Opportunities and challenges to Integrating mental health into HIV programs in a Low- and Middle-Income Country: Insights from the Nigeria Implementation Science Alliance

doi:10.21203/rs.3.rs-33429/v2

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Opportunities and challenges to Integrating mental health into HIV programs in a Low- and Middle-Income Country: Insights from the Nigeria Implementation Science Alliance

https://doi.org/10.21203/rs.3.rs-33429/v2

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published 29 Sep, 2020

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Background: In Nigeria, there is an estimated 1.9 million people living with HIV (PLHIV), 53% of whom utilize HIV care and services. With decreasing HIV-related deaths and increasing new infections, HIV with its associated comorbidities continue to be a key public health challenge in Nigeria. Untreated, comorbid mental disorders are a critical but potentially modifiable determinant of optimal HIV treatment outcomes. This study aimed to identify the challenges and opportunities related to integrating mental health care into existing HIV programs in Nigeria.

Method: Attendees at the Nigeria Implementation Science Alliance (NISA)’s 2019 conference participated in nominal group technique (NGT) exercise informed by the “Exploration, Preparation, Implementation, and Sustainment (EPIS)” framework. The NGT process was conducted among the nominal groups in two major sessions of 30-minutes phases followed by a 30-minute plenary session. Data analysis proceeded in four steps: transcription, collation, theming and content analysis.

Results: The two major theoretical themes from the study were – opportunities and challenges of integrating mental health treatment into HIV services. Three sub-themes emerged on opportunities: building on health care facilities for HIV services (screening, counseling, task-sharing monitoring and evaluation frameworks) , utilizing existing human resources or workforce in HIV programs (in-service training and including mental health in education curriculum) and the role of social and cultural structures (leveraging existing community, traditional and faith-based infrastructures). Four sub-themes emerged for challenges: double burden of stigma and the problems of early detection (HIV and mental health stigma, lack of awareness) , existing policy gaps and structural challenges (fragmented health system) , limited human resources for mental health care in Nigeria (knowledge gap and burnout) and dearth of data/evidence for planning and action (research gaps) .

Conclusions: Potential for integrating treatments for mental disorders into HIV services exist in Nigeria. These include opportunities for clinicians’ training and capacity building as well as community partnerships. Multiple barriers and challenges such as stigma, policy and research gaps would need to be addressed to leverage these opportunities. Our findings serve as a useful guide for government agencies, policy makers and research organizations to address co-morbid mental disorders among PLHIV in Nigeria.

Health Policy

Health Economics & Outcomes Research

Mental Health

Nigeria

Low and Middle-Income Countries

HIV

Mental Health Policy

Health services integration

Human immunodeficiency virus (HIV) infection has continued to be a global public health problem. Of the 37.9 million people living with HIV (PLHIV) globally, 70% reside in sub-Saharan Africa which has a disproportionate share of new infections (64%) and Acquired Immune Deficiency Syndrome (AIDS)-related deaths (61%)(1). In Nigeria, there is an estimated 1.9 million PLHIV, 53% of whom utilize HIV care and services(2, 3). AIDS-related deaths have decreased in Nigeria by 26% since 2010, and new infections have increased by 5%(3), thereby increasing the population of PLHIV. This increasing population of PLHIV suggests that HIV with its associated comorbidities will continue to be a key public health challenge in Nigeria in future years(4).

The link between HIV infection and mental disorders has been well established. PLHIV are three times more likely than the general population to have mental disorders (5). The psychosocial impact of HIV and neurologic complications of the infection or of treatment with antiretroviral drugs can increase the risk of mental disorders among PLHIV(6, 7). On the other hand, individuals with mental disorders are more likely to engage in risky behaviors which can predispose them to HIV infection and increase their chances of transmitting the virus(8). Depression is the most common mental disorder occurring among PLHIV with prevalence ranging from 9% to 32% in sub-Saharan Africa(5). In Nigeria, among PLHIV, the prevalence rate is 2.3% for suicide attempt, 2.9% for suicide ideation, 7% for alcohol abuse and 28.2% for major depression(9). Overall, the prevalence of mental disorders among PLHIV is higher than that of other chronic diseases(10). Mental disorders affect the HIV care continuum, including delayed initiation of antiretroviral treatment (ART), poor ART adherence(11) (12), poor retention in care(13), accelerated disease progression(14) and low rates of viral suppression. With these effects on the HIV cascade, untreated mental disorders are a critical but potentially modifiable determinant of optimal HIV treatment outcomes(15).

