Previous research work suggests that predictable target motion such as sinusoidal movement can be anticipated by the visual system, thereby improving the accommodative response. The validity of predictable motion for studying human dynamic accommodation is sometimes put into question. The aim of this work was to assess from a practical perspective the effect of anticipation along with learning (and motivation, etc.) and fatigue (and boredom, loss of attention, etc.) on dynamic accommodation experiments. Specifically, changes in amplitude and temporal phase were estimated within and between trials as 9 adult observers were instructed to focus on a stimulus that oscillated in distance at specific temporal frequencies. On average, amplitude decreased whereas phase increased within trials. No evidence of anticipation or learning was observed either within or between trials. Fatigue consistently dominated anticipation and learning within the course of each trial. Even if the eye is equipped by a “prediction operator”, in practice, it is fatigue, and not anticipation or learning, that seems to muddle the results from dynamic accommodation experiments.