Age affects lateral spurring after pediatric humerus lateral condyle fractures: A retrospective cohort study Authorship

doi:10.21203/rs.3.rs-3417877/v1

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Age affects lateral spurring after pediatric humerus lateral condyle fractures: A retrospective cohort study Authorship

https://doi.org/10.21203/rs.3.rs-3417877/v1

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Background:

Lateral spurring is frequently observed after lateral condyle fractures of the humerus in children. Despite its frequent recognition, few previous studies have defined this phenomenon, explored a correlation with any fracture or treatment characteristics, nor assessed its clinical significance.

Methods:

Information of 146 lateral condyle fractures in children from June 2015 to September 2021 were retrospectively analyzed and an database was established. Lateral spurring was defined as a bony overgrowth over the lateral aspect of the lateral condyle resulting in imaging irregularity on radiography. Univariable and multivariable logistic regression analyses were used to identify independent risk factors for lateral spurring, and a receiver operating characteristic (ROC) curve was used to assess the impact of independent risk factors.

Results:

Among the 146 fractures identified, 6.6% were treated with cast immobilization, 93.4% with open reduction and internal fixation, and none with closed reduction and percutaneous pinning. In total, 110(75.3%) patients developed a lateral spur, age was identified as an independent risk factor for lateral spurring(P<0.001), and the area under the ROC curve (AUC) was 0.806(95% confidence interval [CI] 0.729-0.883, P<0.001). At age 61.5 months, the Youden index reached its maximum with a sensitivity of 86.1% and specificity of 65.5%, Patients with age less than 61.5 months had a higher lateral spurring, the Relative Prevalence (RP) was 1.70.

Conclusions:

The development of lateral spurring closely correlates with patient age, the incidence of lateral spurring decreases with age, the incidence of lateral spurring was higher in patients younger than 61.5 months. The presence of a lateral spur after an LCF of the humerus does not influence the function or the appearance of the elbow.

Level of Evidence:

Level Ⅳ— retrospective study.

lateral

condyle

fracture

spur

pediatric

Lateral condyle fractures (LCFs) are the second most common pediatric fractures and comprise 12–20% of all pediatric upper extremity fractures(1). These fractures most commonly occur in children 4 to 10 years of age, with the highest incidence in children 6 years of age, and have been widely concerned because of their complicated complications(1, 2). Nondisplaced pediatric LCFs are often treated with cast immobilization, however, displaced fractures often need surgical treatment to reduce the incidence of complications, such as nonunion, deformity, and arthritis(3, 4). Depending on the classification and the amount of displacement of pediatric LCFs, closed reduction with percutaneous pinning (CRPP) or open reduction with internal fixation (ORIF) will be applied.

The outcome of pediatric LCFs has been extensively discussed in the literature(5, 6). However, as the most common complication of LCFs, a “lateral spur”, has seldom been investigated(2, 7, 8), it has been described as a bony overgrowth over the lateral of the distal humerus after the healing of pediatric LCFs. The formation of the lateral spur often occurs as the result of bone healing, about 2–6 weeks after the fracture(9). A “lateral spur” is not only a radiographic phenomenon, but also a clinical finding as well, as it is often palpable and thus frequently noted by patients, parents and physicians, inducing wide concern(2, 10).

Our study aimed to identify the potential risk factors for lateral spurring by analyzing data that have been collected retrospectively as part of an ongoing Institutional Review Board-approved data-collection project on pediatric elbow fractures. If the risk factors can be identified, their influence to the occurrence of lateral spurring will be assessed by statistical analysis. Moreover, whether lateral spurring has an effect to the appearance or function of the elbow will be clarified. By probing into lateral spurring, we aim to better the phenomenon of lateral spurring and provide information for physicians to better educate patients and families.

Patient selection

From June 2015 to September 2021, the clinical data of LCFs patients younger than 15 years of age admitted to our hospital were collected and a database was established as part of an Institutional Review Board-approved study on pediatric elbow fractures. The patient’s inclusion was based on radiographic diagnosis. All elbows were evaluated with standard AP and lateral radiographs, performed by experienced technicians and uploaded into our digital radiology package (INFINITT PACS V 3.0.10.2 BN3 20100614; INFINITT Healthcare Co., Ltd). All radiographs were taken at a fixed distance of 3.61 inches using the same digital x-ray machine (DigitalDiagnost DiDiEleva01 2.1.4v22.13.567, PHILIPS).

