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Short Report
Blood Coagulation Parameters in Patients with Severe COVID-19
Zohreh Rahimi
Kermanshah University of Medical Sciences, Kermanshah, Iran
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7589-3307
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This work is licensed under a CC BY 4.0 License. Read Full License
Background: Infection with coronavirus disease 2019 (COVID-19) could be complicated with coagulopathy and high risk of thromboembolic events.
Methods: Coagulation parameters were analyzed in 74 confirmed severe COVID-19 patients admitted to the intensive care unit of Farabi University Hospital, Kermanshah, Western Iran.
Results: Around 42% of patients had abnormal prothrombin time (PT) and international normalized ratio (INR). The rate of abnormal coagulation parameters in the mean age 76.6±7.7 and 46.6±10.3 years were 62 and 38%, respectively. Patients with comorbidities had significantly longer PT and higher INR that increased the rate of mortality to around 77% in these individuals. The abnormal pattern of coagulation parameters was highly associated with comorbidities and poor prognosis.
Conclusions: Our study demonstrated abnormal coagulation parameters and a high rate of coagulopathy in hospitalized patients with COVID-19 that was associated with age, comorbidities and mortality which should be considered in management of these patients.
Keywords
COVID-19, coagulation, prothrombin time, international normalized ratio, D-dimer
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This is a preprint. It has not completed peer review.
Short Report
Blood Coagulation Parameters in Patients with Severe COVID-19
Zohreh Rahimi
Kermanshah University of Medical Sciences, Kermanshah, Iran
Corresponding Author
ORCiD: https://orcid.org/0000-0001-7589-3307
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
History
CURRENT STATUS: Posted
Version 1
Posted 09 Jun, 2020
No community comments so far
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Hematology
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: Infection with coronavirus disease 2019 (COVID-19) could be complicated with coagulopathy and high risk of thromboembolic events.
Methods: Coagulation parameters were analyzed in 74 confirmed severe COVID-19 patients admitted to the intensive care unit of Farabi University Hospital, Kermanshah, Western Iran.
Results: Around 42% of patients had abnormal prothrombin time (PT) and international normalized ratio (INR). The rate of abnormal coagulation parameters in the mean age 76.6±7.7 and 46.6±10.3 years were 62 and 38%, respectively. Patients with comorbidities had significantly longer PT and higher INR that increased the rate of mortality to around 77% in these individuals. The abnormal pattern of coagulation parameters was highly associated with comorbidities and poor prognosis.
Conclusions: Our study demonstrated abnormal coagulation parameters and a high rate of coagulopathy in hospitalized patients with COVID-19 that was associated with age, comorbidities and mortality which should be considered in management of these patients.