This paper is aimed to analyze and control the structure vibration of a vehicle steering wheel by using the acceleration transfer path analysis (TPA) method and vibration sensitivity method. A steering wheel vibration test is conducted to obtain the critical engine speed and corresponding to the frequency. The acceleration-acceleration transfer function from mounts body side to steering wheel is deducted and tested, in conjunction with the actual acceleration spectrums of mounts body side, the acceleration spectrum of steering wheel is synthesized and the accuracy of the synthetic results is evaluated high. Then the vibration transmitted by each path is investigated and the main vibration participation paths are picked out from numerous paths. The interaction mechanisms between the path transfer vibration, path vibration participation and the total vibration are further obtained. The critical parameters (mounting stiffnesses and vibration sensitivity) of the main vibration participation paths are matched, modified and the vibration control effect is experimental verified. The results indicate that, by pertinently matching the stiffness parameters of the mounts and reducing vibration sensitivity of structure, the dynamic force transmitted by the paths are decreased, the vibration transfer functions from mounts body side to steering wheel are decreased, and then the actual steering wheel vibration is controlled.