Blood Coagulation Parameters in Patients with Severe COVID-19
Background: Infection with coronavirus disease 2019 (COVID-19) could be complicated with coagulopathy and high risk of thromboembolic events.
Methods: Coagulation parameters were analyzed in 74 confirmed severe COVID-19 patients admitted to the intensive care unit of Farabi University Hospital, Kermanshah, Western Iran.
Results: Around 42% of patients had abnormal prothrombin time (PT) and international normalized ratio (INR). The rate of abnormal coagulation parameters in the mean age 76.6±7.7 and 46.6±10.3 years were 62 and 38%, respectively. Patients with comorbidities had significantly longer PT and higher INR that increased the rate of mortality to around 77% in these individuals. The abnormal pattern of coagulation parameters was highly associated with comorbidities and poor prognosis.
Conclusions: Our study demonstrated abnormal coagulation parameters and a high rate of coagulopathy in hospitalized patients with COVID-19 that was associated with age, comorbidities and mortality which should be considered in management of these patients.
Posted 09 Jun, 2020
Blood Coagulation Parameters in Patients with Severe COVID-19
Posted 09 Jun, 2020
Background: Infection with coronavirus disease 2019 (COVID-19) could be complicated with coagulopathy and high risk of thromboembolic events.
Methods: Coagulation parameters were analyzed in 74 confirmed severe COVID-19 patients admitted to the intensive care unit of Farabi University Hospital, Kermanshah, Western Iran.
Results: Around 42% of patients had abnormal prothrombin time (PT) and international normalized ratio (INR). The rate of abnormal coagulation parameters in the mean age 76.6±7.7 and 46.6±10.3 years were 62 and 38%, respectively. Patients with comorbidities had significantly longer PT and higher INR that increased the rate of mortality to around 77% in these individuals. The abnormal pattern of coagulation parameters was highly associated with comorbidities and poor prognosis.
Conclusions: Our study demonstrated abnormal coagulation parameters and a high rate of coagulopathy in hospitalized patients with COVID-19 that was associated with age, comorbidities and mortality which should be considered in management of these patients.