A meta-analysis of 29 studies showed that treatment of depression significantly improved ART adherence(16). A pilot study of depression treatment for PLHIV in Cameroon showed that all HIV clinical outcomes improved at 4 months after depression treatment(17). Yet, most people with mental disorders in Nigeria, including PLHIV, have little or no access to mental health treatment(18, 19). To address this barrier, a key recommendation of the International epidemiology Databases to Evaluate AIDS (IeDEA) consortium is the evaluation of promising models of integrated mental health and HIV care(20). Several integration models have been developed and tested for both HIV and non-HIV populations. Different integrative, task-sharing approaches involving lay health workers have been used to deliver antidepressants in Cameroon(17), to provide psychosocial interventions to PLHIV in South Africa(14), for problem solving therapy for depression and common mental disorders in Zimbabwe(21), and to improve lay health workers’ knowledge and self-efficacy in managing mental disorders in Malawi(22). The integrated care approach is a promising, acceptable and feasible strategy for improving both mental health and HIV treatment outcomes in low and middle-income countries (LMIC)(23-25). However these approaches to integrate HIV and mental health services remain limited by research gaps in cost-effectiveness and long-term impact of different models on patient outcomes and by barriers to their adoption in LMIC(25). Implementation scientists are well positioned to identify the challenges and opportunities in LMIC for integration of mental health services into existing HIV programs.

The Nigeria Implementation Science Alliance (NISA) was established in 2015 as a robust partnership of 20 organizations that includes academic and non-governmental organizations, clinical service providers, and policy makers involved in HIV care in Nigeria(26). NISA is aimed at facilitating collaboration among partners, bridging research-to-practice gaps through application of implementation science approaches and implementation research in Nigeria and other countries in Sub-Saharan Africa, and identifying feasible and culturally appropriate strategies for improving public health through research(26, 27). Yearly, NISA conferences have focused on “Prevention of mother to child HIV transmission(PMTCT)” (2015), “HIV/AIDS and related infections, adolescents health, STI & Hepatitis B” (2016), “Improving Health through Implementation Science & Research” (2017) and “Evidence-based approaches to enhance quality of care” (2018)(26-28). The fifth NISA conference in September 2019 focused on achieving impact through implementation research. It included a nominal group technique (NGT) session with researchers, policy makers, and program implementers focused on the opportunities and challenges for integrating mental health into HIV programs in Nigeria. In this paper, we present the challenges and opportunities identified through the NGT session related to integrating mental health care into existing HIV programs in Nigeria.

Process

We used a modified NGT approach to identify challenges and potential opportunities for integrating evidence-based mental health interventions into HIV services in Nigeria. Participants were drawn from attendees of the NISA 2019 conference and included program staff, researchers, government staff, administrators, donor community, and clinical caregivers. NGT is a structured approach for group “brainstorming”, and it is useful for gathering sets of ideas, information, or recommendations and their relative importance from relevant stakeholders (29, 30). The duration of the NGT process was 90 minutes and it was facilitated by five resource persons experienced in NGT(26, 28)

Before commencing the process, the lead facilitator introduced the topic to the participants and highlighted why it was an important public health issue. He stated the purpose of the research and also explained the modified NGT process that was adopted. The NGT process was conducted in two major 30-minute sessions, followed by a 30-minute plenary session. These three distinct components were designed to engage participants. In the first session, individual group members sequentially identified, discussed and ranked potential challenges and barriers to integrating mental health interventions into existing HIV clinical services and programs in Nigeria. This was followed by group discussion about the identified challenges and barriers. Then, the group voted and ranked these challenges and barriers in order of perceived importance. In the second session, individual group members identified, listed, discussed and ranked the opportunities and strategies for integrating mental health interventions into established HIV clinical services and programs. This was again followed by a group discussion of the lists, another round of voting, and ranking. In both sessions of the NGT process, the group members engaged in collective generation of ideas, discussion, consensus building, and ranking of the challenges of and opportunities for integrating mental health treatment into HIV services in Nigeria. For the plenary discussion, each group selected a lead and rapporteur to moderate and document the group exercise, respectively.

