging sectors. The ultimate aim of the vision is to create an acceleration towards sustainable growth and development in the Saudi economy. Since these policies are expected to have a substantial impact on the economy, quantifying the economic implications of diversification and sectoral shifts require an adequate and flexible tool for projecting and evaluating structural adjustments for a better decision making.