Sources of Funding: This work was partially supported by Grant R61HD105591 from the Eunice Kennedy Shriver National Institute of Child Health & Human Development and the Office of the Director, National Institute of Health (OD). Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the Eunice Kennedy Shriver National Institute of Child Health & Human Development or the Office of the Director, National Institute of Health (OD). Dr. Truong is supported by NIH OTA-21-015E, to study genetic risk factors for the development of MIS-C and more severe disease; and NIH/NHLBI OT2HL161847-01, to characterize the clinical spectrum of post-acute sequelae of COVID-19 (PASC), organ dysfunction in sub-phenotypes of PASC, and the underlying biological mechanisms. Dr. Portman is supported by R01 HL143130. Dr. Dahdah is supported by BoBeau Coeur funds for applied clinical research in pediatric cardiology. Dr. Dionne is supported by McCance Family Fund
Disclosures: Dr. Truong is an MPI on an NHLBI Pediatric Heart Network-Pfizer Partnership to Study COVID-19 Vaccine-Associated Myocarditis. Dr. Harahsheh serves as a scientific advisory board member of OP2 DRUGS (“OP2”) but this advisory position has no relevant disclosures for this manuscript.
Acknowledgements: The team of the IKDR Coordinators and Primary Investigators from all participating centers: Abdelwahab Ahmed (Pediatric Cardiology Division, Department of Pediatrics, Ain-Shams University, Cairo, Egypt), Jessica Bainton (Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada), Annette L. Baker (Boston Children's Hospital, Harvard Medical School, Boston, MA, USA), Mikayla A. Beckley (Seattle Children's Research Institute, Seattle, WA, USA), Bailey Bernknopf (Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada), Jacobo Borovoy-Gurwitz (Hospital Angeles Lomas, Huixquilucan, Mexico), Jane C. Burns (University of California San Diego/Rady Children’s Hospital San Diego, CA USA), Ana Caro Barri (Hospital 12 de Octubre (Imas12), Madrid, Spain), Tanveer Collins (Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada), Amy Cooper (The Heart Center at Nationwide Children's Hospital, Columbus, OH, USA), Jamie Cruz (Hospital 12 de Octubre (Imas12), Madrid, Spain), Catherine Dimes (The Heart Center at Nationwide Children's Hospital, Columbus, OH, USA), Elías Duck-Hernández (Hospital Angeles Lomas, Huixquilucan, Mexico), Manar Elansary (Pediatric Cardiology Division, Department of Pediatrics, Ain-Shams University, Cairo, Egypt), Kevin G. Friedman (Boston Children's Hospital, Harvard Medical School, Boston, MA, USA), Fiorentina Guida (Pediatric Emergency Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy), Jonathan Hazlewood (Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada), Ashley Herzberg (Phoenix Children's Hospital, Phoenix, AZ, USA), Kelli Kaneta (Children's Hospital of Los Angeles, Los Angeles, CA, USA), Katherine Kanwar (The Heart Center at Nationwide Children's Hospital, Columbus, OH, USA), Jong Mi Ko (Johns Hopkins School of Medicine, Baltimore MD, USA), Rita Long (Johns Hopkins School of Medicine, Baltimore MD, USA), Simran Mahanta (Boston Children's Hospital, Harvard Medical School, Boston, MA, USA), Sara Mahfouz (Pediatric Cardiology Division, Department of Pediatrics, Ain-Shams University, Cairo, Egypt), Irene Maulen-Radovan (Hospital Angeles Lomas, Huixquilucan, Mexico), Matteo Meli (Pediatric Emergency Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Bologna, Italy), Sahar Mohamed (Kingston Health Science Centre, Kingston, ON, Canada), Deepthi G. Nair (Seattle Children's Research Institute, Seattle, WA, USA), Divya Nandakumar (Kanchi Kamakoti Childs Trust Hospital, Chennai, India), Jane W. Newburger (Boston Children's Hospital, Harvard Medical School, Boston, MA, USA), Martin Ogwuru (Kingston Health Science Centre, Kingston, ON, Canada), Sunita O'Shea (Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada), Susan S. Park (Phoenix Children's Hospital, Phoenix, AZ, USA), Jade Porche (Phoenix Children's Hospital, Phoenix, AZ, USA), Sulochana Putlibai (Kanchi Kamakoti Childs Trust Hospital, Chennai, India), Itzel Estefani Ríos-Olivares (Instituto Nacional de Pediatría, Mexico City, Mexico), Martha Rolland (Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada), Christina Hayden Rush (Children's Hospital of Philadelphia, Philadelphia, PA, USA), Kristy Rutt (Banner Children's at Desert Medical Center, Mesa, AZ, USA), Senthilnathan S. (Kanchi Kamakoti Childs Trust Hospital, Chennai, India), Seaher Sakha (Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada), Mina Sidhom (Pediatric Cardiology Division, Department of Pediatrics, Ain-Shams University, Cairo, Egypt), John Smythe (Kingston Health Science Centre, Kingston, ON, Canada), Samantha Stack (Phoenix Children's Hospital, Phoenix, AZ, USA), Amullya Sudhakar (Kanchi Kamakoti Childs Trust Hospital, Chennai, India), Sharon Wagner-Lees (Children's Hospital of Los Angeles, Los Angeles, CA, USA), Patricia Walter (Labatt Family Heart Centre, The Hospital for Sick Children, Department of Pediatrics, University of Toronto, Toronto, ON, Canada)