Analysis

Using a modified NGT analysis approach(31), the data analysis proceeded in four steps(32) Data from each of the nominal groups were individually transcribed and collated per group on Excel™ sheets. Then the multiple-group data was collated to provide the context and background for understanding the ranked-consensus data(33). The top five-ranked consensus items from each of the groups were then identified and sorted into themes. Within two major categories of (1) challenges with and (2) opportunities for integrating mental health treatment into HIV services, sub-themes were identified through the content analysis process. All data collection documents were de-identified prior to analysis. Ethical approval was obtained for this study from the National Health Research Ethics Committee. Verbal consent was obtained from the participants.

Eighty people participated in the NGT process, constituting 11 groups of 6-11 individuals per group. The participants included: 41 program staff, 13 researchers, 10 government staff, 9 administrators and 7 clinical caregivers. The majority of participants had been in their positions for at least five years (n=53) (Table 1).

Table 1: Role and experience of the NGT Participants

Job Role	Years of Experience	*n = 80*
Program staff	<5 5-10 >10 14 18 9	41


Administrator	4 3 2	9


Clinical Care	1 3 3	7


Government Staff	4 3 3	10


Researcher/Academic	4 6 3	13

There were a total of 105 ranked responses for both themes; 53 for opportunities and 52 for challenges. These responses were coalesced (Tables 2 and 3) according to ranking by the groups. Three sub-themes emerged from a content analysis of the ranked responses on the opportunities and four sub-themes emerged from a content analysis of the ranked responses for challenges (Table 4). These sub-themes are described below.

Table 2: Ranking of multi-group outputs of opportunities for integrating mental health services into HIV/AIDS care

Groups	Ranked List of Opportunities
Group 1	1. Integrating mental health care into existing HIV screening/testing and counselling 2. Including mental health outcomes into HIV/AIDS progress reports 3. Existing support groups, screening tools and data 4. Availability of National Task-shifting policy 5. Existing counselling session and psychosocial support on STIs, mental health 7. Existing human resource, infrastructure and services
Group 1
Group 2	1. School-based and in-service training of health workers 2. Including mental health integration to HIV/AIDS in funding proposals 3. Revision of existing HIV treatment policy to include mental health 4. Optimizing HIV training opportunities for mental health program 5. Existing policy in support of mental health 6. Existing skilled health workers (Doctors, nurses and counsellors). 7. Clinical evaluation of PLWHA Mental health assessment in HTS services
Group 3	1. Leveraging existing traditional and faith-based structures to create awareness on mental health 2. Using existing frameworks for monitoring and evaluation 3. Referrals from ART clinics to Mental Health Department and vice-versa
Group 4	1. Integrating 'mental health basic questions during routine patient care 2. Presence of established referral systems within and between facilities and mental health professionals 3. Engaging faith-based organizations and traditional leaders 4. Prior integration experience; available and provides evidence for integration of mental health intervention 5. Inclusion of mental health in the training curriculum of health workers 6. Existing commitment to HIV elimination 7. Existing support for HIV/Mental health awareness through community partners
Group 5	1. Screening for mental health during provision of ANC, PMTCT, Postpartum, Adolescent and Young Adult services 2. Services are available in one place 3. Growing awareness of mental health issues provides an opportunity for integration 4. Attraction for more research and program grants for mental health and HIV/AIDS 5. Support groups implementing mental health education into adolescent friendship centers
Group 6	1. Integrating mental health care into patient follow-up/tracking 2. Availability of adolescents and youth clubs in the communities aligned with HIV services

Table 3: Ranking of the multi-group outputs of challenges for integrating mental health services into HIV/AIDS care

