Severe Fatigue Due to Valproate-induced Hypothyroidism in a Case of Bipolar Disorder
Background: Valproate-induced hypothyroidism is a rare conditionand has been considered asymptomatic. Here, we report a case of bipolar I disorder who developed symptomatic valproate-induced hypothyroidism.
Case presentation: A 44-year-old woman with bipolar I disorder complained of severe fatigue after starting valproate. She showed a hormonal pattern of central hypothyroidism. Thyroid autoantibodies were negative, and no pituitary abnormality was seen on magnetic resonance imaging. After stopping valproate, her severe fatigue rapidly improved with normalizing thyroid function.
Conclusions:Our case suggests that valproate-induced hypothyroidism should be considered when patients complain of excessive fatigue under treatment with valproate.
Posted 04 Jun, 2020
On 05 Sep, 2020
Received 29 Jul, 2020
On 29 Jul, 2020
On 16 Jul, 2020
Received 13 Jul, 2020
On 25 Jun, 2020
Invitations sent on 20 Jun, 2020
On 30 May, 2020
On 30 May, 2020
On 29 May, 2020
On 29 May, 2020
Severe Fatigue Due to Valproate-induced Hypothyroidism in a Case of Bipolar Disorder
Posted 04 Jun, 2020
On 05 Sep, 2020
Received 29 Jul, 2020
On 29 Jul, 2020
On 16 Jul, 2020
Received 13 Jul, 2020
On 25 Jun, 2020
Invitations sent on 20 Jun, 2020
On 30 May, 2020
On 30 May, 2020
On 29 May, 2020
On 29 May, 2020
Background: Valproate-induced hypothyroidism is a rare conditionand has been considered asymptomatic. Here, we report a case of bipolar I disorder who developed symptomatic valproate-induced hypothyroidism.
Case presentation: A 44-year-old woman with bipolar I disorder complained of severe fatigue after starting valproate. She showed a hormonal pattern of central hypothyroidism. Thyroid autoantibodies were negative, and no pituitary abnormality was seen on magnetic resonance imaging. After stopping valproate, her severe fatigue rapidly improved with normalizing thyroid function.
Conclusions:Our case suggests that valproate-induced hypothyroidism should be considered when patients complain of excessive fatigue under treatment with valproate.