This technical study analyzes heat and mass transfer effects on the flow of a peristaltic flow, incompressible, nanofluid via a ciliated tube. The investigation considers the approximation of long wavelength and low Reynolds number. The flow is examined in wave frame of reference moving with the velocity c. The governing equations have been solved to determine velocity, temperature, concentration, the gradient pressure, rise pressure and the friction force. Using MATLAB R2023a software, a parametric analysis is performed, and the resulting data is represented graphically. The results indicate that the various emerging parameters of interest significantly affect the fluid properties within the tube. The present study enhances the comprehension of fluid dynamics in tube and offers valuable insights into the influence of heat and mass transfer in such setups.