Groups	Ranked List of Challenges
Group 1	1. Poor awareness of mental health by individuals, health care providers, and communities (including detection of early signs) 2. Double stigma' (HIV and Mental Health) 3. Absence of a National Health Policy on Mental Health in HIV/AIDS 4. Inadequate capacity and/or human resources for mental health care 5. Absence of policy on service integration, integrating mental health and HIV/AIDS
Group 2	1. Cultural beliefs about negative spiritual connotations of mental disorders 2. Poor funding for mental health services 3. Absence of national strategic plan on mental health issues, guidelines 4. Inadequate human resources for health care 5. Inadequate number of skilled health workers to offer mental health services 6. Sociocultural barriers like culture and religion 7. Lack of willingness of staff to take on mental health work
Group 3	1. Limited capacity and work overload for existing health workers 2. Difficulty in assessing mental health care in the existing system 3. Poor knowledge and skill of health care workers to provide mental health care services 4. Lack of government and donor support for mental health services 5. Poor social care system 6. Poor health-seeking behaviour on mental health issues 10. Knowledge gap from both health care providers and clients 11. Stigmatization of HIV patients
Group 4	1. Lack of structures/facilities for mental healthcare management 2. Fragmentation of different units and functions 3. Lack of mental health specific funding 5. Research gap in mental health 6. Affordability of mental health care
Group 5	1. Inadequate number of healthcare workers 2. Weak health systems to support mental health care 4. Data paucity for informed decision at the facility level 5. Lack of political will to implement policies 6. Lack/Inadequate policies/guidelines/protocols and guidelines for mental health 7. Getting the buy-in of policy makers 8. Cultural and religious beliefs about mental health
Group 6	1. High cost of mental health care

Table 4: Themes and sub-themes for integrating mental health care into HIV/AIDS care

Major themes

Sub-themes

Opportunities

1. Building on research and health care facilities for HIV services

2. Utilizing Existing Manpower

3. The role of social and cultural structures

Challenges

1. The Double Burden of Stigma and the Problems of Early Detection

2. Existing Policy Gaps and structural challenges

3. Poor Human Resources for Mental Health Care in Nigeria

4. Dearth of Research for Data and Action

Sub-themes on opportunities for integrating mental health care into HIV/AIDS Services

Building on health care facilities for HIV services

There was consensus on the robustness of existing structures around HIV/AIDS services that can be leveraged to integrate mental health care for PLHIV. Specifically, participants identified the HIV pre-test screening/testing counselling process, the task-shifting approach, the existing health screening tools, clinic counselling and mental health assessment during ART clinics as opportunities for leveraging existing HIV services framework for integrating mental health treatment. The existing Monitoring and Evaluation (M&E) frameworks for HIV care in Nigeria were also perceived by participants as potentially useful for assessing effectiveness of any integration of mental health care into HIV services for PLHIV.

Utilizing Existing Human Resources or Workforce in HIV programs

Participants believed that existing human resources for HIV services provide an opportunity for mental health capacity building. This can be achieved through in-service training for HIV health workers, inclusion of mental health care in the training curriculum of health workers and focusing on beneficial impact of mental health treatment on HIV outcomes like improved treatment retention, adherence and viral load suppression among PLHIV.

The role of social and cultural structures

Another sub-theme that was identified was the potential for leveraging existing traditional and faith-based infrastructures to create awareness about mental health. This can be achieved through community support groups aligned with these faith-based organizations and traditional leaders. Participants believed that these community support groups can work effectively with HIV service providers and their implementing partners to increase mental health awareness among PLHIV. Support groups can also provide education about mental health in adolescent friendship centers that already serve PLHIV. Furthermore, access to mental health care for PLHIV could be improved if social and cultural structures functioned alongside a hypothetically integrated referral system, from ART clinics to existing mental health services.

Sub-themes on challenges with integrating mental health care into HIV/AIDS Services

The Double Burden of Stigma and the Problems of Early Detection

Participants agreed that stigma thrives on poor awareness and that for PLHIV who experience mental disorders, there is the double burden of stigma arising from HIV and mental illness. Additionally, participants reported that stigma occurs among PLHIV, health care providers and communities with a culturally driven belief and negative spiritual connotation associated with mental illness. Thus, there is poor mental health awareness among both health care providers and patients leading to challenges with detecting early signs of mental illness among PLHIV and poor-health seeking behavior.