Parameter selection

The clinical characteristics of all patients were obtained from their medical records. The characteristics of interest included age, sex, body mass index (BMI), side of injury, initial displacement, type of treatment, type of fracture, delayed fracture (injury > 2 weeks) or not, combined with other elbow injury or not, the Mayo elbow performance score (MEPS)(11), range of motion (ROM) loss, and complications. Fracture initial displacement < 2 mm, between 2–4 mm and > 4 mm. All of the fractures were Milch type 2, so only Jacob fracture type were adopted(5). ROM loss was divided into 4 degrees: <15° ROM loss was defined as mild elbow mobility disorder, 15°-30° ROM loss was moderate, 30°-50° ROM loss was severe, and > 50° ROM loss was extremely. MEPS was divided into 4 categories: a score > 90 was defined as excellent, 75–89 as good, 60–74 as medium, and < 60 as poor. Complications included cubitus varus, cubitus valgus, nonunion, fishtail deformity, avascular necrosis, incision infection, and subjective lateral prominence. By measuring the elbow carrying angle in the anteroposterior (AP) radiograph, carrying angles less than − 5° or greater than 15° were defined as cubitus varus or cubitus valgus, respectively. Information on subjective lateral prominence was obtained by telephone follow-up, and the patient's parents were asked whether a lateral prominence could be seen by general appearance.

Treatment method

The type of treatment was decided by the fractures’ initial displacement(9). The greatest distance between the two fragments on any single view of AP and lateral radiograph was measured and documented as the initial displacement. Conservative treatment with long-arm immobilization was used for fractures displaced by < 2 mm. A closed reduction under anesthesia was attempted for fractures displaced between 2–4 mm. For fractures with an initial displacement > 4 mm and for those > 2 mm after closed reduction, ORIF was performed. All surgeries were performed by experienced surgeons using a standard lateral approach incision. Two Kirschner wires (1.5 mm diameter) were used for the fixation of fresh fractures, and a metal hollow screw (3.5 mm diameter) and a Kirschner wire were used for delayed fractures. All operative fractures used an ORIF. For fresh fractures, surgery was performed at a mean of 3.37 days after injury (range, 0 to 15 d); for delayed fractures, surgery was performed at a mean of 31.67 days after injury (range, 17 to 70 d).

A long arm cast was used for protection immediately after the surgery. The patients were re-evaluated in the clinic 4 weeks postoperatively. If the fracture was healing well and the patient was asymptomatic, the long arm cast was removed. After cast removal, active elbow motion was encouraged. ROM measurements and MEPS evaluation were performed through clinic and telephone follow-up.

Statistical analysis

Categorical and continuous baseline characteristics and perioperative variables are reported as the quantity, percentage, or median and interquartile range (IQR), as appropriate. Moreover, continuous variables were compared between two groups by Student’s t test or Mann–Whitney rank sum U tests, while categorical variables were compared by the chi-square test or Fisher’s exact test. After univariable logistic regression, only variables with P < 0.1 were submitted to multivariable analysis. A receiver operating characteristic (ROC) curve and the area under the ROC curve (AUC) were used to confirm the predictive ability of the risk factors for lateral spurring. Similar to previous studies, this research used the maximum sum of sensitivity and specificity as the best cut-of value. Relative risk (RR) was adopted to further assess the influence of the risk factors to the occurrence of lateral spurring.

All tests were 2-tailed, with a P value < 0.05 indicating significance. All statistical and graphical analyses were performed using SPSS version 26.0 (IBM SPSS Inc., Chicago, IL, USA).

In this retrospectively study, we reviewed the radiographs of 150 pediatric LCFs and found a high incidence of a lateral spur, defined as a bony overgrowth over the lateral of the distal humerus. 4 of the 150 cases are excluded because of insufficient follow-up (< 4 w). Therefore, 146 fractures were included in this study. Whether a lateral spur occurred was determined by reading the AP and lateral radiographs approximately half a year (5.19 months average, range, 2–6 months) after the injury.

