The unignorable N protein of COVID-19
With more and more people infected with COVID-19, it was found that the SARS-CoV-2 virus was quite different from SARS-CoV. Most researches have focused on ACE2 and S protein, however, the known variations of these proteins are not enough to explain why there were so many different clinical manifestations between patients infected with such two viruses. Here, the N protein of the two coronaviruses was parallelly analyzed. Through the analysis of N protein structure, protein conserved binding domain, binding site and ligand, and CTL epitope, it was found that N protein may have a unique expression profile in the SARS-CoV-2. For example, mirror structure and RNA binding tendency.
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Posted 09 Jun, 2020
The unignorable N protein of COVID-19
Posted 09 Jun, 2020
With more and more people infected with COVID-19, it was found that the SARS-CoV-2 virus was quite different from SARS-CoV. Most researches have focused on ACE2 and S protein, however, the known variations of these proteins are not enough to explain why there were so many different clinical manifestations between patients infected with such two viruses. Here, the N protein of the two coronaviruses was parallelly analyzed. Through the analysis of N protein structure, protein conserved binding domain, binding site and ligand, and CTL epitope, it was found that N protein may have a unique expression profile in the SARS-CoV-2. For example, mirror structure and RNA binding tendency.
Figure 1
Figure 2
Figure 3
Figure 4
Figure 5