Existing Policy Gaps and structural challenges

A sub-theme emerged around policy gaps in integrating mental health care into HIV services in Nigeria. Participants identified the absence of service integration plans, national health policy on mental health, national strategic plan on mental health and guideline for monitoring and evaluation tools as major policy gaps posing challenges to integrating mental health into HIV services. The participants also believed that the existing structures for mental health in Nigeria are insufficient for the established need for mental health care. The operation and organization of mental health care within Nigeria's current health system are fragmented (operate at only the secondary and tertiary levels of care) and this limits the integration of mental health care into the existing HIV/AIDS care structure (which starts from the primary care level).

Limited Human Resources for Mental Health Care in Nigeria

Participants identified excessive workload for healthcare workers and scarcity of mental health specialists as potential challenges to integrating mental health care into HIV programs. There was also a perceived knowledge gap among care providers related to mental health that reduces their willingness to take on mental health work. Furthermore, participants believed that there is burn-out associated with working in mental health care due to understaffing.

Dearth of data/evidence for planning and action

Finally, a fourth sub-theme emerged about research gaps in mental health in Nigeria. Participants believed that this was a result of poor funding for research in mental health and for infrastructure. These research gaps lead to limited data that can inform the design and implementation of mental health policies, programs and actions.

This NGT exercise with key stakeholders in HIV services in Nigeria and the subsequent analysis identified seven key sub-themes regarding challenges to and opportunities for integrating mental health treatment into existing HIV services for PLHIV in Nigeria. Themes identified can readily be organized in accordance with the Exploration, Preparation, Implementation, and Sustainment (EPIS) framework(34, 35). There were three themes that emerged for opportunities (Building on research and health care facilities for HIV services, Utilizing existing workforce and leveraging social and cultural structures). Building on existing service infrastructure and service workforce such as primary health care centers, community youth organizations and faith-based institutions, invokes the EPIS construct of inner organizational context while social and cultural structures are represented in outer context at the country or region level. This finding is important not only for the potential for integrating mental health into HIV programs, but also highlights the feasibility of scale-up and sustainability. Some of these structures are already connected to HIV services infrastructure, and are very widely spread across Nigeria both in rural and urban settings(36, 37). Four themes were identified relating to challenges and barriers to such integration (The double burden of HIV and mental health stigma and the problems of early detection, existing health policy gaps and structural challenges, poor human resources for mental health care in Nigeria and dearth of research for data and action). Issues of stigma and health policy fall within the EPIS outer context domain while early detection and human resources are typically in the inner context domain. These themes reflect cultural and structural barriers that generally affect health care in Nigeria. They also highlight the need to focus on community engagement, public education, and advocacy as part of any intervention geared towards integration of mental health treatments into community HIV programs(38). These opportunities and challenges may be better understood in the context of the overall healthcare environment in Nigeria (underfunded, under-resourced and poorly developed), the nature of public-private partnerships that promote health research, sustainability of donor-driven program implementation, and the structure of research frameworks established by existing legislation (39). Utilizing implementation science frameworks such as EPIS can help organize and consider implementation barriers, facilitators, determinants, mechanisms, and outcomes in outer and inner contexts and the mechanisms that bridge these contexts such as leadership, policies, collaborations, community-academic partnerships and funding(35, 40).

This study involved multi-disciplinary groups of frontline staff, administrators, researchers, and clinicians with at least five years’ experience working in HIV programs and services in Nigeria. Thus, their perceptions and experiences are relevant to understanding these potential opportunities and barriers to integrating mental health treatments into HIV programs. Further, the varied perspectives and NGT process allowed for representation of EPIS implementation factors including outer context, inner context, bridging factors, interorganizational relationships, and innovation characteristics. Based on self-reported roles, most participants had direct knowledge and experience about the context of HIV care, services and program implementation in Nigeria. They also understood the role of government and funding agencies, the policy framework supporting the programs and the funding streams available in Nigeria for healthcare research. In addition, utilizing the multi-disciplinary group of professionals facilitated meaningful brainstorming from multiple perspectives and the generation of practical ideas.

