This preprint is under consideration at BMC Anesthesiology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
The Effect of Preoperative Anxiety Level on Mean Platelet Volume and Propofol Consumption
ali ihsan uysal
University of Muğla Training and Research Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3320-4558
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The mean platelet volume (MPV) is an important indicator of platelet function with large platelets showing higher enzymatic and metabolic activity than other platelets. There can be a relationship between increased platelet activity and anxiety and depression. Our primary hypothesis was that patients with high anxiety scores would have higher MPV, and the secondary hypothesis was that propofol induction time and total propofol consumption within the first 30 min of surgery would be higher in patients with higher anxiety scores. Methods: The Beck Anxiety Inventory (BAI) was administered to the participating patients one day before surgery to evaluate the level of anxiety. Based on the scores from the BAI, 40 patients with an anxiety score of <8 were assigned to the non-anxious group (Group NA) and 40 patients with an anxiety score of ³8 were assigned to the anxious group (Group A). At the anesthesia induction the mean time to achieve an entropy value below 60 (T1) was recorded. The total intraoperative propofol consumption within the first 30 min was recorded. Results: There was a statistically significant difference between the groups in terms of preoperative MPV and demographic data, including age and sex. The mean total propofol consumption at 30 min after induction in the groups was statistically significant. The cut-off value for MPV was calculated as 9.65. Conclusions: The preoperative MPV values and propofol consumption at 30 minutes among patients with high preoperative anxiety scores were high. We suggest that MPV is helpful in the clinical practice in predicting the amount of anesthetic agents required for the induction of anesthesia.
Figure 1
Figure 2
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 3
Posted 14 Jan, 2020
No community comments so far
Review #1 received
Received 22 Jan, 2020
Reviewer #1 agreed
On 15 Jan, 2020
Reviewers invited
Invitations sent on 15 Jan, 2020
Editor assigned
On 10 Jan, 2020
Submission checks complete
On 09 Jan, 2020
Editor invited
On 09 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 03 Jan, 2020
Review #1 received
Received 17 Dec, 2019
Reviewer #1 agreed
On 13 Dec, 2019
Reviewers invited
Invitations sent on 19 Nov, 2019
Editor assigned
On 29 Oct, 2019
Submission checks complete
On 28 Oct, 2019
Editor invited
On 28 Oct, 2019
No comments provided
Editorial decision: Major revision
On 10 Sep, 2019
Review #2 received
Received 30 Aug, 2019
Review #1 received
Received 21 Aug, 2019
Reviewer #2 agreed
On 12 Aug, 2019
Reviewer #1 agreed
On 03 May, 2019
Reviewers invited
Invitations sent on 08 Mar, 2019
Editor assigned
On 19 Feb, 2019
Submission checks complete
On 14 Feb, 2019
Editor invited
On 14 Feb, 2019
First submitted
On 31 Jan, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Internal Medicine Specialties
Learn more about our company.
This preprint is under consideration at BMC Anesthesiology. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
The Effect of Preoperative Anxiety Level on Mean Platelet Volume and Propofol Consumption
ali ihsan uysal
University of Muğla Training and Research Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0002-3320-4558
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Under Review
Version 3
Posted 14 Jan, 2020
No community comments so far
Review #1 received
Received 22 Jan, 2020
Reviewer #1 agreed
On 15 Jan, 2020
Reviewers invited
Invitations sent on 15 Jan, 2020
Editor assigned
On 10 Jan, 2020
Submission checks complete
On 09 Jan, 2020
Editor invited
On 09 Jan, 2020
No comments provided
Editorial decision: Minor revision
On 03 Jan, 2020
Review #1 received
Received 17 Dec, 2019
Reviewer #1 agreed
On 13 Dec, 2019
Reviewers invited
Invitations sent on 19 Nov, 2019
Editor assigned
On 29 Oct, 2019
Submission checks complete
On 28 Oct, 2019
Editor invited
On 28 Oct, 2019
No comments provided
Editorial decision: Major revision
On 10 Sep, 2019
Review #2 received
Received 30 Aug, 2019
Review #1 received
Received 21 Aug, 2019
Reviewer #2 agreed
On 12 Aug, 2019
Reviewer #1 agreed
On 03 May, 2019
Reviewers invited
Invitations sent on 08 Mar, 2019
Editor assigned
On 19 Feb, 2019
Submission checks complete
On 14 Feb, 2019
Editor invited
On 14 Feb, 2019
First submitted
On 31 Jan, 2019
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
Subject Areas
Internal Medicine Specialties
License:
This work is licensed under a CC BY 4.0 License. Read Full License
Background: The mean platelet volume (MPV) is an important indicator of platelet function with large platelets showing higher enzymatic and metabolic activity than other platelets. There can be a relationship between increased platelet activity and anxiety and depression. Our primary hypothesis was that patients with high anxiety scores would have higher MPV, and the secondary hypothesis was that propofol induction time and total propofol consumption within the first 30 min of surgery would be higher in patients with higher anxiety scores. Methods: The Beck Anxiety Inventory (BAI) was administered to the participating patients one day before surgery to evaluate the level of anxiety. Based on the scores from the BAI, 40 patients with an anxiety score of <8 were assigned to the non-anxious group (Group NA) and 40 patients with an anxiety score of ³8 were assigned to the anxious group (Group A). At the anesthesia induction the mean time to achieve an entropy value below 60 (T1) was recorded. The total intraoperative propofol consumption within the first 30 min was recorded. Results: There was a statistically significant difference between the groups in terms of preoperative MPV and demographic data, including age and sex. The mean total propofol consumption at 30 min after induction in the groups was statistically significant. The cut-off value for MPV was calculated as 9.65. Conclusions: The preoperative MPV values and propofol consumption at 30 minutes among patients with high preoperative anxiety scores were high. We suggest that MPV is helpful in the clinical practice in predicting the amount of anesthetic agents required for the induction of anesthesia.
Figure 1
Figure 2