Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein
The CR3022 antibody, selected from a group of SARS-CoV-1 monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using electron cryo-microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.
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Posted 05 Jun, 2020
On 21 Oct, 2020
Antibody-mediated disruption of the SARS-CoV-2 spike glycoprotein
Posted 05 Jun, 2020
On 21 Oct, 2020
The CR3022 antibody, selected from a group of SARS-CoV-1 monoclonal antibodies for its ability to cross-react with SARS-CoV-2, has been examined for its ability to bind to the ectodomain of the SARS-CoV-2 spike glycoprotein. Using electron cryo-microscopy we show that antibody binding requires rearrangements in the S1 domain that result in dissociation of the spike.
Figure 1
Figure 2