See the published version of this article at Annals of General Psychiatry.
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Case report
Severe Fatigue Due to Valproate-induced Hypothyroidism in a Case of Bipolar Disorder
Masahiro Suzuki
Nihon University School of Medicine
Corresponding Author
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This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Annals of General Psychiatry.
Background: Valproate-induced hypothyroidism is a rare conditionand has been considered asymptomatic. Here, we report a case of bipolar I disorder who developed symptomatic valproate-induced hypothyroidism.
Case presentation: A 44-year-old woman with bipolar I disorder complained of severe fatigue after starting valproate. She showed a hormonal pattern of central hypothyroidism. Thyroid autoantibodies were negative, and no pituitary abnormality was seen on magnetic resonance imaging. After stopping valproate, her severe fatigue rapidly improved with normalizing thyroid function.
Conclusions:Our case suggests that valproate-induced hypothyroidism should be considered when patients complain of excessive fatigue under treatment with valproate.
Keywords
bipolar disorder, hypothyroidism, symptomatic, valproate
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CURRENT STATUS: Published
Version 1
Posted 04 Jun, 2020
Published
On 05 Sep, 2020
No community comments so far
Review #2 received
Received 29 Jul, 2020
Editorial decision: Major revision
On 29 Jul, 2020
Reviewer #2 agreed
On 16 Jul, 2020
Review #1 received
Received 13 Jul, 2020
Reviewer #1 agreed
On 25 Jun, 2020
Reviewers invited
Invitations sent on 20 Jun, 2020
First submitted
On 30 May, 2020
Editor assigned
On 30 May, 2020
Submission checks complete
On 29 May, 2020
Editor invited
On 29 May, 2020
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Subject Areas
Psychiatry
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This preprint is under consideration at Annals of General Psychiatry. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Case report
Severe Fatigue Due to Valproate-induced Hypothyroidism in a Case of Bipolar Disorder
Masahiro Suzuki
Nihon University School of Medicine
Corresponding Author
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 1
Posted 04 Jun, 2020
Published
On 05 Sep, 2020
No community comments so far
Review #2 received
Received 29 Jul, 2020
Editorial decision: Major revision
On 29 Jul, 2020
Reviewer #2 agreed
On 16 Jul, 2020
Review #1 received
Received 13 Jul, 2020
Reviewer #1 agreed
On 25 Jun, 2020
Reviewers invited
Invitations sent on 20 Jun, 2020
First submitted
On 30 May, 2020
Editor assigned
On 30 May, 2020
Submission checks complete
On 29 May, 2020
Editor invited
On 29 May, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Psychiatry
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at Annals of General Psychiatry.
Background: Valproate-induced hypothyroidism is a rare conditionand has been considered asymptomatic. Here, we report a case of bipolar I disorder who developed symptomatic valproate-induced hypothyroidism.
Case presentation: A 44-year-old woman with bipolar I disorder complained of severe fatigue after starting valproate. She showed a hormonal pattern of central hypothyroidism. Thyroid autoantibodies were negative, and no pituitary abnormality was seen on magnetic resonance imaging. After stopping valproate, her severe fatigue rapidly improved with normalizing thyroid function.
Conclusions:Our case suggests that valproate-induced hypothyroidism should be considered when patients complain of excessive fatigue under treatment with valproate.