Atmospheric precipitation causes some mining faces, mining areas or mines to be flooded every year. In order to explore the relationship between atmospheric precipitation and mine water inflow under Karst geomorphic conditions in Guizhou Province, some typical mine related data were collected systematically. It was found that atmospheric precipitation can supply mine goaf through weathered zone cracks, mining fissures, water conducting faults, water flowing subsided columns and karst channels. These channels are in the form of surface infiltration, pipeline flow and layered recharge Replenish the goaf. The results show that the mine water inflow is significantly affected by rainfall under all kinds of recharge modes, the correlation between them is significant under layered recharge mode,the correlation coefficient R reaches 0.88. The recharge channel is filled by loess and other materials on the surface, and has the self-healing characteristics of gradual plugging; the recharge amount is affected by the burial depth of coal seam and the rock combination characteristics of the upper roof. The deeper the coal seam is, the worse the recharge effect is to the mine. The results show that the atmospheric precipitation is the main water filling source of coal mine stope water inflow in the study area, and its recharge has seasonal characteristics. The mine water inflow in rainy season is 1.2-12 times of that in dry season, with an average of 1.9 times; the recharge of mine water by atmospheric precipitation has hysteresis, the lag time of surface infiltration recharge mine is generally 1-4 days, and the lag time of pipeline flow replenishing mine is generally 24 hours In general, the time lag of laminar flow recharge to mine is more than 2 days.