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Availability of data and materials
Proteomics data were deposited into the Pride repository (www.ebi.ac.uk/pride) under accession number PXD017863, PXD021501 and PXD021475. Lipidomics data were deposited into the Massive repository (http://massive.ucsd.edu/) under accession number MSV000086174.
Pla2g6-dependent cytokine signaling in MIN6 cells
Project number: PXD017863
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ARH3-regulated cytokine signaling in MIN6 cells
Project accession: PXD021501
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Password: NbhKnd9N
Proteomics analysis of islets of 6-week old NOR and NOD mice
Project accession: PXD021475
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Lipidomics of 3 models of insulitis, beta-cell stress and type 1 diabetes development
Project accession: MSV000086174
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Username: MSV000086174_reviewer
Password: Islets3663
Competing interests
The authors declare that they have no competing interests.
Funding
This work was supported by National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) grants U01 DK127505 (to L.S. and E.S.N.), UC4 DK108101 (to C.A. and L.S.), UC4 DK104166 (to R.G.M, C.E. M., D.L.E, and T.O.M.), U01 DK127786 (to R.G.M, C.E. M., D.L.E, B.J.M.W.R and T.O.M.), R01 DK105588 (to R.G.M.) R01 DK126444 (to D.L.E.) and R01 DK093954 (to C.E.M); VA Merit Award I01BX001733 (to C.E.M.); Fonds National de la Recherche Scientifique (FNRS), Welbio CR-2015A-06, Belgium (to D.L.E.); a JDRF Strategic Research Agreement (to C.E.M and R.G.M.) and gifts from the Sigma Beta Sorority, the Ball Brothers Foundation, the George and Frances Ball Foundation, and the Holiday Management Foundation (to C.E.M and R.G.M.). F.S. was supported by JDRF postdoctoral fellowship (3-PDF-2016-199-A-N) and JDRF career development Award (JDRF 5-CDA-2022-1176-A-N). D.L.E. also received funds from a JDRF Strategic Research Agreement. E.S.N. was also supported by NIDDK grant U54 DK127823, Human Islet Research Network Catalyst Award, and by the Laboratory Directed Research and Development Program at Pacific Northwest National Laboratory, a multiprogram national laboratory operated by Battelle for the U.S. Department of Energy and Exploratory Research Seed Grant funding from the OHSU School of Medicine.
Authors’ contributions
E.S.N., L.S., C.A. conceived the study and participated in the study design. E.S.N., S.S., M.G., J.K., D.S., C.D., R.Y., Y.C., C.N., F.S., and J.J.M. performed the experiments. All the authors performed the data analysis. E.S.N., S.S., R.Y., Y.C., B.J.W.R., J.L., L.S. and C.A. wrote the manuscript. All authors read, revised, and approved the final manuscript for publication.
Acknowledgments
The authors thank the NIDDK-supported Integrated Islet Distribution Program (IIDP) for providing the human islets used in the study. Work was performed in the Environmental Molecular Sciences Laboratory, a U.S. Department of Energy (DOE) national scientific user facility at Pacific Northwest National Laboratory (PNNL) in Richland, WA. Battelle operates PNNL for the DOE under contract DE-AC05-76RLO01830.