This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Short Report
Zohreh Rahimi
Kermanshah University of Medical Sciences, Kermanshah, Iran
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7589-3307
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Infection with coronavirus disease 2019 (COVID-19) could be complicated with coagulopathy and high risk of thromboembolic events.
Methods: Coagulation parameters were analyzed in 74 confirmed severe COVID-19 patients admitted to the intensive care unit of Farabi University Hospital, Kermanshah, Western Iran.
Results: Around 42% of patients had abnormal prothrombin time (PT) and international normalized ratio (INR). The rate of abnormal coagulation parameters in the mean age 76.6±7.7 and 46.6±10.3 years were 62 and 38%, respectively. Patients with comorbidities had significantly longer PT and higher INR that increased the rate of mortality to around 77% in these individuals. The abnormal pattern of coagulation parameters was highly associated with comorbidities and poor prognosis.
Conclusions: Our study demonstrated abnormal coagulation parameters and a high rate of coagulopathy in hospitalized patients with COVID-19 that was associated with age, comorbidities and mortality which should be considered in management of these patients.
Keywords
COVID-19, coagulation, prothrombin time, international normalized ratio, D-dimer
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This is a preprint, a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Short Report
Zohreh Rahimi
Kermanshah University of Medical Sciences, Kermanshah, Iran
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7589-3307
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 09 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Hematology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Infection with coronavirus disease 2019 (COVID-19) could be complicated with coagulopathy and high risk of thromboembolic events.
Methods: Coagulation parameters were analyzed in 74 confirmed severe COVID-19 patients admitted to the intensive care unit of Farabi University Hospital, Kermanshah, Western Iran.
Results: Around 42% of patients had abnormal prothrombin time (PT) and international normalized ratio (INR). The rate of abnormal coagulation parameters in the mean age 76.6±7.7 and 46.6±10.3 years were 62 and 38%, respectively. Patients with comorbidities had significantly longer PT and higher INR that increased the rate of mortality to around 77% in these individuals. The abnormal pattern of coagulation parameters was highly associated with comorbidities and poor prognosis.
Conclusions: Our study demonstrated abnormal coagulation parameters and a high rate of coagulopathy in hospitalized patients with COVID-19 that was associated with age, comorbidities and mortality which should be considered in management of these patients.
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