Integrating mental health into primary health care and other non-specialty health settings is the bedrock of Nigeria’s policy on mental health access(41). Unfortunately, due to inadequate funding, limited mental health specialists and lack of legislative framework, this stated policy has not translated into state or federal laws or clinical practice(42). This may explain the perception by participants of lack of policy frameworks for integrating interventions for mental disorders into HIV services. However, there are existing, established tools and frameworks for integrating mental health into non-psychiatric settings using evidence-based task-sharing approaches such as the World Health Organization (WHO)’s mental health gap action plan (mhGAP)(43). The mhGAP has already been contextualized and tested in Nigeria(44, 45). Given the potential for integration of mental health treatments within HIV programs identified in this study and the availability of standardized, validated tools for such integration, efforts should be geared towards pilot implementation studies to explore the feasibility and effectiveness of mental health treatments integrated into HIV programs and services. NISA’s collaborating organizations and partner government agencies (the Federal Ministry of Health, the National Primary Healthcare Development Agency, and the National Agency for the Control of AIDS) can play a pioneering role in leveraging their relationships, academic partnerships, and funding agencies towards this goal(26, 28).

As identified by participants in this study, stigmatizing beliefs and negative attitudes towards HIV and mental disorders are a major barrier to accessing both mental health and HIV treatments(46, 47). There is evidence that collaboration between relevant government agencies in Nigeria and local and international non-governmental organizations to develop and implement strategic communication programs helped reduce HIV-related stigma. Exposure to HIV-related communication in the media increased knowledge about HIV and reduced negative attitudes towards people living with HIV(48). Lessons from such strategy around HIV and HIV-related services can be adapted and included in the design of interventions to integrate mental health treatments into HIV services.

There are limitations of this study that are worth noting. Firstly, the conference was open to staff from all HIV programs in Nigeria but participation was limited to those who were able to pay the required registration fees and available to attend at the conference dates and times. Secondly, the design and format of the NGT exercise, unlike a free-flowing focus group, is rigid and time-limited. To address this limitation, participants were grouped to include a mix of experiences, roles, and educational levels thereby ensuring that the perspectives, ideas and emergent consensus were as representative as possible. Thirdly, as in other group participation-based research, participants’ opinions and ideas may have been influenced by others in the group. To reduce the impact of this group factor, we utilized many small groups instead of few larger groups and identified moderators for each group who ensured that each individual member contributed adequately to the group discussions(49). Finally, data collection, collation, and analyses were conducted by the authors. This may inadvertently lead to the infusion of the authors’ perspectives in interpreting the data. To address this, we have included authors with varying backgrounds and experiences to ensure balanced perspectives in the analysis and interpretation of the results(50)

Potential for integrating treatments for mental disorders into HIV programs and services exist in Nigeria. These include opportunities for clinicians’ training and capacity building as well as community partnerships. Multiple barriers and challenges such as funding, stigma and policy gaps would need to be addressed to leverage these opportunities. The subthemes that emerged from this study reflect the on-the-ground experiences, practical realities and collective wisdom of professionals involved in HIV programs and services in Nigeria. Our findings serve as a useful guide for government agencies, policy makers, research organizations and local foundations in Nigeria to address co-morbid mental disorders among PLHIV in Nigeria.

HIV = Human Immunodeficiency Virus

PLHIV = People Living with HIV

AIDS = Acquired Immune Deficiency Syndrome

ART = Antiretroviral treatment

LMIC = Low and middle-income countries

NISA = Nigeria Implementation Science Alliance

NGT = Nominal Group Technique

EPIS = Exploration, Preparation, Implementation, and Sustainment

WHO = World Health Organization

mnGAP = mental health Gap Action Plan

Ethics approval and consent to participate: Ethical approval was obtained for this study from the National Health Research Ethics Committee. Verbal consent was obtained from the participants.

Consent for publication: Not applicable

Availability of data and materials: All the data generated and/or analysed during this study are included in this published article.

Competing interests: The authors declare that they have no competing interests

Funding: There is no grant support for this study

Authors contributions: All authors contributed to the study design, implementation, analysis, manuscript preparation, editing and revisions. All authors read and approved the final manuscript.

Acknowledgement: The authors wish to thank the Nigeria Implementation Science Alliance (NISA) and all of it’s affiliate members, partners and collaborators for their participation in this study. The information provided in this paper is not official Government information and does not represent the views or positions of the U.S. Agency for International Development, Centers for Disease Control and Prevention, National Institute of Health, the Nigerian Government or the U.S. Government.

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Opportunities and challenges to Integrating mental health into HIV programs in a Low- and Middle-Income Country: Insights from the Nigeria Implementation Science Alliance

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