Clinical characteristics

Of the 146 fractures included in the study, 110 (75.3%) developed a lateral spur, and 36 (24.7%) did not. In Table 1, there were 99 males (67.8%) and 47 females (32.2%) included in the study, with a mean age of 58.50 months (38.75–83.25 m), the clinic and telephone follow-up times were 7.59 months (range, 0–45 months) and 37.87 months (range, 0–91 months), respectively. Of the 146 fractures, 9 (6.2%) were treated with cast immobilization, and 137 (93.8%) were treated with ORIF. Of the 146 fractures, all were Milch type II fractures; 5 were Jacob type I fractures, 44 were Jacob type II fractures, and 97 were Jacob type III fractures. 19 fractures were combined with other elbow injuries (2 with humerus internal condylar fracture, 1 with fracture of proximal radius, 1 with dislocation of elbow joint, and 15 with fracture of proximal ulna). Regarding complications, 7 had cubitus varus (4.8%), 17 had cubitus valgus (11.6%), 1(0.01%) had nonunion, 4(2.7%) had incision infection, and 43(42.2%, only 102 cases had a telephone follow-up) developed a subjective lateral prominence, fishtail deformity or avascular necrosis were not observed. By telephone follow-up, the occurrence of a lateral spur and prominence of humeral lateral condyle did not show a correlation (P = 0.731).

Table 1

Clinical characteristics of recipients in different prealbumin levels
N%	Total (N = 146)	Lateral spurring (+)	Lateral spurring (-)	P value
Age, months^a	58.50(38.75–83.25)	51.00(34.75-72.00)	89.00(67.25–106.50)	< 0.001
Sex				0.809
Male	99	74	25
Female	47	36	11
BMI^a	17.56(15.41–19.52)	17.82(15.60-19.52)	17.09(15.38–19.40)	0.356
Side of injury				0.707
Right	65	48	17
Left	81	62	19
Jacob type				0.913
TypeⅠ	5	2	3
TypeⅡ	44	37	7
TypeⅢ	97	71	26
Initial displacement				0.449
< 2mm	27	17	10
2-4mm	39	33	6
> 4mm	80	60	20
Conservative or surgical				0.001
Conservative	9	7	2
Surgical	137	108	29
ROM loss				< 0.001
< 15°	134	105	29
15°-30°	2	1	1
30°-50°	2	0	2
> 50°	2	0	2
MEPS				0.001
Excellent	132	104	28
Good	4	3	1
Medium	3	1	2
Poor	1	0	1
Delayed fracture or not				0.279
Yes	17	11	6
No	129	99	30
Combined with other elbow injuries or not				0.014
Yes	19	10	9
No	127	100	27
Complications
Cubitus varus				1.000
Yes	17	13	4
No	129	97	32
Cubitus valgus				0.487
Yes	7	4	3
No	139	106	33
Nonunion				1.000
Yes	1	1	0
No	145	109	36
Fishtail deformity	0	0	0
Avascular necrosis	0	0	0
Incision infection				0.567
Yes	4	4	0
No	142	106	36
Subjective lateral prominence				0.731
Yes	43	30	13
No	59	43	16

Relationship between age and lateral spurring

As shown in Table 2, the clinical characteristics were included in the univariable logistic regression analysis, and the results showed that age, surgical treatment, ROM, MEPS and combined with other elbow injuries were significantly correlated with the incidence of lateral spurring. After multivariable adjustment, age at the time of admission was shown to be an independent predictive factor for lateral spurring. However, given that the amount of fracture displacement is directly correlated with the decision of whether or not to operate, surgical treatment should not be considered as an independent predictor for the development of lateral spurring; age at the time of admission was a protective independent factor for lateral spurring, (OR = 0.967; 95% confidence interval [CI] 0.952–0.983; P < 0.001).

Table 2

Univariate and multivariate analysis for predictors of postoperative complications
Variables	Univariable OR (95% CI)	Univariable P value	Multivariable OR (95% CI)	Multivariable P value
Age, months	0.965(0.951–0.980)	< 0.001	0.967(0.952–0.983)	< 0.001
Sex	1.106(0.490–2.494)	0.809
BMI	1.077(0.938–1.237)	0.292
Side of injury	0.865(0.407–1.841)	0.865
Jacob type	0.912(0.483–1.917)	0.912
Initial displacement	1.202(0.747–1.934)	0.448
Conservative or surgical	13.034(2.569–66.132)	0.002	10.677(1.453–78.470)	0.020
ROM	0.140(0.021–0.909)	0.039	0.359(0.030–4.240)	0.416
MEPS	0.236(0.075–0.745)	0.014	0.376(0.080–1.782)	0.218
Delayed fracture or not	0.556(0.190–1.628)	0.284
Combined with other elbow injuries or not	0.300(0.111–0.812)	0.018	0.934(0.210–4.151)	0.928
Cubitus varus	0.415(0.088–1.950)	0.265
Cubitus valgus	1.072(0.321–3.523)	0.909
Subjective lateral prominence	0.859(0.361–2.045)	0.731

ROC analysis was used to further investigate the relationship between age and lateral spurring. A cut-off value of 61.5 months calculated by ROC analysis was the optimal criterion, with a sensitivity of 86.1% and specificity of 65.5%, as shown in Fig. 2. For predicting lateral spurring after pediatric humerus lateral condyle fractures, the AUC of age was 0.806(95% [CI] 0.729–0.833; P < 0.001). The incidence of a lateral spur was 93.51% (72/77) and 55.07% (38/69) in patients group younger or older than 61.5 months, respectively, the Relative Prevalence (RP) was 1.70.

