ReactomePathway
|
p-value
|
FDR
|
Hit Genes
|
Laminin interactions
|
3,33E-16
|
1,67E-13
|
HSPG2,COL18A1,ITGB4,ITGA7,LAMA5,LAMA2,LAMA1,LAMA4,LAMA3,LAMB3,LAMB1
|
Collagen formation
|
9,19E-14
|
2,30E-11
|
COL12A1,COL17A1,COL5A1,COL18A1,ITGB4,COL10A1,COL2A1,COL6A2,COL6A1,COL11A1,LAMA3,COL11A2,LAMB3,COL7A1
|
Assembly of collagen fibrils and other multimeric structures
|
1,82E-13
|
3,04E-11
|
COL5A1,COL18A1,ITGB4,COL10A1,COL2A1,COL6A2,COL6A1,COL11A1,LAMA3,COL11A2,LAMB3,COL7A1
|
Collagen chain trimerization
|
3,11E-13
|
3,89E-11
|
COL12A1,COL17A1,COL5A1,COL18A1,COL10A1,COL2A1,COL6A2,COL6A1,COL11A1,COL11A2,COL7A1
|
Non-integrin membrane-ECM interactions
|
6,24E-12
|
6,24E-10
|
TNC,HSPG2,ITGB4,LAMA5,LAMA2,LAMA1,LAMA4,LAMA3,LAMB3,LAMB1
|
Collagen biosynthesis and modifying enzymes
|
2,69E-11
|
2,23E-09
|
COL12A1,COL17A1,COL5A1,COL18A1,COL10A1,COL2A1,COL6A2,COL6A1,COL11A1,COL11A2,COL7A1
|
ECM proteoglycans
|
1,00E-10
|
7,11E-09
|
TNC,HSPG2,ITGA7,LAMA5,TNXB,LAMA2,LAMA1,LAMA4,LAMA3,LAMB1
|
MET activates PTK2 signaling
|
3,59E-10
|
2,23E-08
|
LAMA5,LAMA2,LAMA1,LAMA4,LAMA3,LAMB3,LAMB1
|
MET promotes cell motility
|
9,35E-09
|
5,15E-07
|
LAMA5,LAMA2,LAMA1,LAMA4,LAMA3,LAMB3,LAMB1
|
Degradation of the extracellular matrix
|
7,08E-07
|
3,54E-05
|
COL12A1,HSPG2,COL17A1,COL18A1,MMP2,LAMA5,LAMA3,LAMB3,LAMB1
|
Type I hemidesmosome assembly
|
1,47E-06
|
6,62E-05
|
COL17A1,ITGB4,LAMA3,LAMB3
|
Signaling by MET
|
2,50E-06
|
1,03E-04
|
LAMA5,LAMA2,LAMA1,LAMA4,LAMA3,LAMB3,LAMB1
|
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
|
1,57E-05
|
5,95E-04
|
TNC,APOB,FN1,SERPINA1,PCSK9,MMP2,F5,LAMB1
|
Platelet degranulation
|
1,96E-05
|
6,62E-04
|
PROS1,F13A1,FN1,SERPINA1,VWF,F5,TTN,FLNA
|
Platelet activation, signaling and aggregation
|
2,01E-05
|
6,62E-04
|
PROS1,F13A1,FN1,GP6,SERPINA1,VWF,GP1BA,F5,TTN,GNA14,FLNA
|
NCAM1 interactions
|
2,16E-05
|
6,70E-04
|
CACNA1D,CACNA1H,CACNA1S,COL6A2,COL6A1
|
Response to elevated platelet cytosolic Ca2+
|
2,57E-05
|
7,46E-04
|
PROS1,F13A1,FN1,SERPINA1,VWF,F5,TTN,FLNA
|
Formation of Fibrin Clot (Clotting Cascade)
|
2,78E-05
|
7,49E-04
|
PROS1,F13A1,VWF,GP1BA,F5
|
Integrin cell surface interactions
|
2,92E-05
|
7,59E-04
|
TNC,HSPG2,FN1,COL18A1,ITGB2,ITGA7
|
L1CAM interactions
|
3,26E-05
|
8,16E-04
|
ANK2,ANK3,ANK1,KCNQ2,RDX,LAMA1,LAMB1
|
Anchoring fibril formation
|
3,65E-05
|
8,40E-04
|
LAMA3,LAMB3,COL7A1
|
Post-translational protein phosphorylation
|
4,98E-05
|
1,10E-03
|
TNC,APOB,FN1,SERPINA1,PCSK9,F5,LAMB1
|
Terminal pathway of complement
|
5,41E-05
|
1,14E-03
|
C5,C7,C8B
|
Interleukin-4 and Interleukin-13 signaling
|
6,62E-05
|
1,32E-03
|
F13A1,SOCS1,FN1,ITGB2,MMP2,LAMA5,POMC
|
GP1b-IX-V activation signaling
|
1,04E-04
|
2,09E-03
|
VWF,GP1BA,FLNA
|
Nervous system development
|
1,24E-04
|
2,35E-03
|
ANK2,ANK3,ANK1,KCNQ2,CACNA1D,CACNA1H,MYH11,CACNA1S,RDX,MMP2,COL6A2,COL6A1,LAMA2,LAMA1,LAMB1
|
Interaction between L1 and Ankyrins
|
1,39E-04
|
2,39E-03
|
ANK2,ANK3,ANK1,KCNQ2
|
Cell junction organization
|
1,40E-04
|
2,39E-03
|
COL17A1,ITGB4,LAMA3,FLNA,FLNC,LAMB3
|
NCAM signaling for neurite out-growth
|
1,77E-04
|
3,01E-03
|
CACNA1D,CACNA1H,CACNA1S,COL6A2,COL6A1
|
Platelet Adhesion to exposed collagen
|
2,25E-04
|
3,60E-03
|
GP6,VWF,GP1BA
|
Axon guidance
|
2,65E-04
|
4,24E-03
|
ANK2,ANK3,ANK1,KCNQ2,CACNA1D,CACNA1H,MYH11,CACNA1S,RDX,MMP2,COL6A2,COL6A1,LAMA1,LAMB1
|
HDR through Single Strand Annealing (SSA)
|
3,48E-04
|
5,22E-03
|
BRIP1,ATM,ATR,RBBP8
|
Presynaptic phase of homologous DNA pairing and strand exchange
|
4,24E-04
|
6,35E-03
|
BRIP1,ATM,ATR,RBBP8
|
Collagen degradation
|
4,66E-04
|
6,52E-03
|
COL12A1,COL17A1,COL18A1,MMP2
|
Signaling by Receptor Tyrosine Kinases
|
5,41E-04
|
7,26E-03
|
PPP2R1B,SOCS1,ATP6V0A4,COL6A2,COL6A1,LAMA5,LAMA2,LAMA1,LAMA4,LAMA3,ERBB3,LAMB3,LAMB1
|
Homologous DNA Pairing and Strand Exchange
|
5,58E-04
|
7,26E-03
|
BRIP1,ATM,ATR,RBBP8
|
Regulation of TP53 Activity
|
5,71E-04
|
7,42E-03
|
PPP2R1B,BRIP1,ATM,ATR,TBP,RBBP8,CDKN2A
|
LDL clearance
|
6,76E-04
|
8,79E-03
|
APOB,PCSK9,LDLRAP1
|