Cellulose nanocrystal (CNC) has a high prospect in the biomedical field due to its favourable biocompatibility, stability, and modifiable properties, which render it potentially useful as a template for silver deposition nanoparticles (Ag NPs). In this research work, the aim was to prepare AgNPs on carboxylate nanocrystal cellulose (cCNC) in a minimised process and decrease the number of chemical reagents and with a stable anchor and controllable release Ag + by hydrothermal reaction. The controlled release of Ag+ was also determined. The anticancer activity of Ag-cCNC on HCT116 (Human colon cancer cells) and SK-MEL-2 (Human Skin Melanoma cells) were investigated. Silver nanoparticles were uniformly deposited onto cCNC with a 28.0% yield and a particle size of ∼15 nm. The release rate of silver ions was monitored for 32 days by ICOES analysis. It was found that Ag-cCNC induced silver ions to release slowly, which displayed a controllable release of silver ions with a rate of 0.1-0.2% per 2 days and a longterm release of 245 days. Also, Ag-cCNC showed anticancer activity against both HCT 116 (Human colon cancer cell) and SK-MEL-2 (Human Skin Melanoma cell) at 35±4.04% and 20±7.68% cell viability, respectively. Ag-cCNC showed promising higher 15% anticancer HCT 116 efficacy than cisplatin, but it was lower 18% in anticancer SK-MEL-2. This study provides a novel, sustainable, simple and straightforward way with environmentally friendly to produce and use natural composite material from Eucalyptus as an antitumour drug.
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Posted 22 Mar, 2021
Received 19 Mar, 2021
Invitations sent on 18 Mar, 2021
On 17 Mar, 2021
On 15 Mar, 2021
Posted 22 Mar, 2021
Received 19 Mar, 2021
Invitations sent on 18 Mar, 2021
On 17 Mar, 2021
On 15 Mar, 2021
Cellulose nanocrystal (CNC) has a high prospect in the biomedical field due to its favourable biocompatibility, stability, and modifiable properties, which render it potentially useful as a template for silver deposition nanoparticles (Ag NPs). In this research work, the aim was to prepare AgNPs on carboxylate nanocrystal cellulose (cCNC) in a minimised process and decrease the number of chemical reagents and with a stable anchor and controllable release Ag + by hydrothermal reaction. The controlled release of Ag+ was also determined. The anticancer activity of Ag-cCNC on HCT116 (Human colon cancer cells) and SK-MEL-2 (Human Skin Melanoma cells) were investigated. Silver nanoparticles were uniformly deposited onto cCNC with a 28.0% yield and a particle size of ∼15 nm. The release rate of silver ions was monitored for 32 days by ICOES analysis. It was found that Ag-cCNC induced silver ions to release slowly, which displayed a controllable release of silver ions with a rate of 0.1-0.2% per 2 days and a longterm release of 245 days. Also, Ag-cCNC showed anticancer activity against both HCT 116 (Human colon cancer cell) and SK-MEL-2 (Human Skin Melanoma cell) at 35±4.04% and 20±7.68% cell viability, respectively. Ag-cCNC showed promising higher 15% anticancer HCT 116 efficacy than cisplatin, but it was lower 18% in anticancer SK-MEL-2. This study provides a novel, sustainable, simple and straightforward way with environmentally friendly to produce and use natural composite material from Eucalyptus as an antitumour drug.
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