See the published version of this preprint at BMC Infectious Diseases.
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Research article
Mohammad Sajjad Rahnama'i
Maastricht University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1953-7441
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background:
The type of pneumonia that is caused by the new coronavirus (SARS-CoV-2) has spread across the world in a pandemic. It is not clear if COVID-19 patients have any lower urinary tract signs or symptoms.
Methods:
The effect of COVID-19 on lower urinary tract function was studied in a multi-centre study including 238 patients who were admitted with symptoms caused by COVID-19 to the university hospital of Aachen in Germany and Tabriz in Iran.
Results:
None of the patients reported to have any lower urinary tract symptoms. SARS-CoV-2 was found in the urine of 19 % of the tested patients.
The mortality rate in COVID-19 infected patients with microscopic haematuria together with white blood cells in their urine, was significantly increased from 48% to 61% in the Tabriz cohort (p-value=0.03) and from 30 % to 35% in the Aachen cohort (p-value =0.045). Furthermore, in the group of patients with SARS-CoV-2 urine PCR, the mortality rate rose from 33% to 50%. (p-value =0.039).
Conclusion:
Patients admitted with COVID-19 infection did not report to have any lower urinary tract symptoms even those patient who had a positive Urine SARS-CoV-2 PCR.
In addition, hematuria, WBC in urine as well as COVID-19 positivity in urine were found to be strong negative prognostic factors in admitted COVID-19 patients.
Keywords
COVID-19, lower urinary tract signs, pneumonia
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View the published article at BMC Infectious Diseases.
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Review #1 received
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On 02 Apr, 2021
Reviewer #4 agreed
On 31 Mar, 2021
Reviewer #3 agreed
On 30 Mar, 2021
Reviewer #2 agreed
On 30 Mar, 2021
Reviewer #1 agreed
On 27 Mar, 2021
Editor assigned
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See the published version of this preprint at BMC Infectious Diseases.
This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Mohammad Sajjad Rahnama'i
Maastricht University
Corresponding Author
ORCiD: https://orcid.org/0000-0003-1953-7441
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
View the published article at BMC Infectious Diseases.
Version 1
Posted 22 Mar, 2021
No community comments so far
Review #3 received
Received 14 Apr, 2021
Review #4 received
Received 11 Apr, 2021
Review #1 received
Received 09 Apr, 2021
Review #2 received
Received 03 Apr, 2021
Reviewer #5 agreed
On 02 Apr, 2021
Reviewer #4 agreed
On 31 Mar, 2021
Reviewer #3 agreed
On 30 Mar, 2021
Reviewer #2 agreed
On 30 Mar, 2021
Reviewer #1 agreed
On 27 Mar, 2021
Editor assigned
On 08 Mar, 2021
Reviewers invited
Invitations sent on 08 Mar, 2021
Submission checks complete
On 08 Mar, 2021
Editor invited
On 08 Mar, 2021
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Infectious Diseases
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published article at BMC Infectious Diseases.
Background:
The type of pneumonia that is caused by the new coronavirus (SARS-CoV-2) has spread across the world in a pandemic. It is not clear if COVID-19 patients have any lower urinary tract signs or symptoms.
Methods:
The effect of COVID-19 on lower urinary tract function was studied in a multi-centre study including 238 patients who were admitted with symptoms caused by COVID-19 to the university hospital of Aachen in Germany and Tabriz in Iran.
Results:
None of the patients reported to have any lower urinary tract symptoms. SARS-CoV-2 was found in the urine of 19 % of the tested patients.
The mortality rate in COVID-19 infected patients with microscopic haematuria together with white blood cells in their urine, was significantly increased from 48% to 61% in the Tabriz cohort (p-value=0.03) and from 30 % to 35% in the Aachen cohort (p-value =0.045). Furthermore, in the group of patients with SARS-CoV-2 urine PCR, the mortality rate rose from 33% to 50%. (p-value =0.039).
Conclusion:
Patients admitted with COVID-19 infection did not report to have any lower urinary tract symptoms even those patient who had a positive Urine SARS-CoV-2 PCR.
In addition, hematuria, WBC in urine as well as COVID-19 positivity in urine were found to be strong negative prognostic factors in admitted COVID-19 patients.
Figure 1
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