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Predictors of thyroglobulin in the lymph nodes recurrence of papillary thyroid carcinoma undergoing total thyroidectomy
Anping Su
Sichuan University West China Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2289-9339
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Surgery.
Background: To investigate the association between postoperative lymph nodes (LNs) recurrence and distinct serum thyroglobulin (Tg) levels in patients with papillary thyroid carcinoma (PTC).
Methods: This study included PTC patients who underwent total thyroidectomy (TT) with at least central neck dissection and then re-operated due to recurrence of LNs between January 2013 and June 2018. These patients were grouped by negative or positive serum Tg levels according to the American Thyroid Association guidelines.
Results: Of the 60 included patients, 49 underwent radioactive iodine (RAI) treatment. Maximum unstimulated Tg (uTg) ≥ 0.2 ng/mL were associated with larger diameter of recurrent LNs (P = 0.027), and higher rate of metastatic LNs (P < 0.001). Serum-stimulated Tg (off-Tg) ≥ 1ng/mL (P = 0.047) and unstimulated Tg (on-Tg) ≥ 0.2 ng/Ml (P = 0.013) were associated with larger diameter of recurrent LNs. Number of metastatic LNs ≥ 8 was an independent predictor for postoperative maximum uTg ≥ 0.2 ng/mL (OR = 8.767; 95% CI =1.392-55.216; P = 0.021). Ratio of metastatic LNs ≥ 25% was an independent predictor for off-Tg ≥ 1 ng/mL (OR = 20.997; 95% CI =1.649-267.384; P = 0.019).
Conclusion: Postoperative Tg-positive status was associated with larger size of recurrent LNs. Number of metastatic LNs ≥8 and ratio of metastatic LNs ≥ 25% were independent predicators for uTg-positive and off-Tg-positive status, respectively.
Keywords
thyroglobulin, lymph nodes recurrence, papillary thyroid carcinoma, radioactive iodine treatment
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Editorial decision: Minor revision
On 10 Jan, 2021
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Received 09 Jan, 2021
Review #2 received
Received 05 Jan, 2021
Reviewer #2 agreed
On 03 Jan, 2021
Reviewer #1 agreed
On 02 Jan, 2021
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On 29 Dec, 2020
Reviewers invited
Invitations sent on 29 Dec, 2020
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On 29 Dec, 2020
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Review #2 received
Received 30 Nov, 2020
Editorial decision: Major revision
On 30 Nov, 2020
Reviewer #2 agreed
On 12 Nov, 2020
Review #1 received
Received 31 Oct, 2020
Reviewer #1 agreed
On 25 Oct, 2020
Editor assigned
On 12 Oct, 2020
Reviewers invited
Invitations sent on 12 Oct, 2020
Submission checks complete
On 11 Oct, 2020
Editor invited
On 11 Oct, 2020
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Editorial decision: Minor revision
On 23 Sep, 2020
Review #2 received
Received 22 Sep, 2020
Review #1 received
Received 08 Sep, 2020
Reviewer #2 agreed
On 03 Sep, 2020
Reviewer #1 agreed
On 02 Sep, 2020
Reviewers invited
Invitations sent on 08 Jul, 2020
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Editor assigned
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Editor invited
On 09 Jun, 2020
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This preprint is under consideration at BMC Surgery. A preprint is a preliminary version of a manuscript that has not completed peer review at a journal. Research Square does not conduct peer review prior to posting preprints. The posting of a preprint on this server should not be interpreted as an endorsement of its validity or suitability for dissemination as established information or for guiding clinical practice.
Learn more about In Review
Research article
Predictors of thyroglobulin in the lymph nodes recurrence of papillary thyroid carcinoma undergoing total thyroidectomy
Anping Su
Sichuan University West China Hospital
Corresponding Author
ORCiD: https://orcid.org/0000-0003-2289-9339
Badges
Prescreen
This manuscript passed our Prescreen assessment
Complete author information
Appropriate declaration statements
Potential risks to human health
Prescreen
Peer Review Timeline
CURRENT STATUS: Published
Version 4
Posted 22 Jan, 2021
Published
On 22 Jan, 2021
No community comments so far
Submission checks complete
On 18 Jan, 2021
Editorial decision: Accept
On 13 Jan, 2021
No comments provided
Editorial decision: Minor revision
On 10 Jan, 2021
Review #1 received
Received 09 Jan, 2021
Review #2 received
Received 05 Jan, 2021
Reviewer #2 agreed
On 03 Jan, 2021
Reviewer #1 agreed
On 02 Jan, 2021
Editor assigned
On 29 Dec, 2020
Reviewers invited
Invitations sent on 29 Dec, 2020
Submission checks complete
On 29 Dec, 2020
Editor invited
On 29 Dec, 2020
No comments provided
Review #2 received
Received 30 Nov, 2020
Editorial decision: Major revision
On 30 Nov, 2020
Reviewer #2 agreed
On 12 Nov, 2020
Review #1 received
Received 31 Oct, 2020
Reviewer #1 agreed
On 25 Oct, 2020
Editor assigned
On 12 Oct, 2020
Reviewers invited
Invitations sent on 12 Oct, 2020
Submission checks complete
On 11 Oct, 2020
Editor invited
On 11 Oct, 2020
No comments provided
Editorial decision: Minor revision
On 23 Sep, 2020
Review #2 received
Received 22 Sep, 2020
Review #1 received
Received 08 Sep, 2020
Reviewer #2 agreed
On 03 Sep, 2020
Reviewer #1 agreed
On 02 Sep, 2020
Reviewers invited
Invitations sent on 08 Jul, 2020
First submitted
On 10 Jun, 2020
Editor assigned
On 10 Jun, 2020
Submission checks complete
On 09 Jun, 2020
Editor invited
On 09 Jun, 2020
Metrics
Comments: 0
PDF Downloads: ...
HTML Views: ...
License:
This work is licensed under a CC BY 4.0 License. Read Full License
View the published version at BMC Surgery.
Background: To investigate the association between postoperative lymph nodes (LNs) recurrence and distinct serum thyroglobulin (Tg) levels in patients with papillary thyroid carcinoma (PTC).
Methods: This study included PTC patients who underwent total thyroidectomy (TT) with at least central neck dissection and then re-operated due to recurrence of LNs between January 2013 and June 2018. These patients were grouped by negative or positive serum Tg levels according to the American Thyroid Association guidelines.
Results: Of the 60 included patients, 49 underwent radioactive iodine (RAI) treatment. Maximum unstimulated Tg (uTg) ≥ 0.2 ng/mL were associated with larger diameter of recurrent LNs (P = 0.027), and higher rate of metastatic LNs (P < 0.001). Serum-stimulated Tg (off-Tg) ≥ 1ng/mL (P = 0.047) and unstimulated Tg (on-Tg) ≥ 0.2 ng/Ml (P = 0.013) were associated with larger diameter of recurrent LNs. Number of metastatic LNs ≥ 8 was an independent predictor for postoperative maximum uTg ≥ 0.2 ng/mL (OR = 8.767; 95% CI =1.392-55.216; P = 0.021). Ratio of metastatic LNs ≥ 25% was an independent predictor for off-Tg ≥ 1 ng/mL (OR = 20.997; 95% CI =1.649-267.384; P = 0.019).
Conclusion: Postoperative Tg-positive status was associated with larger size of recurrent LNs. Number of metastatic LNs ≥8 and ratio of metastatic LNs ≥ 25% were independent predicators for uTg-positive and off-Tg-positive status, respectively.
Figure 1