Lateral spurring is the most commonly seen complication after pediatric humerus lateral condyle fractures, with a distinct radiographic deformity. Although this phenomenon has been previously reported(2, 7, 8, 12–16), there are still questions remain that unanswered, including its relationship with a deformity in appearance, any possible effects on the overall function of the elbow, and risk factors for its occurrence.

Previous studies reported the presence of a lateral spur in approximately 70% of pediatric humerus lateral condyle fractures(2, 9, 13, 15). In our study, 75.3% of the patients subsequently developed a lateral spur, which is similar to the finding previously described. Pribaz et al. adopted the concept of “interepicondylar width” (IEW), assessed as the maximum distance between the medial and lateral epicondyles of the distal humerus both at the time of admission and at the final follow-up, to describe the severity of a lateral spur. However, we did not use the method because 6.4% (7/110) of the spurs were observed on the lateral radiographs instead of the AP radiograph. Moreover, it was difficult to standardize the appropriate measurement time considering the growth potential of children. Therefore, we did not quantify the severity of a lateral spur.

In our study, age was first found to be a protective independent factor against lateral spurring, the incidence of this complication decreased with age; moreover, patients with age less than 61.5 months were more prone to lateral spurring. This finding can be explained by the overgrowth phenomenon after children’s fractures, which has been observed after fractures of the femur, tibia, and humerus(17). Bone overgrowth following fracture occurs as a result of hyperemia of fracture healing, and the increased vascularity spreads to the epiphyseal plate leading to growth stimulation and overgrowth(18, 19). Premal Naik found that remodeling and overgrowth are most pronounced at the growing end of the bone and along the axis of the adjacent joint motion, especially in the case of hinge joints such as the elbow and knee(17). Additionally, an extreme example is, in fractures around the elbow, we found that a bony spur only appeared in pediatric patients. This phenomenon is consistent with Malkawi H et al’s research: bony overgrowth was most significant in the 3–9 year age group(20).

Our study once again demonstrated the fact that the presence of a lateral spur has almost no influence on the function of the elbow. Moreover, our study first found that the appearance of the elbow has no correlation with the occurrence of a lateral spur, and subjective lateral prominence seems to be correlated only with the overgrowth of the humerus lateral condyle instead of the spur. These findings will help physicians treating LCFs to reassure patients and families.

This study has several limitations. First, there are inherent limitations with radiographic techniques and results, especially regarding the measurement of the carrying angle. To minimize such limitations, we used standardized techniques performed by an experienced technician and up-to-date digital radiology software, and the patients were also well guided by the technician to obtain the most appropriate position. Additionally, there are no effective methods to quantify the severity of a lateral spur in our study. A lateral spur can be only qualitatively described but not quantitatively measured. In addition, limited by relatively backward treatment concepts, no CRPP was included in our cohort, although other study has proved that there is no significant difference between CRPP and ORIF in the occurrence of a lateral spur(9). Finally, the current consensus is that LCFs with displacement > 2 mm should receive surgical treatment, so surgical treatment still cannot be identified or excluded as an independent risk factor for lateral spurring.

In summary, our study established a database of pediatric patients with LCFs of the humerus to better understand the phenomenon of lateral spurring. As the most common complication after pediatric LCFs, our analysis found that the occurrence of lateral spurring is closely associated the age of patients, and the incidence of this complication decrease with age. Fortunately, the presence of a lateral spur after an LCF of the humerus does not seem to influence the function or appearance of the elbow.

Ethics approval and consent to participate

This study was approved by the ethics committee of the 96603 Military Hospital according to the principles of the Declaration of Helsinki. Written informed consent was waived by the institutional review board for the present study was retrospective.

Consent for publication

Not applicable.

Availability of data and materials

The datasets used and/or analyzed during the current study can be available from the corresponding author on reasonable request.

Competing interests

None declared.

Funding

The present work was unfunded.

Authors’ contributions

Conception: Nan Li, Tao Liu, Wu Wen, Chuan Dong. Study design: Nan Li. Administrative support: Saiping Han, Wei Zhou. Data collection and acquisition: Xing Yin, Yu Liu. Data analysis: Nan Li, Tao Liu. Manuscript preparation: Nan Li, Tao Liu, Wu Wen, Chuan Dong. Figures preparation: Xing Yin, Yu Liu,Wei Zhou. Critical revision: Xing Yin, Yu Liu, Saiping Han. All authors read and approved the final manuscript.

Acknowledgements

Not applicable.

Milch H. Fractures and Fracture Dislocations of the Humeral Condyles. J Trauma. 1964;4:592–607.
Koh KH, Seo SW, Kim KM, Shim JS. Clinical and radiographic results of lateral condylar fracture of distal humerus in children. J Pediatr Orthop. 2010;30(5):425–9.
Park H, Hwang JH, Kwon YU, Kim HW. Osteosynthesis in situ for lateral condyle nonunion in children. J Pediatr Orthop. 2015;35(4):334–40.
Liu TJ, Wang EB, Dai Q, Zhang LJ, Li QW, Zhao Q. Open reduction and internal fixation for the treatment of fractures of the lateral humeral condyle with an early delayed presentation in children: a radiological and clinical prospective study. Bone Joint J. 2016;98-B(2):244–8.
Jakob R, Fowles JV, Rang M, Kassab MT. Observations concerning fractures of the lateral humeral condyle in children. J Bone Joint Surg Br. 1975;57(4):430–6.
Song KS, Kang CH, Min BW, Bae KC, Cho CH, Lee JH. Closed reduction and internal fixation of displaced unstable lateral condylar fractures of the humerus in children. J Bone Joint Surg Am. 2008;90(12):2673–81.
Badelon O, Bensahel H, Mazda K, Vie P. Lateral humeral condylar fractures in children: a report of 47 cases. J Pediatr Orthop. 1988;8(1):31–4.
Hasler CC, von Laer L. Prevention of growth disturbances after fractures of the lateral humeral condyle in children. J Pediatr Orthop B. 2001;10(2):123–30.
Pribaz JR, Bernthal NM, Wong TC, Silva M. Lateral spurring (overgrowth) after pediatric lateral condyle fractures. J Pediatr Orthop. 2012;32(5):456–60.
Davids JR, Maguire MF, Mubarak SJ, Wenger DR. Lateral condylar fracture of the humerus following posttraumatic cubitus varus. J Pediatr Orthop. 1994;14(4):466–70.
Kim DS, Hwang SH, Kwon CS, Ahn JK, Jung BH, Sung YB, et al. Results of Treatment of Fracture-Dislocations of Elbow. Journal of the Korean Society of Fractures. 2000;13(1).
Bast SC, Hoffer MM, Aval S. Nonoperative treatment for minimally and nondisplaced lateral humeral condyle fractures in children. J Pediatr Orthop. 1998;18(4):448–50.
Conner AN SM. Displaced fractures of the lateral humeral condyle in children. J Bone Joint Surg Br. 1970;52:460–464.
VII CF. Elbow fractures in children. Fractures of the lower end of the humerus. Ann Surg. 1902;35:75–104.
Launay F, Leet AI, Jacopin S, Jouve JL, Bollini G, Sponseller PD. Lateral humeral condyle fractures in children: a comparison of two approaches to treatment. J Pediatr Orthop. 2004;24(4):385–91.
Thomas DP, Howard AW, Cole WG, Hedden DM. Three Weeks of Kirschner Wire Fixation for Displaced Lateral Condylar Fractures of the Humerus in Children. Journal of Pediatric Orthopaedics. 2001;21(5):565–9.
Naik P. Remodelling in Children's Fractures and Limits of Acceptability. Indian J Orthop. 2021;55(3):549–59.
Shapiro F. Fractures of the femoral shaft in children. The overgrowth phenomenon. Acta Orthop Scand. 1981;52(6):649–55.
H Emneus OH. Overgrowth following fracture of humerus in children. Acta Orthop Scand. 1964;35:51–8.
Malkawi H, Shannak A, Hadidi S. Remodeling after femoral shaft fractures in children treated by the modified blount method. J Pediatr Orthop. 1986;6(4):421–9.

No competing interests reported.

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Age affects lateral spurring after pediatric humerus lateral condyle fractures: A retrospective cohort study Authorship

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Version 1

Abstract

Figures

Introduction

METHODS

Patient selection

Parameter selection

Treatment method

Statistical analysis

RESULTS

Clinical characteristics

Relationship between age and lateral spurring

DISCUSSION

Declarations

References

Additional Declarations

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